Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT07688902Recruiting
Comparing two injection methods for partial rotator cuff tears
This study compares two ways of injecting a sugar-water solution (5% dextrose) into the shoulder to treat partial rotator cuff tears. It may help reduce pain and improve shoulder function without surgery.
AnkaraAges 18–75 - NCT07683468Recruiting
A self-help kit for pain during sex with endometriosis
This trial tests if a special kit you can use at home helps reduce sexual pain caused by endometriosis. It might offer a new way to manage this common symptom.
StainsAges 18–45 - NCT04908579RecruitingPhase 4
Preventive ketamine to reduce pain after surgery
This study tests whether giving ketamine before or during surgery can reduce pain afterward. It is designed for adults with higher body weight who also have certain health conditions like well-controlled diabetes or blood pressure.
CairoAges 21–60 - NCT07682519Recruiting
Home vs. in-person rehab for hemophilia pain
This study compares a rehabilitation program you can do at home using video calls (telerehabilitation) with in-person rehabilitation sessions. The goal is to see if the home-based option works as well as office visits for reducing chronic joint pain in adults with hemophilia.
Santiago, Santiago MetropolitanAges 18–60 - NCT07685418Recruiting
Pressure therapy and home exercises for neck pain
This trial tests whether a hands-on technique called ischemic compression (applying gentle pressure to trigger points) plus home exercises helps relieve long-term neck pain that has no specific medical cause.
Istanbul, BakırköyAges 17–65 - NCT07683273Enrolling by invitation
Breathing exercises for neck and upper back pain
This study tests whether diaphragmatic breathing exercises can help reduce chronic, non-specific neck and upper back pain. If you have this type of pain that is not caused by an injury or disease, you may be able to join.
Trabzon, OrtahisarAges 18–60 - NCT07290517Recruiting
Using Carevix device for pain during IUD insertion
This trial tests if a special device called Carevix can make IUD insertion less painful. You may be able to join if you are scheduled to get an IUD placed and your provider plans to use the Carevix device.
Indianapolis, IndianaAges 18 years+ - NCT07291388Recruiting
Retrolaminar block for lumbar fusion with multimodal pain control
This study tests whether adding a retrolaminar block (a type of back injection) to standard pain medicines helps reduce pain after lumbar spine fusion surgery. It may help you recover with less need for strong painkillers.
Santiago, Santiago MetropolitanAges 18–75 - NCT07408193RecruitingEarly Phase 1
Lidocaine and ketamine for severe cancer pain not helped by opioids
This trial tests if adding lidocaine and ketamine to your current pain medicines can better control severe cancer-related pain that opioids alone haven't helped.
Athens, AtticaAges 18 years+ - NCT07661758RecruitingPhase 3
Lidocaine to prevent headache after C-section
This trial tests if giving lidocaine through an IV can prevent the headache that sometimes happens after spinal anesthesia during a planned C-section. If you are having a planned C-section with spinal anesthesia and meet other health requirements, this study might help reduce your risk of post-procedure headache.
Tanta, Gharbia GovernorateAges 18 years+ - NCT07247825Recruiting
Needle treatment for shoulder tendon pain: single vs multi-filament
This study tests two types of a needle-based treatment (percutaneous electrolysis) for shoulder tendon pain. It aims to see if a single-filament or multi-filament approach works better for people with chronic supraspinatus tendon issues.
SalamancaAges 18–65 - NCT07672015RecruitingPhase 4
Testing a new pain drug in surgery patients at risk for opioid dependence
This trial tests a new painkiller called suzetrigine for post-surgery pain. It's designed for people whose medical records suggest they may have a higher chance of needing strong painkillers (opioids) long after surgery. We want to see if suzetrigine works better at preventing that.
La Jolla, CaliforniaAges 18 years+ - NCT07504705Recruiting
Comparing two nerve blocks for pain after gallbladder surgery
This trial compares two types of nerve blocks (intertransverse process block and erector spinae plane block) to see which provides better pain relief after gallbladder removal surgery using small incisions (laparoscopic cholecystectomy).
Konya, KonyaAges 18 years+ - NCT07239258Recruiting
Tele-rehab plan for knee replacement recovery
This study tests a special therapy plan delivered through video calls to help people recover after knee replacement surgery. It compares telerehabilitation to in-person therapy to see if it improves pain and movement.
Lahore, Punjab ProvinceAges 50–65 - NCT07566871Enrolling by invitation
Nerve Stimulation to Help Burn Injury Recovery
This study tests whether gentle electrical stimulation of a nerve in your ear can help reduce anxiety, improve sleep, and ease pain or itching after a burn injury heals. You would wear a small device on your ear for several weeks.
Istanbul, KartalAges 18–65 - NCT07464860Recruiting
Breathwork for older adults after knee surgery
This study tests a breathing exercise program to help older adults recover after knee replacement surgery. Participants practice controlled breathing at home using a smartphone or computer.
Tucson, ArizonaAges 65 years+ - NCT07566923Enrolling by invitation
Vagus Nerve Stimulation for Teen Burn Recovery
This study tests a non-invasive device placed on the ear that stimulates the vagus nerve (a major nerve that affects stress and healing) to help adolescents recovering from burns feel less anxious, sleep better, and experience less pain and itching. The device is worn on the outside of the ear and may help your body heal.
Istanbul, KartalAges 12–18 - NCT07566910Enrolling by invitation
Vagus Nerve Stimulation to Reduce Pain During Burn Dressing Changes
This study tests a non-invasive device that stimulates a nerve in your ear to help reduce pain and stress during burn wound dressing changes. The device is applied to the outer ear and may help your body manage pain naturally without extra medication.
Istanbul, KartalAges 18–65 - NCT07428070Recruiting
Exercise program for rotator cuff shoulder pain
This trial tests if a specially designed exercise program can reduce shoulder pain related to the rotator cuff. It may help if you've had shoulder pain for more than three months.
IstanbulAges 18–75 - NCT07319273Recruiting
Child Life Services for Kids' Allergy Skin Tests
This study is testing whether a special program called 'Child Life Services' can help children feel more comfortable and less anxious during a skin prick test, which is a common allergy test. The goal is to make the experience easier for kids and their families.
ShanghaiAges 1–18 - NCT06707857Recruiting
TNT Treatment for Rotator Cuff Tendon Pain
This study tests if a treatment called TNT can reduce shoulder pain, improve movement, and help with daily activities in people with rotator cuff tendon problems. It may be a good option if you've had shoulder pain for at least three months.
Lahore, Punjab ProvinceAges 18–65 - NCT06708585Recruiting
Relaxation exercises for first-time mothers before c-section
This study tests whether providing information and teaching progressive muscle relaxation can help first-time mothers feel more relaxed and prepared before a planned cesarean section.
NiğdeAges 18–35 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.