Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06491212Recruiting
Flat feet linked to breathing and balance study
This study looks at whether people with flat feet have differences in their diaphragm (a breathing muscle), balance, and foot pressure compared to people with normal arches. It may help understand how flat feet affect overall movement and stability.
Antalya, AlanyaAges 18–30 - NCT06491615Recruiting
eyeGENE study: genetics of rare eye diseases
This study collects DNA samples and medical information from people with rare inherited eye diseases and their close relatives. The goal is to learn more about the genetic causes of these conditions and improve diagnosis and care.
Bethesda, MarylandAges 1 day–120 years - NCT06492473Recruiting
Study of VSD in children at Sohag University Hospital
This study looks at children with a common heart defect called a ventricular septal defect (a hole between the lower heart chambers). The goal is to learn more about how this condition affects children and help guide better care.
SohagAges 1 day–16 years - NCT06494709Recruiting
Eye-tracking study of attention to faces after jaw surgery
This trial uses eye-tracking to measure how people look at faces after jaw surgery (orthognathic surgery). It is designed to help researchers understand changes in social attention following the procedure.
Amiens, PicardieAges 18 years+ - NCT06497153Recruiting
Lung ultrasound for children with sickle cell disease
This study tests whether using lung ultrasound can help doctors quickly spot and treat acute chest syndrome in children with sickle cell disease. It may lead to faster, safer care for kids in the intensive care unit.
ParisAges 1 month–17 years - NCT06497829Recruiting
Geranylgeraniol for MVK deficiency trial
This study tests whether a natural supplement called geranylgeraniol can help people with mevalonate kinase deficiency (a rare metabolic condition). If you are 12 or older and have this diagnosis, you may be able to join.
PragueAges 12 years+ - NCT06497959RecruitingPhase 3
Ultrasound study of placenta blood flow
This trial uses a special contrast dye during ultrasound to examine blood flow in the placenta of pregnant women who have chosen to end their pregnancy for medical reasons. It may help understand the role of poor placental blood flow in severe fetal growth restriction.
NancyAges 18–64 - NCT06498167Recruiting
Rinvoq safety study
This study is checking the safety of the medicine Rinvoq (upadacitinib) in people who have been prescribed it. It involves answering a few questions over the phone to help doctors understand how the medicine is working for you.
PortoAges 18 years+ - NCT06499363Recruiting
Treprostinil for pulmonary hypertension in newborns
This study collects information on how well a medicine called treprostinil works and how safe it is for newborn babies with pulmonary hypertension (high blood pressure in the lungs). It is for babies who have already received this treatment as part of their regular care.
BronAges Up to 10 months - NCT06501547Recruiting
Telomere length and skin aging study
This study looks at your blood cells to see if the length of your telomeres (a sign of cell aging) is linked to how your skin ages. It will help understand why some people's skin ages faster.
Jakarta Pusat, DKI JakartaAges 29–61 - NCT06504433Recruiting
Natural history of mitochondrial diseases
This study follows people with mitochondrial disease over time to learn more about how the condition progresses. It may help researchers find better ways to manage and treat mitochondrial diseases in the future.
Randwick, New South WalesAges 18 years+ - NCT06504589Recruiting
Study for CF treatments for people without modulators
This study tests new treatments for cystic fibrosis in people who cannot take or choose not to take current CFTR modulators. It aims to find better options for managing CF.
Birmingham, AlabamaAges 12 years+ - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT06505603Recruiting
PiMZ alpha-1 deficiency progression study
This study is looking at people with a specific mild form of alpha-1 antitrypsin deficiency (PiMZ) to understand how their lung disease progresses over time. It involves lung function tests and CT scans, and may help researchers learn more about the condition.
Birmingham, AlabamaAges 18 years+ - NCT06506461RecruitingPhase 1
Gene editing for sickle cell disease in young adults
This trial uses gene editing to fix your own blood stem cells, so you can stop having severe sickle cell crises. It is for young adults with frequent pain episodes or who need regular blood transfusions.
Memphis, TennesseeAges 18–24 - NCT06506617Recruiting
Testing pneumonia patients in the emergency room
This trial studies a new testing method (HCAP-Pcr) for people with pneumonia caught in the hospital or other healthcare settings. Doctors will use a special lung washing procedure called bronchoalveolar lavage to quickly identify the cause of the infection, which could help guide treatment faster.
Florence, Tuscany/ItalyAges 18 years+ - NCT06506734Recruiting
Dental color changes and quality of life in early jaundice
This study looks at how early and long-lasting jaundice (high bilirubin levels) affects tooth color and quality of life in children with certain liver conditions. It aims to understand these effects to improve care.
BordeauxAges 12–18 - NCT06507007Recruiting
Inner ear function in Turner syndrome
This study looks at why some people with Turner syndrome have inner ear problems. It uses MRI and CBCT scans to understand the genetic and epigenetic causes.
HerningAges 18–60 - NCT06507072Recruiting
Adaptive rock climbing for kids with arm differences
This study tests whether adaptive rock climbing can help children with arm or hand differences improve their physical function and confidence. It aims to find fun and effective ways to support your child's development.
Los Angeles, CaliforniaAges 6–16 - NCT06507748Recruiting
Measuring pain with a finger device in NF1
This study tests a new way to measure pain and other sensations in people with NF1 using a device that clips onto a finger or toe. The device looks at how your pupil reacts to mild pulses, which may help doctors better understand your pain.
Washington D.C., District of ColumbiaAges 1–120 - NCT06507956Recruiting
Physical activity and sitting habits in adults with cystic fibrosis
This study looks at how physically active and sedentary adults with cystic fibrosis are. It uses a device to measure your daily movement and asks you to fill out a few questionnaires. The goal is to better understand your activity patterns and find ways to help you stay healthy.
Pierre-BéniteAges 18–65 - NCT06509984RecruitingPhase 2
Testing apremilast for genetic EBS with frequent blisters
This study tests whether a daily pill called apremilast can reduce the number of new blisters in people with a genetic form of EBS (epidermolysis bullosa simplex). If you get more than 3 new blisters per day and have a confirmed KRT5 or KRT14 mutation, this trial may be a good fit.
Nice, FranceAges 6–99 - NCT06510881Recruiting
One surgery vs. multiple surgeries for cleft nose and gum repair
This trial compares doing a single surgery to fix both the nose and gum problems caused by a cleft lip and palate, versus doing multiple surgeries over time. It aims to find out which approach works better for children and teens.
AsyutAges 5–18 - NCT06512064Recruiting
Breath sound test for lung health
This study tests a new device that listens to your breathing to check lung health. It is for healthy people and those with asthma, COPD, CF, or other airway diseases.
Indianapolis, IndianaAges 8–70
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.