Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05931276RecruitingPhase 3
Beta blocker choice may improve heart outcomes on dialysis
This phase 3 study tests whether a specific beta blocker selection on hemodialysis can improve cardiovascular outcomes. It focuses on certain beta blockers commonly used through the VA pharmacy and compares them in a randomized way.
Long Beach, CaliforniaAges 18 years+ - NCT05931601RecruitingPhase 3
Early blood-pressure support in the emergency department
This Phase 3 study tests whether starting a blood-pressure medicine earlier in the emergency room can improve outcomes for people with low blood pressure or shock. It focuses on patients who have already received enough IV fluids and meet specific blood pressure and lab findings.
CopenhagenAges 18 years+ - NCT05931783Recruiting
Compare two ways to use an artery during heart bypass
This study compares two surgical techniques for heart bypass: using the left internal thoracic artery in one specific way versus another. It may help improve how well the bypass works in people who need bypass surgery for multiple blocked heart arteries.
GrazAges 18–80 - NCT05931614Recruiting
Trial of limited vs normal drinking in heart failure
This study tests whether drinking a different amount of fluid (either more liberal or more restricted) is better for people with heart failure. You may be guided to follow one drinking plan and monitored to see how it affects symptoms and safety.
StockholmAges 18 years+ - NCT05932472RecruitingPhase 4
Compare taking aspirin in the morning vs bedtime
This trial studies whether taking your daily aspirin in the morning or at bedtime changes heart and circulation outcomes. It is meant to see if timing matters for people who already take aspirin every day.
HellerupAges 18 years+ - NCT05932680RecruitingPhase 2
Continue teclistamab for a limited time in responding patients
This Phase 2 trial looks at stopping or limiting teclistamab after you’ve already had a good ongoing response. It aims to see if people can safely continue to benefit while using the medicine for a shorter time.
Little Rock, ArkansasAges 18 years+ - NCT05932602Recruiting
Study of heart pacemaker care under Medicare
This study follows Medicare patients who recently got a specific type of pacemaker to see how coverage works in real life. It may help ensure patients continue to have access to the devices and care they need.
Sylmar, CaliforniaAges 18 years+ - NCT05933720Recruiting
Study drug peptides for blocked leg artery disease
This study tests how well a drug called Slavinorm® (regulatory polypeptides) works and is safe for adults with blocked arteries in the legs due to atherosclerosis. You might be considered if you have confirmed leg artery blockage and can safely do a treadmill walking test.
RyazanAges 18–80 - NCT05934149Recruiting
Lupus health registry that stores samples for future research
This study keeps a long-term record of people with lupus (systemic lupus erythematosus) and collects samples so researchers can study the disease better. You may be able to join if you meet lupus diagnosis criteria, are not pregnant, and can follow the study visits and consent process.
Birmingham, AlabamaAges 18–110 - NCT05934383Recruiting
Ultrasound treatment to lower blood pressure after kidney transplant
This trial tests whether ultrasound “renal denervation” can safely and effectively lower blood pressure in people whose hypertension is not well controlled after a kidney transplant. If you qualify, the study may help you see whether this procedure reduces office and 24-hour blood pressure readings without harming your transplanted kidney.
RotterdamAges 18 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05935007Recruiting
Study for people with an Aveir DR leadless pacemaker
This study uses your medical records from Medicare to learn how the Aveir DR leadless pacemaker performs in everyday life after it’s implanted. It mainly helps researchers and doctors understand real-world outcomes and care needs.
Sylmar, CaliforniaAges 18 years+ - NCT05935605Recruiting
Study pulmonary hypertension in heart failure and valve disease
This study looks at pulmonary hypertension—high blood pressure in the lung arteries—in people with certain heart conditions (heart failure with preserved or reduced pumping function, or significant valve disease). It may help doctors better understand how lung blood pressure changes in these heart problems and guide care.
Rochester, MinnesotaAges 18 years+ - NCT05935709Recruiting
Danish database study for GCA or PMR
This study builds and uses a Danish database for people diagnosed with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). It may help doctors learn more about these conditions over time and improve care.
AarhusAges 50 years+ - NCT05936710Recruiting
Citrate vs acetate dialysis to prevent low blood pressure
This study compares two types of dialysis fluid (citrate-based vs acetate-based) to see which better helps protect blood pressure during intermittent dialysis. It may help people in intensive care who are at risk of dialysis-related low blood pressure.
BéthuneAges 18 years+ - NCT05936606Recruiting
Personalized blood thinner choice after stent placement
This trial tests whether tailoring anti-platelet (blood clot prevention) treatment can better protect people at higher risk of heart or blood-vessel problems after a drug-eluting stent. It may help prevent future clots and complications, especially in patients with certain high-risk health conditions or complex stent/scar tissue features.
SeoulAges 19–80 - NCT05936957Recruiting
Heart failure care study for acute and chronic patients
This study welcomes people with heart failure (both sudden/worsening and long-term). It will check how heart failure care is managed, and it only moves forward if you choose to participate.
Ibadan, Oyo StateAges 18–100 - NCT05937854RecruitingPhase 2
Tadalafil to help breathing in COPD with pulmonary hypertension
This Phase 2 study tests whether tadalafil can improve breathlessness in people with COPD and pulmonary hypertension (high blood pressure in the lungs). It may help you breathe more easily if your symptoms are driven by this specific lung circulation problem.
Aurora, ColoradoAges 35–89 - NCT05937685Recruiting
Lower blood pressure after a heart or stroke event
This trial tests ways to help lower blood pressure in people who have had a heart attack or stroke and are at higher risk for more problems. If your blood pressure is high, the program may help reduce risk by getting it under better control.
Downey, CaliforniaAges 35 years+ - NCT05937880Recruiting
Leflunomide for kids with stubborn Henoch-Schonlein purpura rash
This trial looks at whether leflunomide can calm Henoch-Schonlein purpura (a childhood rash condition) when the rash is hard to control. If standard treatments don’t stop new or worsening rash, this study may offer another option.
Guangzhou, GuangdongAges 1–18 - NCT05938530Recruiting
Sirolimus balloon vs stent graft for blocked arm dialysis access
This trial compares two ways to reopen a blocked “dialysis access” vessel in the upper arm after a clot is treated. It may help keep blood flowing in the access longer and reduce the chance of re-blockage.
SingaporeAges 21–85 - NCT05939700Recruiting
Watching infants after mavacamten use in pregnancy
This study follows people who took mavacamten during pregnancy or breastfeeding to better understand infant outcomes. It may help doctors and families know what to expect and improve safety guidance.
Wilmington, North CarolinaAges 15 years+ - NCT05940350Recruiting
Phone and video coaching after ischemic stroke
This study tests whether tele-rehabilitation coaching delivered by phone or online can help people recover and function better after an ischemic stroke. It may support safer, more consistent rehab guidance from home, tailored through coaching sessions.
AntalyaAges 45 years+ - NCT05942287Recruiting
Weight and weight loss study in heart failure with weak pumping
This study looks at how obesity and weight loss affect people living with heart failure where the heart pumping strength is reduced. It uses heart imaging (MRI) to measure the heart and may help clarify what weight changes do for symptoms and heart function.
Jersey, JerseyAges 18–85
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
- Mouth & dental
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.