Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07006610Recruiting
Tape or cooling therapy for jaw surgery recovery
This study tests whether cooling with a hilotherapy device or taping with kinesio tape helps reduce swelling and pain after double-jaw surgery. Results may lead to a gentler recovery for you.
Istanbul, BağcılarAges 18–50 - NCT07012278Recruiting
St. John's Wort oil for c-section recovery
This study tests if St. John's Wort oil helps heal the wound and reduce pain after a first cesarean section. If you've just had your first c-section and speak Turkish, this trial might be for you.
SakaryaAges 18–45 - NCT07004166Recruiting
New injection techniques to reduce pain and leakage
This study tests two different injection methods (TPR and Z-track) to see if they cause less pain and less medication leakage when giving the painkiller diclofenac sodium into the hip muscle.
SivasAges 18–40 - NCT07003802Enrolling by invitation
Understanding back muscle control in disc injury
This study looks at how the brain controls back muscles in people with chronic disc injuries. It compares patients before surgery or physical therapy to healthy controls to better understand muscle function.
La Jolla, CaliforniaAges 18–60 - NCT07008092Recruiting
Using PGE-M to predict appendicitis in children
This trial checks if a substance called PGE-M found in urine can help predict acute appendicitis in children with belly pain. If it works, it could help doctors diagnose appendicitis faster and without needing a blood test or CT scan.
SplitAges 5–17 - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06806514Recruiting
Exercise and muscle strength in chronic low back pain
This trial measures how well you can use your arms and how strong your breathing and other muscles are if you have chronic low back pain. It aims to understand the links between these factors to improve future treatments.
KırşehirAges 18–65 - NCT06908486Recruiting
Cognitive training for pain in type 2 diabetes
This study tests a computer-based training program that may help people with type 2 diabetes and ongoing pain think about pain in a less negative way. You can do it from home on your computer over 3 months.
Camperdown, New South WalesAges 18 years+ - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT06999460Recruiting
Shoulder block for pain relief during shoulder surgery
This trial tests if a nerve block near the shoulder blade can reduce pain before, during, and after shoulder surgery. It may help patients need less pain medicine and feel more comfortable.
Zagazig, EgyptAges 21–65 - NCT06995534Recruiting
Splint or Exercise for De Quervain's Wrist Pain
This trial compares wearing a splint versus doing specific exercises to treat De Quervain's tenosynovitis, a condition that causes wrist pain and swelling. It may help if you have new or worsening wrist pain without other injuries or diseases.
KonyaAges 18–65 - NCT07001566Recruiting
Neck nerve issues and shoulder function after rotator cuff repair
This study looks at how neck-related nerve problems (cervical radiculopathy) affect shoulder function in people who have had rotator cuff repair surgery. It aims to understand if neck issues can slow recovery or make it harder to use your arm normally.
Istanbul, IstanbulAges 41–65 - NCT06994507RecruitingPhase 3
GM1 to prevent nerve damage from breast cancer chemo
This trial tests whether a drug called GM1 can prevent nerve damage (numbness, tingling, or pain in hands/feet) caused by a common chemotherapy drug used for breast cancer. If you are starting chemotherapy with nab-paclitaxel, this study may help protect your nerves.
BeijingAges 18–75 - NCT06957912Recruiting
Ear nerve stimulation for recovery after major surgery
This trial tests if stimulating a nerve in your ear (vagus nerve) before and after noncardiac surgery can improve your recovery. It's for adults aged 18 to 84 having planned or time-sensitive surgery lasting at least 2 hours.
Beijing, Beijing MunicipalityAges 18–85 - NCT07002541Recruiting
Nerve block comparison for breast surgery pain
This study tests two different nerve-block methods (PECS-II and ESP) to see which better reduces painkiller use during breast surgery. A special monitor guides how much pain medicine you need. The goal is to help you recover with less opioid side effects.
IstanbulAges 18–80 - NCT06999395Recruiting
Virtual program for pelvic pain with vestibulodynia
This study tests whether a virtual program can help reduce pelvic pain and improve sexual experiences in people with a specific type of pain called provoked vestibulodynia. It is a completely online program, so you can participate from home.
Kingston, OntarioAges 18 years+ - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT06995937Recruiting
Medical marijuana and driving on a real road
This study looks at how medical marijuana affects driving ability in older adults with chronic pain. Participants will do a driving test on a real road to see if marijuana use changes driving performance.
Gainesville, FloridaAges 50 years+ - NCT06996379Recruiting
Testing J-Tip for pain relief during belly fluid drainage
This trial tests a device called J-Tip that numbs the skin before a paracentesis (a procedure to drain fluid from your belly). It's for adults with cirrhosis and ascites in the emergency department or hospital, and aims to make the procedure less painful.
Chicago, IllinoisAges 18 years+ - NCT07001709RecruitingPhase 4
How abiraterone affects oxycodone in prostate cancer
This study looks at how a common prostate cancer drug (abiraterone) affects how the body processes a painkiller (oxycodone). Men with prostate cancer who take abiraterone will be compared with those who do not, to see if the painkiller works differently.
Deventer, OverijsselAges 18 years+ - NCT06995352Enrolling by invitationPhase 4
Better pain relief after ankle surgery
This trial compares two methods of pain management after ankle surgery: a one-time injection of long-lasting numbing medicine (liposomal bupivacaine) versus a continuous nerve block via a small tube (catheter) placed near the nerve. The goal is to find which approach provides better pain relief with fewer side effects.
La Jolla, CaliforniaAges 18 years+ - NCT07001631Recruiting
EMDR for pain relief in children with sickle cell disease
This trial tests if EMDR therapy can help children with sickle cell disease reduce pain interference in daily life. If you or your child has sickle cell disease and experiences significant pain, this study may offer a new way to manage it.
AmsterdamAges 6–18 - NCT07002944Recruiting
Testing nerve treatment for shoulder pain after mastectomy
This study compares two types of pulsed radiofrequency (a minimally invasive treatment using radio waves) to see which better relieves shoulder pain in women who have had a mastectomy. It's for women who still have pain despite taking a high dose of tramadol.
CairoAges 18–65 - NCT07002853Recruiting
Nature walks for chronic back pain in older adults
This trial tests whether spending time in nature can help older adults with long-term low back pain feel better and move more easily. If you are 65 or older and have had back pain for at least three months, you may be able to join.
Saguenay, QuebecAges 65 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.