Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT05628922RecruitingPhase 2
Blood EBV DNA–guided therapy for advanced nasopharyngeal cancer
This trial tests a treatment approach for people with locally advanced nasopharyngeal cancer using their blood EBV DNA level (a cancer-related virus marker). It may help doctors choose and adjust therapy based on how much of this marker is in your blood after standard treatment.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT04713800Recruiting
Dental implant bridge comparison with two implant types
This trial tests two ways of making a small back teeth bridge (a “cantilever” dental implant crown) using different materials. It may help show which material works best when replacing missing back teeth with implant support.
GenevaAges 22 years+ - NCT05664373Recruiting
Gum recession repair using tissue flap and graft
This trial studies a gum surgery technique to cover multiple areas where the gum has pulled back from the tooth root. It may help improve gum coverage and reduce sensitivity by restoring gum tissue where it is missing.
BelgradeAges 18–60 - NCT05674305RecruitingPhase 3
Tested radiation alone vs added chemotherapy for EBV-negative after treatment
This Phase 3 trial compares giving radiation alone versus giving radiation at the same time as chemotherapy for nasopharyngeal cancer. It focuses on people whose EBV test becomes undetectable after one cycle of chemotherapy, to see which approach works best and is safest.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT04813705RecruitingPhase 2
PET/CT-guided lower-dose radiation for nasopharyngeal cancer
This Phase 2 study tests whether using a special scan (PET/CT) to guide radiation can safely reduce the radiation dose for people with nasopharyngeal cancer. It may help lessen side effects while still treating the cancer effectively.
Taizhou, ZhejiangAges 18–80 - NCT05707819Recruiting
Sintilimab plus chemoradiotherapy for high-risk nasopharyngeal cancer
This trial tests whether adding sintilimab (an immune treatment) to standard chemoradiotherapy can improve outcomes for people with high-risk, locally advanced nasopharyngeal (throat) cancer. It may help your immune system work better against the cancer alongside radiation and chemotherapy.
Nanning, GuangxiAges 18–70 - NCT05707780Recruiting
Testing resin-ceramic crowns for back teeth
This study tests a new type of crown made from resin and ceramic for molars or premolars. If you need a back-tooth crown and your mouth health is in good shape, you may be asked to receive and have it evaluated over time.
MadridAges 20–80 - NCT01958762Recruiting
Cigarette buyers get oral cancer screening
This trial tests whether people who recently bought cigarettes can be offered screening for oral (mouth) cancer. It may help find cancer or warning changes earlier in people at higher risk from smoking.
Amiens, PicardieAges 30–75 - NCT05717790Recruiting
Nimotuzumab with chemo and radiation for advanced nose cancer
This trial tests whether adding nimotuzumab (an anti-EGFR antibody) to standard chemotherapy and radiation can improve outcomes for people with advanced nasopharyngeal carcinoma. It may help the cancer respond better and control it more effectively after treatment.
Baise City, GuangxiAges 18–70 - NCT05741749Recruiting
Immediate dental implant placed right after tooth removal
This study tests a way to place a dental implant immediately after removing a hopeless back tooth, and to help the gums and bone heal better. It may help people who have enough healthy gum and bone and can follow strict mouth-care rules.
LiègeAges 18–99 - NCT02137824Recruiting
Sinus bone lift procedure for people with limited jaw bone
This pilot study tests a modified technique to add bone in the upper jaw area (the sinus floor) so dental implants may be possible. You may be considered if you have a small amount of remaining bone height and enough bone width, and you do not have certain infections or risk factors.
ViennaAges 18–100 - NCT05772208RecruitingPhase 3
New treatment plan for nasopharyngeal cancer after EBV DNA stays detectable
This Phase 3 trial tests a stronger treatment approach for people with locally advanced nasopharyngeal cancer whose EBV “DNA” (a cancer-related virus signal in blood) does not go away after one cycle of chemotherapy. It may help improve outcomes by changing treatment based on how the cancer responds early.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05775679Recruiting
CLEFT-Q survey study for people with cleft lip or palate
This study tests how consistently and clearly a questionnaire (CLEFT-Q) measures your symptoms and how well treatment helps. It may help researchers improve care for people who need a planned second surgery for the nose, lips, jaw, or speech.
Malmö, Skåne CountyAges 8–29 - NCT03385720Recruiting
Saving the submandibular gland during neck surgery
This study looks at whether a specific way of doing neck surgery can help preserve the salivary gland under your jaw in people with early-stage mouth cancer. It may reduce side effects related to saliva, while treating the cancer.
Beijing, Beijing MunicipalityAges Up to 90 years - NCT05038865Recruiting
How jaw alignment affects teens’ quality of life
This study compares how different types of bite/jaw alignment affect adolescents’ daily comfort and oral-health-related quality of life. It’s mainly done by asking teens to complete questionnaires and comparing groups with and without malocclusion.
Malmö, Skåne CountyAges 12–19 - NCT05821140Recruiting
Assessing jaw and bite function in children with oral health issues
This study looks at how a child’s mouth, jaw, and biting function work in different dental and oral health situations. It may help clinicians better understand what support or treatments children need.
Clermont-FerrandAges 3–17 - NCT05838365RecruitingPhase 4
Earlier vs later placement of single tooth implants
This study compares two timing approaches for placing a single implant tooth: putting the implant load (chewing force) on it sooner versus later. It may help show which timing works best for healing and long-term comfort in people with suitable bone and gum tissue.
MilanAges 18–80 - NCT03969628Recruiting
Testing two ways to check tooth-caries risk in children
This study compares two different methods of estimating how likely a child is to get tooth decay. If you visit the children’s dental clinic, the researchers will use these methods to help identify risk and plan prevention.
Pelotas, Rio Grande do SulAges 7–11 - NCT05527470RecruitingPhase 3
Chemo then radiation for newly diagnosed advanced nasopharyngeal cancer
This Phase 3 trial tests giving chemotherapy first, then either radiation alone or chemotherapy together with radiation. It aims to improve treatment control for people with newly diagnosed, advanced nasopharyngeal cancer.
Guilin, GuangxiAges 18–65 - NCT04166695Recruiting
Testing long-lasting partial dentures for back teeth
This study looks at how well a specific type of fixed partial denture works over about 3 years. It may help people missing two back teeth next to each other by improving comfort and chewing with a stable dental replacement.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT04019548RecruitingPhase 3
Test swallowing and quality of life during chemo-radiation for throat cancer
This study looks at how well people swallow and how their quality of life changes during standard chemo-radiation for newly diagnosed throat (oropharyngeal) cancer. The goal is to better understand swallowing side effects so care can improve.
BrusselsAges 18 years+ - NCT05655247Recruiting
Comparing two gum treatments for multiple exposed tooth roots
This trial compares two types of gum surgery to cover exposed tooth roots when you have multiple adjacent gum recessions. It aims to find which approach works best for root coverage and long-term gum health.
TarantoAges Any age - NCT05854849RecruitingPhase 3
Testing three-drug therapy versus cisplatin for recurrent NPC
This trial studies whether gemcitabine plus camrelizumab plus apatinib works better than cisplatin alone for people with recurrent or metastatic non-keratinizing nasopharyngeal cancer. It’s meant for people who haven’t had prior whole-body (systemic) treatment for the returning/spreading cancer.
Guangzhou, GuangdongAges 18–75 - NCT05375266Recruiting
Study of immune signals in head and neck cancer
This study looks at “immune signals” in blood, saliva, and stool to learn more about head and neck cancers (especially squamous cell carcinoma). It may help researchers find patterns that improve understanding of disease or how treatment should be guided.
Erlangen, BavariaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.