Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,635
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania21
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06877117Enrolling by invitation
Rectangular collimation study for kid's dentists
This trial tests a new way to focus x-rays (called rectangular collimation) in dental care for children. It may help reduce radiation exposure while still getting clear images.
Toronto, OntarioAges Any age - NCT06396442Recruiting
Patient worries before dental treatment
This study looks at how worried patients feel before dental treatment. If you're about to have a dental visit—like a filling or cleaning—you can take a short survey to share your feelings and help dentists better understand patient anxiety.
Alicante, AlicanteAges 18–100 - NCT07764029Recruiting
Platelet-rich fibrin with bone graft for molar gum disease
This study tests whether using platelet-rich fibrin (a concentrate from your own blood) with a bone graft helps heal gum disease around a lower back tooth. It may improve the support for the tooth and reduce the need for more invasive treatment.
Ho Chi Minh City, Ho Chi Minh City (HCMC)Ages 18 years+ - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT07186673Recruiting
Comparing two types of crowns for back teeth in children
This study compares two ways to fix cavities in children's permanent back molars: a special 'Hall' crown that is placed without numbing or drilling, versus a traditional crown. It aims to see which one works better and is more comfortable for kids.
LatakiaAges 8–15 - NCT07763808RecruitingPhase 2/Phase 3
Gum surgery for receding gums after braces
This study tests different surgical methods to repair receding gums that can happen after orthodontic treatment. If you have gum recession and are otherwise healthy, this trial may help improve your gum health and appearance.
BakuAges 18–70 - NCT07762976RecruitingPhase 2
Tailoring chemo for nasopharyngeal cancer using EBV-DNA and MRI
This trial tests whether adjusting chemotherapy based on tumor markers (EBV-DNA) and MRI scans can improve outcomes and reduce side effects for people with nasopharyngeal cancer. If you have stage II or III disease, this study might help guide your treatment more precisely.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07762651Enrolling by invitation
Tooth-colored fillings for back teeth compared
This study compares two types of tooth-colored filling materials for back teeth. It aims to see which one lasts longer and works better.
Tanta, TantaAges 25–40 - NCT05813236Recruiting
Compare two suture types for gum surgery healing
This trial compares two different types of stitches (suture materials) to see which one works better after gum (periodontal) surgery. It may help by improving comfort and healing in people needing resective periodontal surgery.
Sant Cugat del Vallès, CataloniaAges 18 years+ - NCT06904781Recruiting
Pulp treatment for baby teeth with severe toothache
This study compares two ways to treat severe tooth decay in baby molars: removing only the top part of the nerve (pulpotomy) versus removing all of the nerve (pulpectomy). It aims to see which method works better for saving the tooth and relieving pain.
IrbidAges 4–9 - NCT05946577Recruiting
Links tinnitus and hearing changes after head and neck cancer treatment
This study looks at how tinnitus (ringing in the ears) and hearing problems may develop after radiotherapy alone or with certain chemotherapy for high-risk head and neck cancer. The goal is to better understand who is more likely to experience these side effects.
ParisAges 18 years+ - NCT07696364Recruiting
Testing a mouthwash for gum health
This trial tests a special mouthwash (chlorhexidine) to see how well it prevents gum inflammation. It compares a standard version to one that also reduces tooth staining. You may be eligible if you are healthy, do not smoke, and have at least 24 teeth with healthy gums.
Bern, Canton of BernAges 18–40 - NCT07704905Recruiting
Study on a new toothpaste with stannous fluoride for gum health
This trial tests a new toothpaste containing stannous fluoride to see if it improves gum health. If you have mild gum issues but are otherwise healthy, this study might be a good fit.
Fort Wayne, IndianaAges 18 years+ - NCT06691269Recruiting
Light therapy for pain-free dental care in kids
This study tests a special light therapy called photobiomodulation to see if it can reduce pain during routine dental care in children. It may offer a safe, non-drug way to help kids feel more comfortable at the dentist.
Baltimore, MarylandAges 6–12 - NCT06185075Enrolling by invitation
Dental implant crown design study
This trial tests how the shape of a dental implant crown affects your gum and bone health. It might help you if you have a dental implant that is ready to receive a crown.
Ann Arbor, MichiganAges 20–80 - NCT06944028Enrolling by invitation
Stepwise cavity treatment for deep decay in young teeth
This trial tests a gentler way to remove deep cavities in young permanent molars or premolars, aiming to save more of the tooth and protect the nerve. It may be an option for children and teens with deep decay that hasn't reached the pulp.
StockholmAges 8–19 - NCT06824493Recruiting
How Braces Affect Mouth Bacteria and Saliva
This study looks at how braces (orthodontic treatment) change the bacteria and proteins in your mouth. Healthy volunteers who have never had dental work or cavities are needed to provide saliva samples before and during treatment.
Xi'an, ShaanxiAges 6–18 - NCT06294587Recruiting
Testing the timing of gum grafts for dental implants
This trial studies the best time to do a gum graft (free gingival graft) for people who need dental implants but have narrow jawbone. It compares doing the graft at the same time as other implant procedures versus later, to see which leads to better outcomes.
Birmingham, AlabamaAges 18 years+ - NCT06915038Recruiting
Measuring tumor DNA in blood for HPV-positive throat cancer
This study looks at a blood test that finds DNA from HPV-related throat tumors. It may help doctors decide on surgery and check if the cancer is completely removed.
Carmel, IndianaAges 18 years+ - NCT07758543Recruiting
Facial exercises for improving symmetry in Bell's palsy
This trial tests whether special facial exercises can help people with Bell's palsy regain a more symmetrical face. The exercises focus on muscle control and nerve movement, and may improve recovery when done in the early months.
IslamabadAges 15–60 - NCT05592626RecruitingPhase 1/Phase 2
T cell activator STAR0602 for advanced solid tumors
This study tests an experimental drug called STAR0602 that aims to boost your immune system's T cells to fight advanced solid tumors. It's for patients whose cancer has not responded to standard treatments or for whom such treatments are not suitable.
Sacramento, CaliforniaAges 18 years+ - NCT05122897Recruiting
Study of plaque biofilm on temporary implant crown rings
This study looks at how plaque-biofilm (a thin layer of germs that can stick to surfaces) forms on temporary parts of dental implant crowns. If you have dental implants and are healthy and stable with gum health, your care team may use specific temporary rings to study biofilm buildup.
BaselAges 18 years+ - NCT07041099RecruitingPhase 1
Study of CLN-978 for Sjögren's disease
This trial tests an experimental drug called CLN-978, given as a shot under the skin, that helps your immune system target and destroy disease-causing B cells. It's for people with moderate to severe Sjögren's disease who haven't had success with other treatments.
Orlando, FloridaAges 18 years+ - NCT07504614Enrolling by invitation
Comparing two types of tooth sealants for kids with MIH
This study tests whether a new pre-etched bioactive sealant works better than a standard resin-based one to protect permanent molars affected by molar incisor hypomineralization (MIH), a condition that makes teeth softer and more prone to cavities. It aims to find a more effective way to prevent decay in these vulnerable teeth.
IrbidAges 6–12
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,948 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Blood & lymphatic
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.