Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06526572Recruiting
Pain measurement with brain waves in tooth infection
This trial tests a new way to measure pain from a tooth infection using brain wave recordings (EEG). It may help people whose numbing injection doesn't work well.
Cleveland, OhioAges 18–50 - NCT07020650Enrolling by invitation
Bone graft for preserving jawbone after tooth removal
This study tests whether a special bone graft material (carbonate apatite) helps preserve the jawbone after a tooth is removed, so you can later get a dental implant. It's for people who need a tooth pulled and are interested in getting an implant.
Ann Arbor, MichiganAges 20–80 - NCT06532916Recruiting
Comparing two tooth-colored filling materials for small cavities and wear
This study tests two types of tooth-colored filling materials (a flowable one and a preheated one) to see which keeps its color and resists wear better. It may be a good option if you have a small cavity, chip, or natural wear on a front tooth or the side/back of a tooth.
IrbidAges 18 years+ - NCT06105489Recruiting
Comparing two sinus lift surgery techniques
This trial compares two surgical methods for lifting the sinus membrane to add bone for dental implants. It may help if you have very little bone left in your upper jaw back teeth area.
PadovaAges 18 years+ - NCT07208812Recruiting
3D-printed lower dentures: comparing impression methods
This study compares two ways of making dental impressions for 3D-printed overdentures (removable tooth replacements held by implants). It looks for people who need new lower-jaw implants and are otherwise healthy.
Al Mansurah, Dakahlia GovernorateAges 45 years+ - NCT06846619Recruiting
Testing two ways to make 3D-printed dentures
This study compares two methods for making 3D-printed dentures to see which patients like better. It aims to find which technique is more comfortable and satisfying.
CairoAges Any age - NCT07704151Enrolling by invitation
Zirconia crowns for damaged first permanent molars
This study compares custom-made and prefabricated zirconia crowns for children whose first permanent molars are badly damaged by cavities or a condition called molar-incisor hypomineralisation (MIH). It aims to see which type of crown works better.
IrbidAges 7–13 - NCT07199153Recruiting
3D printed guide for precise front tooth implant placement
This study tests a new 3D printed guide that helps place a dental implant precisely in the front part of your upper jaw. If you have a single missing tooth there and good bone quality, this approach may offer a more accurate and less invasive treatment.
CairoAges Any age - NCT07198282Recruiting
Comparing gum closure methods after wisdom tooth removal
This study compares two different ways of closing the gum after removing an impacted wisdom tooth. The goal is to see which method leads to less pain, swelling, and faster healing.
Rize, Rize ProvinceAges 18–40 - NCT07194837Recruiting
Laser treatment for root canal retreatment healing
This trial tests whether a special laser (810 nm diode) can help heal infections around the root tip after a failed root canal. It is for people who have a single-rooted tooth that needs retreatment.
CairoAges 20–45 - NCT06543680Recruiting
Comparing two tooth-filling materials for non-cavity neck lesions
This trial compares two types of tooth fillings for wear-and-tear cavities that form near the gum line on the side of the tooth (non-carious cervical lesions). It tests whether a newer self-sticking resin composite works as well as a glass ionomer filling that is often used for these spots.
Al Mansurah, DakahliyaAges 30–60 - NCT07552051Recruiting
Testing Bite Mark Analysis Using 3D Dental Scans
This study tests how accurately dentists can analyze bite marks using digital 3D models of teeth. Researchers will scan your upper teeth and use computer software to see if the same bite-mark patterns are found consistently—helping improve how bite marks are used in dental and legal cases.
Nantes, NantesAges 18 years+ - NCT07183111Recruiting
AI vs. regular instructions for braces patients
This trial compares standard instructions to AI-powered guidance (using a custom ChatGPT) to help patients with braces learn how to care for their teeth. It aims to see which method helps patients follow oral hygiene instructions better.
Islamabad, FederalAges 18–30 - NCT07180849Recruiting
New fluoride varnish vs standard varnish for braces plaque
This trial compares a new fluoride varnish that contains tiny titanium particles (nanoparticles) to a standard fluoride varnish. It tests which one is better at preventing plaque buildup for people getting braces.
IslamabadAges 16–30 - NCT06548516Recruiting
Comparing laser vs scalpel for upper lip gum surgery
This study compares two methods for a gum surgery called a frenectomy (removing a small piece of tissue attaching your upper lip to your gum). It uses either a laser or a traditional scalpel to see which heals better and causes less discomfort.
KonyaAges 18–45 - NCT06864949Enrolling by invitation
Expanding the upper jaw with a preformed brace
This study tests a preformed appliance designed to widen a narrow upper jaw. It may help people whose upper jaw is too narrow, causing their back teeth to cross or tilt inward.
Pavia, LombardyAges 7–13 - NCT07343063Recruiting
Comparing tooth-colored fillings for front teeth cavities
This trial tests different tooth-colored materials for fixing cavities on the front teeth (Class III and IV restorations). It aims to find which type lasts longest and works best for patients in good general health.
Merkez, Rize ProvinceAges 18 years+ - NCT06833034Recruiting
New technique for impacted upper canine teeth
This trial tests a new method to expose an upper canine tooth that is stuck behind the other teeth (palatally impacted). If you have one impacted canine on one side and it's not too high or angled, this study may compare a newer, less invasive exposure technique to the standard approach.
Lund, Skåne CountyAges 10 months–1.5 years - NCT07140146Recruiting
Trehalose vs Glycine air-polishing for gum disease around implants
This trial compares two types of air-polishing powder (trehalose and glycine) to treat gum inflammation around dental implants. It aims to see which is better at cleaning the gum line without damaging implant surfaces.
Pavia, LombardyAges 18–70 - NCT07138287Recruiting
Growth Factor vs Mineral Trioxide for Kids' Permanent Teeth
This study compares two treatments for children’s permanent back teeth with severe, painful nerve inflammation (irreversible pulpitis). It aims to find which approach works better to save the tooth and relieve pain.
MinyaAges 9–16 - NCT07131358Recruiting
Comparing cavity prevention methods in schoolchildren
This trial tests three different methods to prevent cavities in children's back teeth (first permanent molars). It's for kids ages 6 to 8 who are at risk for cavities and attend public schools in Nezahualcóyotl, Mexico.
Nezahualcóyotl, State of MexicoAges 6–8 - NCT07023757Enrolling by invitation
Age and healing after tooth extraction with PRF
This study looks at how age affects healing after a tooth is removed and replaced with a bone graft using Platelet-Rich Fibrin (PRF), a natural substance from your own blood that helps healing. It may help you if you need a molar removed and plan to get an implant later.
Ann Arbor, MichiganAges 20–80 - NCT07114523Recruiting
Collagen membranes for healing after wisdom tooth surgery
This trial tests whether placing a collagen membrane after wisdom tooth removal helps the nearby second molar heal better. If you have impacted lower wisdom teeth on both sides, this study may compare healing with and without the membrane.
Ho Chi Minh CityAges 25 years+ - NCT07111403Recruiting
Testing remineralizing agents for early white spots on teeth
This study tests whether a special remineralizing agent can help reverse early white spots (soft spots) on adult teeth before they become cavities. It's for people who have a few small spots but keep their teeth clean.
Al MansurahAges 14–26
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.