Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,784 recruiting studies in this area right now.
By phase
- Not applicable6,423
- Phase 2495
- Phase 1249
- Phase 3240
- Phase 4214
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety388
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder240
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress118
- PTSD104
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development102
- Yale University87
- Massachusetts General Hospital79
- Stanford University69
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts269
- New York254
- Texas209
- Maryland175
- Pennsylvania170
- Florida148
- Alabama119
- Arizona111
- Ohio104
Recruiting studies7,784 total
- NCT03918577Recruiting
Caloric stimulation to help thinking in OCD spectrum
This trial studies whether a gentle inner-ear stimulation can change how people experience troubling thoughts in OCD-spectrum conditions. If you have strongly held intrusive worries related to these conditions, the study may help see whether this approach can reduce their impact.
Stanford, CaliforniaAges 18–65 - NCT03915418Recruiting
Screening sleep problems in children with cerebral palsy
This trial checks a new way to find sleep problems in children with cerebral palsy using connected tools (like devices/apps). It mainly helps by making sleep screening easier and more accurate, so families can get the right next steps sooner.
AngersAges 6–15 - NCT03901924Recruiting
Ventilator settings to protect the breathing muscle
This study looks at a specific way to control a breathing machine (ventilator) to help prevent weakness of the diaphragm, the main breathing muscle, in newly intubated adults. You might be considered if you are newly on a ventilator for less than 36 hours and certain other conditions are not present.
Chicago, IllinoisAges 18 years+ - NCT04004169Recruiting
Closed-loop deep brain stimulation for long-lasting depression
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
San Francisco, CaliforniaAges 22–70 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT03914664Enrolling by invitation
Brain and sensation study in adults with Tourette syndrome
This study looks at brain activity and how sensory experiences feel in adults with Tourette syndrome. It compares you to carefully matched adults without neurologic or psychiatric conditions to understand what is different in the brain.
Nashville, TennesseeAges 18 years+ - NCT03971487RecruitingPhase 1/Phase 2
Ocrelizumab for psychosis linked to an overactive immune system
This Phase 1/2 study tests ocrelizumab, a medicine that affects parts of the immune system, to see if it can improve psychosis symptoms in people with schizophrenia-spectrum disorders. It’s mainly for younger adults with ongoing psychosis and evidence that the symptoms began early in life, with certain infection/vaccine safety requirements.
Houston, TexasAges 18–35 - NCT03896529Recruiting
Study how aging and stress affect memory navigation
This study uses brain imaging (MRI) and controlled stimulation to understand how normal aging and stress affect memory and thinking, including how people navigate. It may help researchers learn what changes in the brain happen over time and with stress.
Atlanta, GeorgiaAges 65–80 - NCT03911726Recruiting
Brain imaging study of antipsychotic effects in schizophrenia
This study uses PET and MRI scans to see how antipsychotic medications affect the brain's dopamine system in people with schizophrenia, compared to healthy individuals. It may help understand if these medications cause changes that lead to worsening symptoms over time.
Mannheim, Baden-WurttembergAges 18–65 - NCT03952962Recruiting
Brain stimulation trial for depression that hasn’t improved
This trial tests a targeted deep brain stimulation procedure to reduce symptoms in people with long-lasting, treatment-resistant depression. It may help by improving mood symptoms using stimulation guided by detailed brain imaging.
Dallas, TexasAges 21–70 - NCT03970005Enrolling by invitation
Step-based program for teens with early signs of psychosis
This trial tests a staged (“step-based”) mental health program for people ages 12–25 who have early warning signs that could develop into psychosis. It may help by targeting symptoms early and reducing the chance of worsening over time.
Columbus, OhioAges 12–25 - NCT03912194RecruitingPhase 3
Training to help you quit smoking sooner and feel better
This Phase 3 study tests a quit-training program that teaches how to handle urges and negative feelings when you start cutting back or stopping smoking. You may benefit by improving your chances of quitting and reducing stress during withdrawal.
Birmingham, AlabamaAges 18 years+ - NCT04007432Recruiting
Testing nighttime low-oxygen levels after hip fracture surgery
This study checks how often older adults get low oxygen during the night after hip fracture surgery. It may help doctors better monitor and improve care during hospital recovery.
ParisAges 70 years+ - NCT03836950RecruitingPhase 1/Phase 2
Brain stimulation to improve thinking in Parkinson’s
This trial studies a noninvasive treatment called rTMS to help improve thinking and memory in people with Parkinson’s who have mild cognitive problems. It may help strengthen brain function, but it also has strict safety and eligibility rules to protect against seizure and metal-related risks.
Chicago, IllinoisAges 50 years+ - NCT03720613Recruiting
Testing medicines to prevent heart events in opioid constipation
This study looks at how well naldemedine (and certain other constipation medicines) lower the risk of major heart problems in people who take opioids for constipation. It compares medicine use patterns in people with opioid-induced constipation to see who has fewer serious heart events.
Wilmington, DelawareAges 18 years+ - NCT03769259Enrolling by invitation
Therapy for recent suicidal thoughts or attempts
This study tests a brief counseling approach based on cognitive behavioral therapy to help people who are dealing with suicidal thoughts or a recent suicide attempt. It’s offered in outpatient care and aims to see whether this shorter therapy works for improving safety and coping.
Jacksonville, North CarolinaAges 18 years+ - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT03866668RecruitingPhase 2
Esomeprazole for young children with autism
This Phase 2 study tests whether esomeprazole helps children with autism. It looks at children who are generally healthy, take stable medicines, and can reliably attend visits so their care team can track changes during the study.
Stanford, CaliforniaAges 2–6 - NCT03836300Enrolling by invitation
Parent-infant coaching for families with young diagnoses
This study tests a parent-and-infant coaching program for babies and caregivers. It aims to see whether the program helps after an early diagnosis when English is used at home.
Research Triangle Park, North CarolinaAges Up to 99 years - NCT03777267Recruiting
Test a brain-sensing device for stress, anxiety, or insomnia
This exploratory study tests how a wearable brain-sensing setup (with sensor leads/earbuds) works for people with stress, anxiety, or sleep problems. You may be asked to sit still during sessions and complete brief questionnaires to confirm your symptoms.
Winston-Salem, North CarolinaAges 11 years+ - NCT03794076RecruitingPhase 1/Phase 2
Testing adjunct cromoglicate for schizophrenia symptoms
This trial studies whether adding cromoglicate to your usual antipsychotic medicine can improve schizophrenia symptoms. It’s designed for outpatients who are already on a stable treatment and still have certain ongoing symptom scores.
Pittsburgh, PennsylvaniaAges 18–65 - NCT03827460RecruitingPhase 1
Study tests how men and women respond to alcohol abstinence
This Phase 1 study looks at sex differences in how the body and brain respond when people stop drinking alcohol for a short time. You may be asked to complete questionnaires and provide blood samples to measure changes during the abstinence period.
Indianapolis, IndianaAges 21–35 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT03809351RecruitingPhase 1
Brain tau scan add-on for people in the UAB Alzheimer studies
This trial tests an added brain imaging scan that looks for “tau” protein in people already enrolled in the UAB Alzheimer research studies. Results may help researchers better understand Alzheimer’s disease and improve future diagnosis.
Birmingham, AlabamaAges 50 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,784 recruiting psychiatry studies from the U.S. registry right now, out of 12,489 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.