Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05916898Recruiting
Shockwave treatment after difficult stent expansion
This registry studies how well shockwave therapy works when a previously placed heart stent does not expand well, especially when the artery is quite calcified. Your care team would use it after other tools to prepare the blockage have not worked.
Legnica, Lower Silesian VoivodeshipAges 18–99 - NCT05917275RecruitingPhase 4
Testing tests to predict how you’ll respond to blood pressure medicines
This study uses blood and other body measurements to predict how well certain blood pressure medicines will work for you. It may help doctors choose the best treatment sooner, based on your personal “multi-omics” (biomarker) results.
NijmegenAges 18–75 - NCT05917717Recruiting
Test a care bundle for adults after witnessed cardiac arrest
This trial studies a “care bundle” approach using special devices to improve care after an out-of-hospital or witnessed cardiac arrest. It may help by standardizing emergency treatment for people right after their heart stops.
Southampton, EnglandAges 18–120 - NCT05918861RecruitingPhase 3
Tested heart-risk drug for people with recent heart-attack genetics
This trial studies whether dalcetrapib can lower future heart and blood-vessel risk in people who recently had an ACS (acute coronary syndrome, often a heart attack or unstable chest pain) and have a specific genetic marker. It may help people like you by targeting a risk pathway related to that genetic background.
Alexander City, AlabamaAges 45 years+ - NCT05919342Recruiting
Screening for early heart failure in primary care or at home
This trial tests whether simple screening using a blood test (natriuretic peptides) plus an ultrasound of the heart (echocardiogram) can find early heart failure sooner. Finding it earlier may help doctors start the right management to prevent it from getting worse.
Cleveland, OhioAges 40 years+ - NCT05919056Recruiting
Check heart disease risk and monitor changes over time
This study helps test a prevention plan for people who are at higher risk of heart disease. It uses regular monitoring to see if early prevention can reduce risk before heart problems happen.
Ningbo, ZhejiangAges 40–79 - NCT05920629Recruiting
Moderate drinking and heart recovery after a recent heart attack
This study looks at whether moderate alcohol intake affects heart function after a recent heart attack. You may be asked to follow a specific plan and attend scheduled visits so researchers can measure changes in your heart and overall recovery.
Basel, BaselAges 18 years+ - NCT05920343RecruitingPhase 2/Phase 3
Preventing blood clots in genitourinary cancer with rivaroxaban
This trial tests whether rivaroxaban, a blood thinner pill, can help prevent dangerous blood clots in people with certain genitourinary cancers who are starting cancer treatment. It may lower clot risk, but it also has bleeding-risk tradeoffs that the study will monitor closely.
Ottawa, OntarioAges 18 years+ - NCT05920824Recruiting
Testing treatment for leaking mitral and tricuspid valves
This trial studies people with atrial fibrillation and moderate-to-severe leakiness in the mitral and tricuspid valves in the heart. It likely aims to improve symptoms and heart function by better addressing how these valve leaks happen.
LondonAges 18 years+ - NCT05921279Recruiting
Study heart events in people with breast cancer
This study looks at what heart-related side effects happen in women with breast cancer who are planned to receive chemotherapy. It may help doctors better understand and monitor these risks during treatment.
GalwayAges 18–90 - NCT05922540Recruiting
Study of ischemic stroke to improve patient care
This study looks at people who have had an ischemic stroke (a type caused by a blocked blood vessel). It is collecting information over time to better understand care needs and follow-up after stroke.
HunanAges 18 years+ - NCT05922501RecruitingPhase 2
Test four medicines for relapsed multiple myeloma
This Phase 2 study tests a combination of medicines (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) for multiple myeloma that has come back or did not respond to prior treatment. It may help by better controlling the myeloma after standard therapies have failed.
Boston, MassachusettsAges 18 years+ - NCT05922644Recruiting
Spinal cord stimulation for consciousness recovery after brain bleed
This trial studies whether short-term spinal cord stimulation can help people regain consciousness after an intracerebral hemorrhage (brain bleed). It’s mainly for patients whose brain function tests suggest they are in a minimally conscious state and who are medically stable enough for the procedure.
Beijing, Beijing MunicipalityAges 18–65 - NCT05922982Recruiting
Guided medicine weaning for low blood pressure after heart surgery
This study tests a method to safely reduce (wean) norepinephrine, a blood-pressure–support medicine, in people who develop low blood pressure after heart surgery. It uses a monitoring index to help decide when it may be safer to lower the dose, aiming to improve recovery and reduce risks.
AmiensAges 18 years+ - NCT05924347Recruiting
Imaging study to spot early spine changes in at-risk children
This study uses MRI and physical measurements to look for early signs of scoliosis (a side-bending of the spine) in children who are at higher risk. It may help doctors understand when scoliosis starts and improve early monitoring.
UtrechtAges 8–11 - NCT05925790Recruiting
Testing immune markers in recurring pericarditis
This study looks at immune blood markers to understand different types of recurring inflammation around the heart (pericarditis). The goal is to see whether certain marker patterns (like IL-1RA antibodies and suPAR) are linked to inflammation and what might be driving it.
HomburgAges 18–90 - NCT05926271RecruitingPhase 2
Genotype-guided clopidogrel alone after stent placement
This trial looks at whether using clopidogrel by itself (without aspirin) works for people after a new drug-eluting stent, based on a blood test of how your body processes the drug. It may help reduce “extra blood-thinning” if you have a certain genetic type that responds well to clopidogrel.
Nieuwegein, UtrechtAges 18 years+ - NCT05927441Recruiting
Heart valve repair/stenting test for leaky mitral valve
This study tests a catheter-based procedure to treat a leaky mitral valve (either FMR or DMR, depending on the group you’re in). It may help reduce symptoms and improve heart function in people who are sick from valve leakage but are able to undergo this specific approach.
BonnAges 18 years+ - NCT05927571RecruitingPhase 1
Cevostamab and elranatamab combination study for relapsed myeloma
This Phase 1 trial tests whether combining two targeted antibody medicines—cevostamab and elranatamab—is safe and whether it shows signs of activity in people whose multiple myeloma has come back or not responded. It’s early-stage, so the main goal is safety, dosing, and how the medicines behave in the body.
Camperdown, New South WalesAges 18 years+ - NCT05928728RecruitingPhase 3
Colchicine for people with certain irregular heartbeats
This trial tests whether colchicine can help people with paroxysmal or persistent atrial fibrillation (AF), a type of irregular heartbeat, after a successful cardioversion. It may help reduce future AF problems, depending on the results.
HellerupAges 18 years+ - NCT05929027Recruiting
At-home gaming and exercise after stroke
This study tests whether an at-home program using gaming and hand exercises can improve arm and hand movement after a recent stroke. It may help you practice more comfortably at home with regular remote check-ins.
Baltimore, MarylandAges 21 years+ - NCT05930899Recruiting
Study tissue and blood samples from heart disease patients
This study builds a biobank, meaning it collects and stores your health information, blood, and possibly heart-related samples to help researchers learn why heart conditions happen. You might join if you have certain heart diagnoses and are having cardiac surgery for a problem other than an aortic valve issue.
Montreal, QuebecAges 19 years+ - NCT05930210RecruitingPhase 3
Study gel treatment for diabetic foot ulcers that won’t heal
This Phase 3 trial tests ENERGI-F703 gel to help heal diabetic foot ulcers that have not improved for at least 4 weeks. It may help some people whose wounds meet specific size and non-infection criteria.
Miami, FloridaAges 18 years+ - NCT05930145Recruiting
Two clot-retrievers versus one for acute stroke treatment
This trial compares using two clot-retrievers at the same time versus using just one to remove the clot in an acute ischemic stroke. It may help find a more effective approach to restore blood flow and improve recovery.
EssenAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.