Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07029282RecruitingPhase 3
Vitamin supplement study for pregnant women and new moms
This trial tests a special vitamin supplement (MMSPlus) given before and after birth to improve baby growth. Pregnant women with a healthy single baby can join, and then continue after birth if they plan to breastfeed.
Karachi, SindhAges 15–49 - NCT07029984Recruiting
Testing a bowel control scale for anorectal malformation
This study tests if a scale called the Baylor Continence Scale works well for children who had surgery for anorectal malformation. It helps measure bowel control, which can guide better care.
IzmirAges 6–18 - NCT06722534Recruiting
Celecoxib to prevent polyps from growing in Peutz-Jeghers Syndrome
This trial is testing if the medication celecoxib can stop or slow the growth of polyps in people with Peutz-Jeghers Syndrome (PJS). It may help reduce the need for surgery and lower the risk of complications.
Xi'an, ShaanxiAges 8 years+ - NCT06490627RecruitingPhase 2
thalidomide for transfusion-dependent beta thalassemia
This trial tests different doses of thalidomide to see if it can reduce or eliminate the need for blood transfusions in people with beta thalassemia major or intermedia.
Karachi, SindhAges 8–35 - NCT07015203Recruiting
First trimester combined screening study
This study offers a combined screening test for pregnant women in their first trimester. It helps check for potential health issues early in pregnancy.
Most, CzechiaAges 18 years+ - NCT07014007Recruiting
Testing a new moisturizer for eczema in different age groups
This study tests a new moisturizing product (RV4421B) for people with mild to moderate atopic dermatitis (eczema). Participants will use the product along with their usual steroid cream for 12 weeks to see how well it works and if it’s safe for different ages, from babies to adults.
Quatre Bornes, MauritiusAges 3 months+ - NCT07016750RecruitingPhase 3
Study of KB803 eye drops for eye scrapes in DEB
This study tests an experimental eye drop (KB803) to see if it can reduce painful scrapes on the surface of the eye in people with dystrophic epidermolysis bullosa. You would be randomly assigned to receive either the study drops or a placebo (an inactive drop) for several months.
Rancho Santa Margarita, CaliforniaAges 6 months+ - NCT07023666RecruitingPhase 2
Early heart screening and treatment for sickle cell disease
This trial tests early screening and treatment to prevent heart problems in people with sickle cell disease. It focuses on those with high iron levels or heart symptoms, using regular heart imaging to monitor and treat complications early.
Fairfax, VirginiaAges 18 years+ - NCT07016009Recruiting
Thrive program for young adults with fetal alcohol spectrum disorders
This trial tests a person-centered planning program called Thrive for young adults aged 18–25 with fetal alcohol spectrum disorders (FASD). The program aims to help them set goals and build skills using video calls.
Rochester, New YorkAges 18–25 - NCT07015632Recruiting
Fall risk screening with sensors in Duchenne MD
This study uses a machine-learning tool (like a smart computer program) to help predict fall risk in people with Duchenne Muscular Dystrophy. It involves wearing sensors to track your movement and balance, which could help doctors create safer care plans.
Seoul, JongnoAges 10–30 - NCT07019558Recruiting
Eye disorders in dominant spinal-cerebellar ataxias
This trial looks for eye problems in people with certain genetic forms of spinocerebellar ataxia (SCA1, SCA2, SCA3, or SCA27B). You have to be between 18 and 80 years old and have a specific genetic mutation. You can join if you already have symptoms or if you are at risk but do not have symptoms yet.
Montpellier, HéraultAges 18–80 - NCT07019857Recruiting
Thymus removal and immunity in infant heart surgery
This study looks at how removing the thymus gland during infant heart surgery affects the immune system. It compares babies who have their thymus removed with those who have heart surgery without removing it, and with babies having other types of surgery.
NantesAges Up to 6 months - NCT07015684RecruitingPhase 1
Radioactive antibody and transplant for advanced sickle cell disease
This trial tests a radioactive antibody (131I-apamistamab) as part of conditioning before a stem cell transplant from a matched sibling donor. It aims to make the transplant safer and more effective for people with severe sickle cell disease.
New York, New YorkAges 12–50 - NCT07015762RecruitingPhase 1
Testing IBI3002 for moderate-to-severe eczema
This trial tests a new drug called IBI3002 in people with moderate-to-severe atopic dermatitis (eczema) to see if it is safe and tolerable. It may help reduce skin inflammation and itching.
Suzhou, JiangsuAges 18–65 - NCT07017842Recruiting
Predicting outcomes for hypospadias surgery
This study follows boys having their first surgery for hypospadias (where the pee hole is not at the tip of the penis) to find out what factors lead to the best results. The goal is to help doctors better predict who will have a smooth recovery.
Doha, Baladiyat ad DawhahAges 1–12 - NCT07023367Recruiting
Parent navigator program for Latino families of babies with heart disease
This study offers a parent navigator program to help Latino families whose baby had early heart surgery. The program aims to support both the child's recovery and the parents' well-being.
Los Angeles, CaliforniaAges birth+ - NCT07021495Recruiting
Skin disease study to improve treatment choices
This study looks at different skin diseases to find markers that can help guide treatment. It tests new treatments for several conditions like eczema, psoriasis, and lupus, with the goal of personalizing care.
Nijmegen, GelderlandAges 18 years+ - NCT07018765Recruiting
Mindfulness program for birth memory and trauma
This study tests if an 8-week online mindfulness program (MBSR) can help women who had a vaginal birth feel better about their birth memory and reduce feelings of trauma. You would join online group sessions from home.
Malatya, Leave BlankAges 18–45 - NCT07015073Recruiting
Comparing laser combinations for port-wine stains
This trial tests whether using two different lasers one after the other works better than a single laser for treating port-wine stains (a type of birthmark). The goal is to see if the combination treatment can improve appearance with fewer sessions.
Madrid, SpainAges 18 years+ - NCT05225311Recruiting
Registry for pregnancies with Ebstein and tricuspid valve issues
This registry collects information about pregnancies where the baby is diagnosed with Ebstein anomaly and/or tricuspid valve dysplasia. It helps doctors learn how these heart conditions affect pregnancies and outcomes, and can support better future care.
Toronto, OntarioAges Any age - NCT07006649Recruiting
Study of blood flow in the eye for pseudoxanthoma elasticum
This study looks at blood flow in a layer of the eye called the choriocapillaris in people with pseudoxanthoma elasticum (PXE). It compares these findings with healthy volunteers to understand eye changes before they become severe.
AngersAges 18 years+ - NCT07003425RecruitingPhase 2
Long-term safety and effectiveness of APG777 for eczema
This study looks at the long-term safety and how well APG777 works for people with eczema (atopic dermatitis). It is for people who have already completed treatment with APG777 in an earlier study and may benefit from continuing it.
Fountain Valley, CaliforniaAges 18 years+ - NCT07008469Enrolling by invitationPhase 3
Long-term safety study of del-desiran for DM1
This study tests whether the drug del-desiran continues to be safe and effective for people with DM1 (myotonic dystrophy type 1) after they complete an earlier study. You'll receive the drug and have regular check-ups to see how you're doing.
Los Angeles, CaliforniaAges 16 years+ - NCT06845644Recruiting
MRI scans to track nerve damage in neuropathy patients
This study uses MRI scans to look at nerve and muscle changes over time in people with inherited or acquired nerve conditions. It may help doctors better understand how these diseases progress.
MarseilleAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.