Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05749250Recruiting
Ultrasound treatment for severe leg artery disease ulcers
This trial studies a specific ultrasound-based treatment aimed at improving healing of severe circulation-related ulcers in the legs. It may help if you have poor blood flow and a wound that hasn’t improved despite usual care.
Charlottesville, VirginiaAges 18 years+ - NCT05750147Recruiting
Study for cardiomyopathy linked to family or genes
This study looks at people with cardiomyopathy (or related heart muscle conditions) and those who may be at risk because of family history or genetic test results. It may help researchers better understand who is likely to develop the condition and how best to monitor or support them.
LondonAges Any age - NCT05752383Recruiting
Study of how cardiogenic shock patients do in the ICU
This study looks at what happens to people with cardiogenic shock while they are in the intensive care unit (ICU), including how their heart and blood circulation change over time. It may help doctors better understand the course of illness in this specific type of shock and improve care.
AmiensAges 18 years+ - NCT05753059RecruitingPhase 1
Study why some water pills stop working in heart failure
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
New Haven, ConnecticutAges 18 years+ - NCT05756244Recruiting
Managing blood thinners during pregnancy to prevent clot problems
This study looks at the best way to manage blood thinners (like injections of LMWH) during pregnancy for people who need them because of a past or current blood clot risk. It may help by improving how safely and effectively anticoagulation is handled to reduce clot complications.
Durham, North CarolinaAges 18–60 - NCT05756257Recruiting
MRI study of blood pressure swings after ischemic stroke
This trial looks at whether changes in blood pressure after an ischemic stroke (a stroke caused by blocked blood flow) are linked to recovery and outcomes. You may be asked to have MRI scans soon after arriving to help researchers understand who is at higher risk and why.
New Haven, ConnecticutAges 18 years+ - NCT05756309Recruiting
ECG patch test to improve heart rhythm detection in kids
This study checks whether a wearable ECG patch can correctly record heart electrical signals and help identify abnormal rhythms (arrhythmias) in children. If it works well, it could make future heart rhythm monitoring more accurate for pediatric patients who need regular Holter (long ECG) monitoring.
SeoulAges 4 weeks–19 years - NCT05757505Recruiting
Intracranial stent for narrowed brain arteries after symptoms
This trial studies whether an intracranial stent (a small mesh tube placed inside the brain artery) improves outcomes and safety for people with severe, symptomatic narrowing of brain arteries. It may help if symptoms continue despite antiplatelet medicine or if blood flow to the brain is poor.
Luoyang, HenanAges 18–75 - NCT05758662Recruiting
PET-CT and heart ultrasound study valve changes after TAVI
This study looks at whether certain valve blood clots (called “subclinical leaflet thrombosis”) and different valve types are linked to valve aging over time. It uses a special PET-CT scan and an echocardiogram to measure changes in the heart valve about five years after TAVI.
CopenhagenAges 18 years+ - NCT05758545Recruiting
Device treatment for diabetic foot ulcers with poor blood flow
This trial tests whether COMS One is safe and effective for healing a specific diabetic foot ulcer. It may help people whose ulcer is not healing well, especially when blood flow to the foot is limited.
Mesa, ArizonaAges 22–90 - NCT05758844Recruiting
Testing a safer backup method during endovascular aneurysm repair
This trial studies whether adding an extra “safe-line” step during endovascular repair of large aortic aneurysms can reduce damage to the spinal cord. It may help lower the risk of spinal cord-related complications during or after the procedure.
PadovaAges 18–100 - NCT05759078RecruitingPhase 4
IV iron treatment after a heart attack for low-iron patients
This trial tests whether giving IV ferric carboxymaltose can lower the risk of death and heart complications after a recent heart attack, and improve quality of life. It is for adults with low iron levels and specific heart/health risk factors identified soon after their heart attack.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18–90 - NCT05759793RecruitingPhase 1
CAR T trial for relapsed myeloma targeting GPRC5D
This Phase 1 trial tests a CAR T-cell treatment made to find a specific marker called GPRC5D on myeloma (or plasma cell leukemia) cells. It may help people whose disease has returned or hasn’t responded to several prior treatments.
ShanghaiAges 18–75 - NCT05759676Recruiting
Diabetes and a new drug-free heart stent after angioplasty
This trial tests whether a polymer-free amphilimus-eluting stent is safe and works well for people with diabetes after a recent heart blockage procedure. It may help improve how well the artery stays open, while tracking side effects over time.
SeoulAges 19 years+ - NCT05760898Recruiting
Helping control blood pressure in people with rheumatoid arthritis
This study aims to improve blood pressure control in adults who have both uncontrolled high blood pressure and rheumatoid arthritis. It may help by testing ways to better coordinate care between primary care and rheumatology.
Durham, North CarolinaAges 18 years+ - NCT05760846Recruiting
Training hand skills after a recent stroke
This study looks at a therapy that helps people with a recent stroke relearn coordinated hand and arm movements. It compares how well motor skill learning works and may help improve functional use of the affected arm.
Yvoir, NamurAges 18–90 - NCT05760924Recruiting
Testing a new heart pacing method for CRT nonresponders
This trial tests whether a different pacing approach called left bundle branch pacing can improve outcomes and heart structure changes in people who did not improve with standard biventricular CRT. It may help some patients with ongoing heart failure symptoms and weak heart pumping.
TomskAges 18–80 - NCT05760885RecruitingEarly Phase 1
Multisensory training to improve standing balance after stroke
This early-stage study tests a multisensory therapy to help people with ongoing balance problems stand more safely after a stroke. It may help your balance by giving targeted feedback to the foot and ankle while you practice standing.
Charleston, South CarolinaAges 21 years+ - NCT05761314Recruiting
Study treatments for cancers in people with RASopathy
This study looks at people who have a RASopathy—a genetic condition—and also have solid tumors (tumor growths not in blood). To join, your RASopathy must be confirmed by genetic testing, not only by symptoms.
RomaAges Any age - NCT05761067Recruiting
Trial for advanced heart weakness with low pumping ability
This study looks at treatment options for adults with significantly reduced heart pumping strength and extensive coronary artery disease. It may help people who are at higher risk due to widespread blocked heart arteries, but eligibility depends on recent heart events and bleeding risk.
GothenburgAges 18 years+ - NCT05762432Recruiting
Wound dressing study for certain diabetic foot ulcers
This study looks at a specific wound dressing in people with a non-infected diabetic foot ulcer that has nerve pain (neuropathic), poor blood flow (ischemic), or both. It may help you heal the ulcer and improve how the wound looks and progresses.
Airdrie, North LanarkshireAges 18 years+ - NCT05762952RecruitingPhase 1
Dapagliflozin study for heart micro-blood-flow symptoms in women
This early-phase study tests whether dapagliflozin can improve tiny blood-vessel function in women who have heart-ache-like symptoms but no major blockage on heart scans. If it works, it may help symptoms related to “microvascular” heart circulation problems.
Charlottesville, VirginiaAges 18–99 - NCT05765175Recruiting
Radioablation versus repeat ablation for hard-to-treat VT
This trial compares a heart procedure using targeted radiation (called radioablation) to a repeat catheter ablation for people with high-risk, hard-to-control ventricular tachycardia (VT). It aims to find which approach is safer and works better after standard ablation and amiodarone have not stopped the abnormal rhythm.
Los Angeles, CaliforniaAges 18 years+ - NCT05763953RecruitingPhase 2
Nasal medicine trial for fast heart rhythm in children
This Phase 2 trial tests whether an at-home nasal spray medicine called etripamil can help children who have episodes of a specific type of fast, irregular rhythm caused by an electrical “AV node” circuit. It mainly targets certain kids with past or confirmed episodes on heart testing.
Phoenix, ArizonaAges 6–17
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
- Digestive system
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- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.