Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,767 recruiting studies in this area right now.
By phase
- Not applicable2,684
- Phase 2280
- Phase 1241
- Phase 3210
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease134
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)38
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts108
- Arizona87
- New York85
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,767 total
- NCT06043440RecruitingPhase 2
Oxygen therapy for sleep apnea in Down syndrome
This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.
Los Angeles, CaliforniaAges 5–18 - NCT06035939Recruiting
SCD support study using mobile app
This trial tests a mobile app to help people with sickle cell disease manage their health. It's designed for those who have a compatible smartphone and internet access.
Charleston, South CarolinaAges 14–21 - NCT06034405Recruiting
Checking spine tissue for heart amyloidosis signs
This trial is looking at leftover tissue from past spine surgeries to see if it contains signs of a heart condition called TTR amyloidosis. It may help find people who have this condition early.
Beverly Hills, CaliforniaAges 50 years+ - NCT06041685Recruiting
Warming for artery catheter in children under 2
This trial tests if warming the skin before placing an artery line helps children having heart surgery. It may make the procedure easier and more comfortable.
Yangsan, Gyeongsangnam-doAges Up to 2 years - NCT06048510Recruiting
New blood markers to predict pregnancy diabetes and large babies
This study tests if new blood markers can help predict gestational diabetes and the risk of having a large baby. It could lead to earlier detection and better care.
BordeauxAges 18–99 - NCT06045702Recruiting
Study of CFTR gene in epididymal cells from surgery
This study collects a small tissue sample from the epididymis during planned surgery. The sample is used to study how the CFTR gene works, which may help understand fertility problems in men with cystic fibrosis.
BrestAges 18 years+ - NCT06041906Enrolling by invitation
International registry for congenital portosystemic shunt
This registry is gathering information from people who have a rare liver blood vessel problem they were born with (congenital portosystemic shunt). By joining, you help researchers learn more about this condition and improve future care.
New Haven, ConnecticutAges 1 day+ - NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75 - NCT06054230Enrolling by invitation
Genetic sequencing for fetal structural problems
This study offers genetic sequencing to find the cause of certain serious fetal problems, such as structural anomalies, severe growth restriction, or unexplained pregnancy loss after 14 weeks. It aims to help families understand why the issue occurred and guide future care.
San Francisco, CaliforniaAges 18–64 - NCT06034392Enrolling by invitation
CHAMP app study for kids with complex heart conditions
This study tests whether using a mobile app to monitor children with complex health conditions at home can help their care team. Families will use the app to share health information instead of only in clinic visits.
Washington D.C., District of ColumbiaAges Up to 18 years - NCT06041334Recruiting
Spina Bifida blood vessel study
This trial studies blood vessels in people with spina bifida using safe, non-invasive methods. It aims to better understand how the condition affects the body over time.
Rennes, CHU de RennesAges 6 years+ - NCT06040242Recruiting
Exercise and heart rhythm study for ARVC patients
This study looks at how exercise affects heart rhythm in people with ARVC, a genetic heart condition. Participation involves supervised exercise sessions and heart monitoring to better understand safe activity levels.
Zurich, Canton of ZurichAges 14 years+ - NCT04129021Recruiting
Eye imaging test with fast detailed scans
This trial studies whether a new, very high-resolution and high-speed eye scan can be used for people with eye problems or for healthy volunteers. It may help doctors better “see” eye structures more clearly to guide care.
ParisAges 18 years+ - NCT04713657RecruitingPhase 1
Beta-blocker study for heart muscle function in young babies
This trial tests whether a beta-blocker called propranolol can improve how well heart muscle cells work in very young babies with certain congenital heart conditions. It mainly looks at safety and how the medicine affects the heart, which could help guide future treatments.
New York, New YorkAges 4 weeks–2 months - NCT05989620Recruiting
Long-term study of muscular dystrophy functions
This study tracks changes in muscle strength and breathing over time in people with certain types of muscular dystrophy. It helps researchers develop better tests to measure how the disease progresses.
Richmond, VirginiaAges 6–50 - NCT06019182Recruiting
MEHMO syndrome: Understanding the condition over time
This study follows people with or at risk for MEHMO syndrome over time to better understand the condition and identify biological markers. It may include both affected individuals and their family members to see how the condition runs in families.
Bethesda, MarylandAges 1 week–100 years - NCT06016634RecruitingPhase 2
Alendronate for bone damage in adults with sickle cell disease
This trial tests if the drug alendronate can help heal bone damage caused by sickle cell disease. It may be an option if you have this bone problem and are between 18 and 80 years old.
Sacramento, CaliforniaAges 18–80 - NCT06018519Recruiting
Measuring outcomes for creatine transporter deficiency
This study aims to find the best ways to measure how creatine transporter deficiency (CTD) affects people. It includes both males and females with CTD, as well as healthy volunteers, to compare results and develop better tests.
BronAges 2–60 - NCT06005181Recruiting
Music training for children with FASD
This study tests whether music training can help children with Fetal Alcohol Spectrum Disorder (FASD). It aims to see if learning music improves brain function and behavior.
Albuquerque, New MexicoAges 8–16 - NCT06003023Recruiting
Physical activity study for teens with congenital heart disease
This study looks at how teens and young adults with moderate to complex congenital heart disease can improve their physical activity. You might be eligible if you're between 15 and 25, have a heart condition, and get care at Nationwide Children's Hospital or Ohio State University.
Columbus, OhioAges 15–25 - NCT06015191Recruiting
Remote heart rehab for teens with congenital heart disease
This trial tests a home-based cardiac rehab program for adolescents with certain types of congenital heart disease. It aims to help you exercise safely and improve your fitness using online coaching and monitoring.
Kansas City, MissouriAges 12–19 - NCT06025734Recruiting
Nerve stimulation for bladder control in spina bifida
This study tests whether stimulating a nerve in the leg (the tibial nerve) with a small device can help children with spina bifida who leak urine even when using a catheter. The treatment is non-invasive, like a tiny electrical patch near the ankle, and aims to improve bladder control.
Dallas, TexasAges 8–18 - NCT06016946Recruiting
Friedreich's Ataxia Natural History Study
This study follows people with Friedreich's ataxia (FA) over time to learn more about the disease. It helps researchers understand how FA affects people of all ages and may lead to better treatments.
Los Angeles, CaliforniaAges Any age - NCT06008938Recruiting
Study tracking HEMGENIX for hemophilia B
This study watches how well HEMGENIX works and how safe it is for people with hemophilia B who are getting the treatment. It also compares data from adults on standard factor IX shots.
Rochester, New YorkAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,767 recruiting medical genetics studies from the U.S. registry right now, out of 5,497 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.