Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT02604563Recruiting
Aging, blood changes, and health in older adults
This study examines why some older adults develop changes in their blood cells that may affect their health. Researchers will look for links between these blood changes, aging, and common health problems in older people.
St Louis, MissouriAges 50 years+ - NCT04187131Recruiting
AR brain tests and rehab for stroke neglect
This trial tests an augmented reality (AR) system to find and treat “neglect” after an acute stroke. If you qualify, it may help assess attention problems and guide rehabilitation exercises.
Boston, MassachusettsAges 18 years+ - NCT07698951Recruiting
Testing a new device to close PFO after stroke
This trial tests a new device to close a PFO (a small hole in the heart) in people who have had a stroke caused by a blood clot passing through that hole. The goal is to see if the device can prevent another stroke.
BelgradeAges 18–65 - NCT07306182RecruitingPhase 2
Testing SGC001 for anterior wall heart attack
This study tests an investigational drug called SGC001 for people having a heart attack affecting the front wall of the heart. The goal is to see if adding this drug to the standard artery-opening procedure helps improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–79 - NCT07015905RecruitingPhase 3
Study of REGN7508 vs. standard blood thinners after knee replacement
This trial compares a new blood thinner called REGN7508 to two standard blood thinners (apixaban and enoxaparin) to prevent blood clots after total knee replacement surgery. The goal is to see which is safer and more effective.
Sheffield, AlabamaAges 18 years+ - NCT07324031Recruiting
Study of a new under-the-skin defibrillator (the Parasternal EV-ICD)
This study tests a new type of defibrillator that goes underneath the skin, near your breastbone, to protect against dangerous heart rhythms. It may be an option if you need an ICD but haven't had certain prior chest surgeries or devices.
Scottsdale, ArizonaAges 18 years+ - NCT05650632RecruitingPhase 1
IV infusion safety study of etentamig for multiple myeloma
This is an early (Phase 1) study focused on safety of an IV medicine called etentamig in adults with relapsed or refractory multiple myeloma. It looks at how the treatment affects side effects and helps decide the safest way to give it.
Phoenix, ArizonaAges 18 years+ - NCT07230886Recruiting
Reducing transplant complications with enhanced preservation
This trial tests a new way to preserve donated lungs before transplant to lower the risk of complications. It may help primary graft dysfunction, a serious lung problem after surgery.
Toronto, OntarioAges 17 years+ - NCT07523620Recruiting
Heart rhythm procedure with left atrial appendage closure
This trial tests a procedure that closes off a small pouch in the heart (left atrial appendage) while also treating irregular heartbeat (atrial fibrillation) with a catheter ablation procedure. The goal is to reduce your stroke risk and treat your symptoms without needing blood thinners long-term.
Brussels, B CAP RAges 18 years+ - NCT07531251RecruitingPhase 4
Barth Syndrome Heart Treatment Study
This trial tests a medicine called elamipretide (4TAZ) in boys with Barth Syndrome, a genetic condition affecting the heart and muscles. The goal is to see if this medicine can help improve heart function and how the body uses energy.
Needham, MassachusettsAges 5–55 - NCT07355192Recruiting
Group singing for heart health
This study tests whether singing in a group can improve heart health in people with a history of coronary artery disease. If you join, you'll sing with others and see if it helps your heart function.
Milwaukee, WisconsinAges 55–89 - NCT07696390Recruiting
Virtual reality after a heart attack (STEMI)
This trial tests if using virtual reality in the intensive care unit helps people recover after a STEMI heart attack. If you are awake, able to communicate, and have had a stent placed, this could be for you.
VanAges 18–70 - NCT06787729Recruiting
Using sensors and a smartphone to help arm recovery after stroke
This study tests if wearing small sensors on your arm at home and using a smartphone app can help improve how you use your weaker arm after a stroke. It is designed for people who are at least a year past their stroke and want to take an active role in their recovery.
Charlestown, MassachusettsAges 18–80 - NCT06106945RecruitingPhase 1/Phase 2
AZD0305 alone or with other drugs for multiple myeloma
This trial tests a new drug called AZD0305, either by itself or combined with other cancer drugs, for people with multiple myeloma. It aims to see if the treatment is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT07695545Recruiting
Lipid metabolism study in ascending aortic aneurysm
This study looks at how fat metabolism and cell energy centers (mitochondria) work in patients having surgery for an ascending aortic aneurysm. It aims to understand differences between people with bicuspid or tricuspid aortic valves.
DijonAges 18 years+ - NCT05433220Recruiting
Messaging to doctors about treating heart failure
This study tests whether sending guidance messages to your cardiologist improves how heart failure care is provided. It may help patients get the right medication plan, if they are not already on the strongest versions of the standard treatments.
Falls Church, VirginiaAges 18 years+ - NCT07611968Recruiting
Physician-Modified Stent Grafts for Aortic Aneurysms
This trial tests a custom-made stent graft (a tube that reinforces the aorta from inside) for patients with large aortic aneurysms who may be too sick for traditional open surgery. The goal is to prevent rupture and complications while avoiding major surgery.
Jacksonville, FloridaAges 50 years+ - NCT06480591Recruiting
Study of CALR gene changes in blood cancers
This study looks at cells from people with a specific gene change called CALR, found in some blood cancers (myeloproliferative neoplasms). It aims to better understand how the disease works. No new treatments are being tested, but you may help researchers learn more about your condition.
Charlotte, North CarolinaAges 18 years+ - NCT06870760Recruiting
Early blood cancer detection in Charlotte firefighters
This study looks at firefighters to find early signs of blood cancers before they become serious. It aims to learn how to catch these cancers earlier, so they can be treated sooner.
Charlotte, North CarolinaAges 40–49 - NCT05712200RecruitingPhase 3
Abelacimab for atrial fibrillation when blood thinners aren’t suitable
This Phase 3 study tests whether abelacimab can prevent stroke and other blood-clot problems in people with atrial fibrillation (or atrial flutter) who cannot safely take usual mouth blood thinners. It also looks at safety, especially bleeding risk.
Birmingham, AlabamaAges 65 years+ - NCT04934787Recruiting
Balance-feedback ankle rehab after stroke
This trial tests an ankle-foot exercise and training program that gives you balance feedback to improve walking after stroke. It may help reduce foot drop and improve balance and safe walking.
Hong KongAges 18–70 - NCT04937868Recruiting
Guiding CT scans for belly and pelvis injuries after blunt trauma
This study looks at how to make a better decision tool for when to order a CT scan of the belly and pelvis after a blunt injury in the emergency department. It aims to help clinicians choose the right patients for imaging during the first evaluation.
Los Angeles, CaliforniaAges Any age - NCT04937699RecruitingPhase 4
Switching anti-platelet tablets after a heart stent
This trial studies whether changing the timing and type of blood-thinner tablets after a heart stent is as safe and effective as continuing the same plan. It may help some people by simplifying treatment while preventing dangerous clotting after a coronary procedure.
Hangzhou, ZhejiangAges 18–80 - NCT04939207Recruiting
Test safer, cheaper scans for suspected coronary artery disease
This study compares new imaging methods to see how well they work and whether they can lower costs for people with suspected coronary artery disease. It may help by using different scan approaches while keeping patient safety in mind.
Eindhoven, North BrabantAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.