Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07622277Recruiting
Teeth Alignment Stability After Braces: A Retention Study
This study compares how different face types maintain their bite after orthodontic braces are removed. Researchers will use 3D imaging to track whether teeth stay in their corrected positions during the retention phase (when you wear retainers).
Rohtak, HaryanaAges 18–45 - NCT07625423RecruitingPhase 1
Gene therapy injection for advanced head and neck cancer
This trial tests a new treatment where a specially designed virus carrying an anti-cancer gene is injected directly into tumors in the head and neck area. It's for patients whose cancer has come back or spread after prior chemotherapy and who cannot have surgery or radiation.
Chengdu, ChinaAges 18–65 - NCT07628712Recruiting
Treating Tooth Sensitivity With a New Dental Coating
This study tests a new dental coating containing special glass particles to reduce tooth sensitivity and pain. If you have long-lasting sensitive teeth, this treatment might help relieve discomfort.
Hong KongAges 18–69 - NCT07626827Recruiting
3D-Printed Dentures: Digital vs. Hybrid Methods
This study compares two ways of making 3D-printed dentures to see which one fits better, works better, and makes patients happier. It's for people who are completely missing all teeth in both jaws.
Samborondón, GuayasAges 50–90 - NCT07626424Recruiting
Vibration therapy for drooling in children with cerebral palsy
This study tests whether gentle vibration applied to the chin and neck area can reduce drooling in children with cerebral palsy. Drooling affects many children with cerebral palsy and can cause skin irritation; this trial explores a non-surgical treatment option.
VanAges 2–18 - NCT07627295Recruiting
Comparing two tooth fillings for cavities near the gum line
This study compares two types of tooth-colored fillings for cavities that form near the gum line on the front teeth. It aims to see which filling material and polishing method lasts longer and looks better over two years.
Al Mansurah, Dakahlia GovernorateAges 18–35 - NCT06698718Recruiting
Gum color changes after treatment for gum disease
This study uses a special color-measuring tool to see how gum color changes after basic gum disease treatment. It may help find better ways to check if treatment is working.
Hangzhou, ZhejiangAges 18–65 - NCT06700772RecruitingPhase 1
Bone Growth After Sinus Lift for Missing Upper Teeth
This study tests a surgery to build up bone in the upper jaw where teeth are missing. It may help people who need more bone to get dental implants later.
Cairo, New CairoAges 20–50 - NCT06500390Recruiting
TMD and levonorgestrel IUD use study
This study looks at whether using a levonorgestrel intrauterine device (a hormone-releasing IUD) for at least 3 months is linked to jaw joint problems (temporomandibular disorder). It may help women understand potential side effects of this birth control method.
Istanbul, MaltepeAges 18–45 - NCT06543004Recruiting
Comparing pain after root canal with two filling materials
This study is comparing two different materials used to fill the tooth after a root canal to see which one causes less pain afterward. If you need a root canal on a front tooth or a premolar and you don't have pain or swelling, this trial may help find the gentler option for you.
DohaAges 18–60 - NCT06668194Recruiting
Teeth straightening: how much force is best?
This trial tests different force levels to move canine teeth after premolar extraction in teens. Results may help orthodontists choose the best force for faster, safer tooth movement.
Farmington, ConnecticutAges 11–16 - NCT07617480Enrolling by invitation
Orthodontic bracket bonding: acid etching with or without sandblasting
This study compares two methods of preparing tooth surfaces before attaching orthodontic brackets (the small squares glued to teeth during braces treatment). Researchers want to see which method—using acid alone or acid plus sandblasting—keeps brackets bonded better to your teeth.
DhakaAges 18–64 - NCT07615361Enrolling by invitation
Tooth Graft and Laser Therapy for Dental Implants
This study tests whether material from extracted teeth, combined with low-level laser treatment, can help bone heal better before dental implants are placed. The goal is to improve implant success and reduce bone loss after tooth removal.
Istanbul, UskudarAges 18–65 - NCT07613606Recruiting
Platelet-Rich Fibrin Injection for Gum Disease Treatment
This study tests a new injectable treatment using your own blood cells to help repair damaged gum tissue and bone around teeth affected by periodontal disease (gum disease). The goal is to see if this minimally invasive approach can regenerate healthy gum and bone without major surgery.
CairoAges 18 years+ - NCT07618078Recruiting
Personalized Cancer Risk Assessment for Nasopharyngeal Cancer
This study helps doctors predict which patients with nasopharyngeal cancer (a cancer of the upper throat) will benefit most from additional chemotherapy after radiation treatment. It uses a special blood test and imaging to create a personalized risk score for each patient.
Beijing, Beijing MunicipalityAges 18–75 - NCT07619846Recruiting
Chin Bone Rings for Dental Implants in Back Teeth
This surgery uses a special bone ring taken from your chin to build up bone in your back upper jaw, so dental implants can be placed in one procedure instead of two. This may reduce surgery time and help your implants succeed better.
Damascus, GovernorateAges 18–70 - NCT07620184Recruiting
Parotid Gland Surgery With or Without a Drain
This study compares two ways to do parotid gland surgery (removal of a gland in front of the ear). One method uses a drain tube to remove fluid after surgery, and the other does not. Researchers want to see if skipping the drain is safe and improves recovery.
StockholmAges 18 years+ - NCT07614490RecruitingPhase 4
Dental plaque and gum health study
This research study examines how dental plaque relates to gum inflammation in people with different levels of gum health. Researchers will collect plaque samples and measure gum health to better understand these patterns, which may help improve oral care products.
Fort Wayne, IndianaAges 18 years+ - NCT07619729Enrolling by invitationPhase 4
Oral Health Program for People With Type 2 Diabetes
This study tests whether a text-message and online program about caring for your teeth and gums can help people with type 2 diabetes. Researchers want to see if better oral health habits improve overall health outcomes.
Long Island City, New YorkAges 18 years+ - NCT07620353Recruiting
Study of OROSEDAL for sore throat and mouth sores
This study observes how well OROSEDAL, a topical oral medication, works for sore throats and minor mouth ulcers or sores that have lasted less than 15 days. You'll be asked to track your pain relief while using the product your doctor prescribes.
Multiple LocationsAges 8 years+ - NCT06708481RecruitingEarly Phase 1
Resin vs peptide gel for white spots on teeth in children
This study compares two treatments for white spots on teeth: a resin (tooth-colored coating) and a special peptide gel that helps rebuild enamel. It is for children and young teens with early white spots that haven't been treated yet.
Cairo, Giza GovernorateAges 7–14 - NCT06399198Recruiting
Gum graft changes around dental implants
This study looks at how gum grafts change shape around dental implants. If you have a dental implant with thin gum tissue on the cheek side, this could help understand how to improve it.
IstanbulAges 18 years+ - NCT06708377Recruiting
Dry needling and massage for jaw joint pain
This trial tests whether dry needling combined with myofascial massage therapy can help relieve pain and improve jaw movement in people with temporomandibular joint (TMJ) dysfunction. It compares this treatment to standard care to see which works better.
Islamabad, FederalAges 25–45 - NCT06709690Recruiting
AI-powered PET/MR scanner for children with suspected cancer
This study tests a new, fast, and quiet AI-powered PET/MR scanner to take detailed pictures of children with suspected cancer. It aims to make the imaging experience easier and more comfortable for kids.
Shanghai, Shanghai MunicipalityAges Up to 18 years
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.