Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07557446RecruitingPhase 2
Testing AGA2115 for Osteogenesis Imperfecta in Chinese Patients
This study tests a new medicine called AGA2115 in adults and teenagers with osteogenesis imperfecta (brittle bone disease). The trial aims to find the right dose and see if it can strengthen bones and reduce fracture risk.
Beijing, Beijing MunicipalityAges 12–75 - NCT07559253Recruiting
Heart Care Transition Education Led by Nurses or Doctors
This study tests whether nurse-led or doctor-led education helps young people with congenital heart disease (a heart condition present from birth) transition from pediatric to adult care. The goal is to make this transition smoother and more accessible for all patients, including those with disabilities.
Madison, WisconsinAges 12–26 - NCT07559864RecruitingPhase 2
Regorafenib plus Envafolimab for treatment-resistant gastrointestinal stromal tumors
This study tests a combination of two drugs (regorafenib and envafolimab) for gastrointestinal stromal tumors (a type of stomach/bowel cancer) that have stopped responding to standard treatments. The trial compares this combination to other doctor-selected treatments to see if it slows tumor growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07559942Recruiting
Apiban to Help Dialysis Fistulas Mature Successfully
This trial tests whether a blood-thinner medication called apixaban (Apiban) helps arteriovenous fistulas—surgically created connections in the arm for dialysis—develop and work better. If it helps fistulas mature faster and more reliably, it could reduce complications and improve treatment for kidney failure patients.
Lahore, Punjab ProvinceAges 18 years+ - NCT07561697Recruiting
Achilles Tendon Surgery Options for Clubfoot in Young Children
This study compares two surgical approaches to lengthen the Achilles tendon (the cord at the back of the heel) in young children with clubfoot—a condition where the foot is twisted inward and downward. The goal is to find which method works better and causes fewer complications.
Karachi, SindhAges 2–5 - NCT07561957Recruiting
Smartphone app to help manage chronic kidney disease
This study tests a smartphone app designed to help people with chronic kidney disease (CKD)—a condition where the kidneys don't filter blood as well as they should—follow the latest medical guidelines. The app aims to make it easier for younger adults to stay on top of their kidney health and treatment.
DublinAges 16–30 - NCT07563218Recruiting
Online skill-building program for teens and young adults with genetic conditions
This trial tests I-TOPS, an online program designed to help teenagers and young adults with genetic syndromes build practical life skills. You and a parent or caregiver would participate together from home using a computer and internet connection.
Bosisio Parini, LeccoAges 11–39 - NCT07563660Recruiting
Heart imaging study for arrhythmogenic right ventricular cardiomyopathy
This study uses a special type of heart scan (FAPI PET/CT) to better visualize and understand arrhythmogenic right ventricular cardiomyopathy (ARVC), a condition where the heart muscle weakens and causes irregular heartbeats. The scan may help doctors understand the disease better and improve patient care.
Istanbul, FatihAges 18 years+ - NCT07565636Recruiting
Custom 3D-Printed Wrist Support for Ehlers-Danlos Syndrome
This trial tests a custom-made wrist brace designed with 3D printing technology to help stabilize loose, overly flexible wrists in people with Ehlers-Danlos syndrome. The goal is to see if this personalized support can improve wrist function and reduce pain or instability.
Lowell, MassachusettsAges 21 years+ - NCT07567131Recruiting
Understanding sun sensitivity in rare porphyria disorders
This study tracks how your body reacts to sunlight if you have erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP)—rare genetic conditions that cause painful skin reactions to sun exposure. Researchers will use special devices and daily logs to better understand your symptoms and how light affects your skin.
Boston, MassachusettsAges 12 years+ - NCT07569419RecruitingEarly Phase 1
Testing Linaclotide for Cystic Fibrosis Bowel Function
This early-stage study tests whether a medication called linaclotide can help improve bowel function in people with cystic fibrosis. Researchers will use MRI scans and other tests to see how the medication affects your digestive system.
NottinghamAges 18–65 - NCT07569445Recruiting
Brain activity and hearing tests in Rett syndrome
This study measures brain waves and hearing in people with Rett syndrome to better understand how the condition affects the brain's ability to process sound. The information may help develop better treatments and support.
Rochester, New YorkAges 2 years+ - NCT07569835Recruiting
Long-Term Outcomes of Childhood Flatfoot Surgery
This study follows up with patients who had surgery to correct flat feet in childhood using special implants. Researchers want to see how well the surgery worked over 10 years and whether any changes occurred in the foot structure.
BolognaAges Any age - NCT07570121RecruitingPhase 1
How Caffeine Moves Through Pregnancy and to the Baby
This study looks at how caffeine is absorbed and transferred to a baby during pregnancy in women at risk of early delivery. Researchers hope to understand safe caffeine use in this situation and potentially help prevent complications.
Indianapolis, IndianaAges 18 years+ - NCT07570459Recruiting
Understanding Tremor in Charcot-Marie-Tooth Disease
This study examines tremor (involuntary shaking) in people with Charcot-Marie-Tooth disease, a genetic nerve condition that affects the legs and feet. Researchers will compare people with CMT who have tremor to healthy volunteers to better understand this symptom.
Göttingen, Lower SaxonyAges 18–65 - NCT07570446Recruiting
Autonomic Function in Charcot-Marie-Tooth Disease
This study examines how autonomic nerves (the nerves that control automatic body functions like heart rate and blood pressure) are affected in people with CMT (Charcot-Marie-Tooth disease), a genetic nerve disorder. Understanding this may help improve treatment and quality of life for CMT patients.
Göttingen, Lower SaxonyAges 18–65 - NCT07572825RecruitingPhase 1
Safety study of NMN supplement for DHDDS-CDG
This trial tests whether a supplement called NMN is safe and well-tolerated in children and adults with a rare genetic condition called DHDDS-CDG. NMN may help support cellular energy and protein production, which are affected by this condition.
New York, New YorkAges 4 years+ - NCT07573059Recruiting
Safety study of a test system for Loargys-treated patients
This study evaluates whether a new test system is safe to use in patients who are already taking Loargys (a medicine for a rare condition called ARG1-D, which affects how the body processes a protein building block called arginine). The study simply observes how the test system works in people already on this treatment.
Atlanta, GeorgiaAges birth–100 years - NCT07573735Recruiting
Blood markers and skin inflammation in atopic dermatitis
This study examines a specific blood marker (cfDNA-STING) that may help explain why atopic dermatitis develops. Researchers will compare this marker in people with and without atopic dermatitis to understand the condition better.
Nanjing, JiangsuAges 18 years+ - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT07576504Recruiting
Physical therapy technique for flat feet in children
This study tests whether a special movement-based technique can help reduce flat feet in school-age children. Flat feet can affect how kids walk and play, and this therapy may help improve foot arch height.
Lahore, Punjab ProvinceAges 7–12 - NCT07576816Recruiting
Hip vs. Knee Exercises for Flat Feet
This study compares two types of exercises—one focusing on hip muscles and one on knee muscles—to see which better improves flat feet, balance, and leg strength. If you have flexible flat feet without pain, this trial may help you strengthen your feet and improve stability.
Faisalābad, Punjab ProvinceAges 25–40 - NCT07578922Recruiting
Bean Bag Game for Balance and Walking in Children With Down Syndrome
This study tests whether playing a bean bag tossing game helps children with Down syndrome improve their balance and walking ability. The game is designed to be fun while building strength and coordination.
Lahore, Punjab ProvinceAges 5–17 - NCT07578974Recruiting
Foot-Strengthening Training for Children with Flat Feet
This study tests whether special exercises that strengthen the small muscles in your child's foot—with or without visual feedback on a screen—can improve flat feet and balance in children ages 7–12. Flat feet are common in kids and usually improve on their own, but this trial explores whether targeted training helps.
Lahore, Punjab ProvinceAges 7–12
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.