Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05029063RecruitingPhase 3
Rivaroxaban to prevent clots in cancer patients with new catheters
This Phase 3 study tests whether the medicine rivaroxaban can prevent dangerous blood clots in people with cancer who have a central venous catheter placed recently. It may help reduce clot risk while your catheter is in place, but you must meet safety and bleeding-risk criteria.
Halifax, Nova ScotiaAges 18 years+ - NCT05030818RecruitingPhase 4
Study of heart risk changes using a daily polypill
This trial looks at how a daily “polypill” affects coronary (heart blood vessel) risk factors in adults who already take this polypill for prevention after a prior heart event. If you’re eligible, you’ll complete several study visits so the team can compare risk factors over time.
Gijón, Principality of AsturiasAges 18 years+ - NCT05030545RecruitingPhase 4
PET/CT study of spironolactone or eplerenone in primary aldosteronism
This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.
Boston, MassachusettsAges 18–85 - NCT05030987Recruiting
Renal denervation for heart failure with preserved heart strength
This trial studies whether a procedure that calms overactive kidney nerves (renal denervation) can improve symptoms and heart function in people with heart failure with preserved ejection fraction. It also checks that the kidney arteries are suitable and that your blood pressure and heart pressure measurements meet the study targets.
Halle, Saxony-AnhaltAges 18–80 - NCT05031897RecruitingPhase 2
Haplo transplant with reduced donor mismatch and radiation
This trial tests a special bone marrow/stem cell transplant approach using a partially matched family donor, along with conditioning treatment that involves radiation. It aims to help treat certain blood cancers by replacing damaged blood-forming cells with new ones from the donor.
Philadephia, PennsylvaniaAges 18 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT05044208Recruiting
Test heart ultrasound and monitoring clues for atrial fibrillation
This study looks at heart ultrasound pictures and heart-rhythm recordings to predict who may develop atrial fibrillation (AF) after a stroke or TIA. If you qualify, your results may help doctors better spot people at higher risk earlier.
TullnAges 18 years+ - NCT05044273Recruiting
Study of two new stents and their safety in adults
This study checks how safe and effective two types of heart stents (Synergy XD and Synergy Megatron) are after they are placed. You might consider it if you’re an adult getting one of these stents and can follow required clinic visits.
AnyangAges 19 years+ - NCT05046002Recruiting
COVID vaccine heart inflammation symptom registry
This study is a “registry,” meaning it collects medical information about people who develop possible heart inflammation after a COVID-19 vaccine. It may help doctors understand how often this happens and which findings are linked to it.
Ottawa, OntarioAges 5 years+ - NCT05047198RecruitingPhase 3
Catheter procedures to stop dangerous heart rhythm episodes
This study compares two catheter-based procedures to treat ventricular tachycardia (VT), a fast, dangerous heart rhythm. It looks to see which approach works better at reducing repeat VT events in people with weakened heart pumping.
Ottawa, OntarioAges 55 years+ - NCT05046483Recruiting
Blood sugar study after a new heart attack
This study measures how your body handles sugar and related hormones in people after a new STEMI heart attack, and compares them with people who do not have diabetes or have prediabetes. The goal is to better understand metabolic changes after the event, which could help future care.
Düsseldorf, North Rhine-WestphaliaAges 18–80 - NCT05048004Recruiting
Test of a heart procedure during atrial fibrillation ablation
This trial studies whether adding a specific technique during a first-time catheter ablation for atrial fibrillation can improve safety or outcomes. It may help doctors understand risks related to small blood clots during the procedure.
BerlinAges 18 years+ - NCT05050617Recruiting
Ultrasound in the ER to predict risks in pulmonary embolism
This trial checks whether a bedside ultrasound done in the emergency room can help predict which people with an acute pulmonary embolism are more likely to have bad outcomes. If you qualify, your care team will compare ultrasound findings with your later results to see if it can guide treatment decisions sooner.
York, PennsylvaniaAges 18 years+ - NCT05051254Recruiting
Breathing muscle testing in children with breathing muscle weakness
This study looks at how hard it is for children to breathe and how their breathing muscles work, using specific breathing-related tests. It may help doctors better understand breathing problems and choose care more effectively.
ParisAges birth–17 years - NCT05051917Recruiting
Tests treatment in adults with acute heart symptoms and artery swelling
This trial studies how to treat people who recently had acute coronary symptoms (like a heart attack or unstable angina) and who also have enlarged or swollen coronary artery segments (coronary ectasia or true aneurysm). It may help by testing a specific approach for reducing risks related to these abnormal artery changes.
Forlì, FCAges 18 years+ - NCT05052606Recruiting
Turner syndrome patient registry study
This is a registry study that collects health information from people who have Turner syndrome. It helps researchers better understand the condition and guide future care.
Aurora, ColoradoAges Any age - NCT05053607Recruiting
Text and Fitbit monitoring during isatuximab treatment
This trial follows people with multiple myeloma who are getting isatuximab through a vein (IV). It tests how well real-world health tracking (text/app messages and Fitbit data) works during treatment, and whether it can help care teams understand your experience.
Houston, TexasAges 18 years+ - NCT05054985Recruiting
Stent graft for thoracoabdominal aortic aneurysm
This trial tests a specialized multi-branch stent graft to treat a large or growing aneurysm in the aorta near the chest and abdomen. It mainly looks at safety and whether the stent keeps blood flowing to important arteries.
Beijing, Beijing MunicipalityAges 18–80 - NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
Chandler, ArizonaAges 18 years+ - NCT05055830Recruiting
Study blood drug levels in critically ill children
This trial measures how the study medicines move through the body and how they affect the child in the Pediatric Cardiac Intensive Care Unit. It may help doctors choose safer and better dosing for critically ill children.
Durham, North CarolinaAges birth–20 years - NCT05056129Recruiting
Phone game to help you manage heart failure
This trial tests whether a sensor-connected digital game (played on a phone) can help people manage heart failure day-to-day. It’s for adults who recently needed hospitalization and are able to do light activity and use a phone.
Austin, TexasAges 45 years+ - NCT05058612RecruitingPhase 4
Midodrine to reduce drip medicines in ICU patients
This trial studies whether midodrine can help some ICU patients need less (or stop) a blood-pressure “drip” called vasopressors earlier. It’s meant to see if starting midodrine sooner can speed recovery and reduce how long you need these medicines.
Edmonton, AlbertaAges 18 years+ - NCT05061004Recruiting
Testing a new mitral valve treatment delivered through a catheter
This trial tests a new mitral valve device that may improve blood flow in people with significant mitral valve leakage or narrowing, using a catheter instead of open-heart surgery. It’s meant for patients who doctors think this catheter approach is a better fit than surgery.
Phoenix, ArizonaAges 18 years+ - NCT05063955Recruiting
Study muscle changes in people with heart failure
This study looks at the reasons for age-related muscle loss (sarcopenia) in people with heart failure. It may help researchers understand what is causing muscle weakness and how it could be treated in the future.
Aarhus NAges 18–90
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.