Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT05636527Recruiting
NEXUS aortic arch stent graft safety study
This study checks how safe and well the NEXUS device works for repairing the aorta in the arch area. You may qualify if you need this type of aortic repair and your health supports the procedure.
BrusselsAges 18 years+ - NCT05335174Recruiting
Predicting low blood pressure after major surgery
This study looks at how to predict low blood pressure in the recovery room (PACU) after certain major surgeries. It may help the surgical team recognize risk earlier so they can respond sooner to protect you during recovery.
Montreal, QuebecAges 45 years+ - NCT05388682Recruiting
Treating Takayasu disease with lung artery involvement
This trial studies treatment for people with Takayasu arteritis when it affects the lung arteries. It may help reduce problems caused by narrowed or involved lung arteries.
BeijingAges Any age - NCT05570552Recruiting
Testing health impacts in adults from smoky, arsenic-exposed homes
This study follows adults who took part in an earlier GEOHEALTH study and live in homes that use traditional stoves, with low-to-moderate arsenic exposure in drinking water. It aims to understand how these environmental factors affect health, and what changes might be possible.
DhakaAges 25–70 - NCT05490238Recruiting
Wrist vs arm access for complex heart procedures
This study compares using the wrist (radial artery) versus a different access site (conventional radial access approach) during complex, larger “bore” heart procedures to open blocked coronary arteries. It aims to see which approach is safer and works better for challenging cases like chronic blockages or heavily calcified arteries.
ArlonAges 18 years+ - NCT05470686Recruiting
Heart surgery patients: link oxygen levels to lung ultrasound
This study checks how well a lung ultrasound score matches oxygen levels after heart surgery. It may help clinicians monitor breathing problems using ultrasound and guide non-drug breathing and therapy care.
Vandœuvre-lès-NancyAges 18 years+ - NCT05499637RecruitingPhase 2
PET/CT scan using a special tracer for heart inflammation
This Phase 2 study tests whether a PET/CT scan using a radioactive tracer can help evaluate acute heart inflammation. It may help doctors better identify inflammation and guide follow-up, especially in people suspected of specific heart inflammation conditions or recently after heart transplant follow-up.
Lausanne, Canton of VaudAges 18 years+ - NCT05316571Recruiting
Lifestyle trial to reduce sitting and improve heart health
This study tests whether breaking up long periods of sitting can improve whole-body cardiovascular (heart and blood vessel) health. You may qualify if you’re currently quite sedentary but otherwise able to walk and climb stairs.
Chapel Hill, North CarolinaAges 30–60 - NCT05411445Recruiting
Study blood markers in blocked grafts after bypass surgery
This study looks at small particles in your blood to understand why bypass grafts can become blocked after coronary bypass surgery. It may help doctors better monitor and treat this complication by relating blood markers to what happens after surgery.
Cotignola, RavennaAges 40–80 - NCT05283174Recruiting
Blood thinner use during stroke to predict outcomes
This study looks at how people doing well on certain blood thinners do when they have a stroke or bleeding while taking them. It will measure medication levels in your blood to understand stroke severity and recovery in the short and long term.
TaipeiAges 20 years+ - NCT05390411Enrolling by invitation
Training to improve how advanced heart failure therapies are chosen
This study tests a program that helps care teams make more consistent, fair decisions about advanced heart failure treatments like heart transplants and mechanical heart pumps. It focuses on how professionals are trained and evaluated, not on patients receiving a new medicine.
Indianapolis, IndianaAges 18 years+ - NCT05617196Recruiting
Virtual pre-surgery rehab for TAVI clinic patients
This study tests a virtual “prehab” program (coaching and preparation before a TAVI heart valve procedure) for people getting treated at the TAVI clinic. It may help you get ready better for the procedure and recovery using phone or online support.
Halifax, Nova ScotiaAges 50–100 - NCT05490901Recruiting
Test exercise heart pressure measurements with an ultrasound
This study looks at how well two heart tests taken during exercise—direct heart pressure measurement and an ultrasound—can explain shortness of breath with activity. It may help doctors better diagnose what’s causing your symptoms.
SeoulAges 19 years+ - NCT05553886RecruitingPhase 3
Tablets for chronic heart failure with low pumping strength
This Phase 3 study tests whether S086 tablets can improve treatment for people with chronic heart failure where the heart pumps weakly. You may be eligible if your heart failure symptoms are moderate to severe and your condition is stable on current medicines, but not if you’ve recently had certain heart events or can’t take related blood-pressure/heart drugs.
Shenzhen, GuangdongAges 18 years+ - NCT05551780Recruiting
Study for treating calcium blockages in leg artery disease
This trial tests a treatment approach for certain long-lasting, calcium-heavy blockages in the leg arteries that have no normal blood flow past the blockage. If you have these “total occlusions” and symptoms like walking pain or critical limb symptoms, this study may offer a new way to open the artery and restore blood flow.
Fort Lauderdale, FloridaAges 19 years+ - NCT06645535Enrolling by invitation
Gut Bacteria and Blood Substances in Stiff Heart Failure
This study looks at how bacteria in your gut and certain substances in your blood relate to a type of heart failure called HFpEF (where the heart is stiff and doesn't relax well). It may help doctors understand the condition better and find new ways to treat it.
Naning, JiangsuAges 18 years+ - NCT05621070RecruitingPhase 3
Test drug JS002 for high cholesterol not at goal
This Phase 3 study tests whether JS002 alone can lower LDL “bad” cholesterol in people whose levels are still too high for their heart-risk level. It will also check how safe the treatment is, especially for heart and metabolic side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT05386277Recruiting
Testing safety of an embolectomy catheter used during clot surgery
This study follows patients who are having surgery to remove a blood clot in an artery or vein and where a specific clot-removal catheter (the LeMaitre TufTex Single Lumen) is used. It aims to confirm how well the device works and monitor safety outcomes.
GenkAges 18 years+ - NCT04731155RecruitingPhase 4
Test early PCSK9 medicine to prevent heart problems after a heart attack
This trial studies whether starting a cholesterol-lowering medicine called a PCSK9 inhibitor early after a heart attack can improve heart health and outcomes. It focuses on people who had a recent heart-artery procedure to fix the blockage in the left anterior descending (LAD) artery.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT04754022Recruiting
Blood use during heart surgery in younger adults
This study looks at how much donated blood (blood products) is needed for younger adults during heart surgery that uses a heart-lung machine. It may help doctors choose safer, more appropriate blood-saving plans for people like you.
Portland, MaineAges 18–65 - NCT04935021RecruitingPhase 4
Study of ATTR cardiac amyloidosis in patients and gene carriers
This study looks at ATTR cardiac amyloidosis (a condition caused by an inherited protein change) in people who have the disease or carry the gene. It may help researchers learn how ATTR affects the heart and how care can be improved.
Hangzhou, ZhejiangAges 18–80 - NCT05255172Enrolling by invitation
Exercise program for heart failure with preserved or reduced pumping
This trial tests whether a structured exercise program can help people with heart failure. It focuses on people who are currently not very active, aiming to improve symptoms and heart/fitness measures safely.
LundAges 50–90 - NCT05259150Enrolling by invitation
Health for Hearts program for Black adults
This study is testing a community health program aimed at improving heart health. It is designed specifically for Black adults and looks at whether the program is helpful for people like you.
Tallahassee, FloridaAges 18 years+ - NCT05140525RecruitingPhase 3
BPA plus CTEPH medicines to improve heart strain
This trial tests whether starting specific medicines for CTEPH and then doing balloon pulmonary angioplasty (BPA) can improve how well the right side of the heart is working. It may help people who cannot have surgery (PTE) and are newly starting CTEPH/PAH-targeted treatment.
Durham, North CarolinaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.