Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,856 recruiting studies in this area right now.
By phase
- Not applicable2,770
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,856 total
- NCT07199127Recruiting
Studying duodenal polyps in FAP
This study reviews duodenal polyps in people with FAP to improve how they are classified. It uses existing medical records from endoscopies (scope tests) to help doctors better understand and manage polyp growth.
Milan, MIAges 18 years+ - NCT07201025Recruiting
MRI study of kidney disease in ARPKD
This study uses MRI scans to track kidney disease progression in children and adults with ARPKD. It aims to better understand how the disease changes over time, which could help improve future care.
Cleveland, OhioAges 6 years+ - NCT07201012Recruiting
Finding skin tumors in Lynch syndrome patients
This study looks for Muir-Torre syndrome, a condition that causes certain skin tumors, in people who already have Lynch syndrome. It may help doctors understand how common this skin condition is in Lynch syndrome patients.
Nîmes, GardAges Any age - NCT07202910Recruiting
Validating liver imaging in children
This study tests if non-invasive imaging (like ultrasound) can replace liver biopsies in children with liver disease. It may help avoid the need for a needle biopsy in the future.
Gothenburg, Västra Götaland CountyAges Up to 25 years - NCT07203469Recruiting
Nature and activity groups for neurodivergent children
This trial explores whether group activities in nature can help neurodivergent children and youth feel better. It is part of a PhD project, with different phases for different groups.
Kristiansand, AgderAges 5–18 - NCT07204561Recruiting
CeraVe cream for keeping skin hydrated after atopic dermatitis treatment
This trial tests whether using CeraVe moisturizer can keep your skin hydrated and prevent flare-ups after your eczema has been cleared with a steroid treatment. It is for adults with mild to moderate eczema that gets better with steroids.
Roma, RMAges 18–99 - NCT07205523Recruiting
High-altitude blood study for stem cell transplant patients
This study observes how blood and stem cell transplants work for patients with blood diseases at high altitude. It aims to learn more to help future patients.
Xining, QinghaiAges Any age - NCT07206095Recruiting
Better diagnosis for inherited red blood cell diseases
This trial aims to improve how doctors diagnose rare inherited anemias, including sickle cell disease and other conditions that destroy red blood cells. It may help if you have a confirmed or suspected diagnosis but need more clarity through advanced testing.
Barcelona, BarcelonaAges Any age - NCT07209462RecruitingPhase 2
MRM-3379 for Fragile X Syndrome in males
This trial tests an investigational medicine called MRM-3379 in males with Fragile X syndrome. It looks at how the medicine affects thinking and behavior over time.
Phoenix, ArizonaAges 13–45 - NCT07210775RecruitingPhase 1/Phase 2
Imiquimod cream for mouth precancer
This trial tests a cream called imiquimod for people who have been diagnosed with oral dysplasia, a precancerous condition in the mouth. It is an option for those who cannot or choose not to have surgery or laser treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT07211776RecruitingPhase 3
Study of ZL-1109 for active thyroid eye disease
This trial tests a new drug called ZL-1109 for people with active, moderate to severe thyroid eye disease (TED). It aims to see if the drug can reduce symptoms like bulging eyes and help patients feel better without using steroids.
BeijingAges 18–75 - NCT07213063Recruiting
Creatine and HMB supplements for Down syndrome
This trial tests whether taking creatine and HMB supplements can improve muscle strength, reduce inflammation, and increase muscle mass in people with Down syndrome. It may help if you or your loved one can do basic physical tests like standing from a chair and do not have kidney disease or severe mobility issues.
Burgos, BurgosAges 18 years+ - NCT07213297Recruiting
Program for hereditary transthyretin amyloidosis
This trial is for people with a specific inherited form of amyloidosis caused by a change in the TTR gene. It offers a comprehensive care program to help manage this rare condition.
Canuelas, Buenos AiresAges 18 years+ - NCT07215416RecruitingPhase 1/Phase 2
Gene therapy for ataxia-telangiectasia with specific ATM mutation
This trial tests a new genetic medicine designed for people with A-T who have a specific ATM gene change. It aims to see if the treatment is safe and if it can improve symptoms.
Boston, MassachusettsAges birth–17 years - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT07216664Recruiting
Early mouth care with human milk for very preterm babies
This study tests whether giving tiny amounts of human milk to the mouth early can help very preterm babies (born at 32 weeks or earlier) learn to feed better. It may reduce the time they need IV fluids or a feeding tube.
Maywood, IllinoisAges 5 months–7 months - NCT07219537Recruiting
Imaging the lower gut with a new capsule
This trial tests a new type of camera capsule that takes pictures of the lower part of your digestive tract. It may be an option for people who are healthy or have Lynch Syndrome and have had a recent normal colonoscopy.
Boston, MassachusettsAges 18–75 - NCT07220239Recruiting
Menstrual cup for early cancer detection in Lynch syndrome
This study tests whether a menstrual cup can collect cells from the uterus to detect early endometrial cancer in women with Lynch syndrome. If you have Lynch syndrome and are due for a routine biopsy, you may be able to use a menstrual cup instead.
Boston, MassachusettsAges 18 years+ - NCT07220603RecruitingPhase 2
Long-term safety study for people with myotonic dystrophy type 1
This is a follow-up study for people with myotonic dystrophy type 1 who already received the study drug PGN-EDODM1 in an earlier trial. It lets you continue treatment and helps researchers learn more about long-term safety and effects.
Calgary, AlbertaAges Any age - NCT07220564RecruitingPhase 1
Testing an oral medication for hemophilia A
This study tests an experimental oral medication (Inno8) for people with hemophilia A. It aims to find the best dose and see how the body handles it. You may be able to join if you have mild to severe hemophilia A and are not on other preventive treatments.
Aurora, ColoradoAges 18–64 - NCT07221331Recruiting
Neurofibromatosis type 1 study in Egypt
This study looks at how neurofibromatosis type 1 (NF1) affects people in Egypt, including how it progresses and how it is managed. Researchers will review medical records of patients diagnosed with NF1 between 2010 and 2023 to learn more about the condition.
Al MansurahAges Any age - NCT07222475Recruiting
Songwriting for relaxation in sickle cell teens
This trial explores whether writing calming songs can help teenagers with sickle cell disease feel more relaxed. Teens ages 11-18 who get care at a pediatric center can join.
Rochester, MinnesotaAges 11–18 - NCT07223944RecruitingPhase 3
Gene therapy trial for Gaucher disease type 1
This trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. It aims to provide a long-term treatment option for people who have been stable on enzyme replacement therapy (ERT) or substrate reduction therapy (SRT) for at least two years.
Los Angeles, CaliforniaAges 18 years+ - NCT07224308Recruiting
Long-term effects of MFU-V on sagging skin
This study tests a non-invasive ultrasound treatment called MFU-V for sagging skin, fine lines, and crepey skin on the lower face, under the chin, and neck. It aims to see how long the results last and how well different treatment depths work.
New York, New YorkAges 25–65
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,856 recruiting medical genetics studies from the U.S. registry right now, out of 5,791 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.