Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06999395Recruiting
Virtual program for pelvic pain with vestibulodynia
This study tests whether a virtual program can help reduce pelvic pain and improve sexual experiences in people with a specific type of pain called provoked vestibulodynia. It is a completely online program, so you can participate from home.
Kingston, OntarioAges 18 years+ - NCT07000409Recruiting
Ultrasound-guided nerve block for shingles pain
This trial tests if a nerve block with betamethasone can reduce long-term shingles pain on the trunk. It may help people who still have pain more than 3 months after the rash appeared.
CairoAges 18–75 - NCT06996639Recruiting
Can eating before cardiac catheterization help? Study for heart patients
This study looks at whether it's safe to let patients eat a light meal before a scheduled heart catheterization, instead of fasting. It aims to improve comfort and experience for people with stable chest pain or certain types of heart attacks.
Tampa, FloridaAges 18 years+ - NCT06996574Recruiting
Comparing an all-in-one procedure with at-home screening for chronic pain
This trial tests if a single, all-in-one procedure works as well as the usual two-step process (screening at home first) for people with long-term nerve pain. It looks at how well pain is controlled and whether the simpler approach saves money.
AmsterdamAges 18 years+ - NCT06996379Recruiting
Testing J-Tip for pain relief during belly fluid drainage
This trial tests a device called J-Tip that numbs the skin before a paracentesis (a procedure to drain fluid from your belly). It's for adults with cirrhosis and ascites in the emergency department or hospital, and aims to make the procedure less painful.
Chicago, IllinoisAges 18 years+ - NCT07001631Recruiting
EMDR for pain relief in children with sickle cell disease
This trial tests if EMDR therapy can help children with sickle cell disease reduce pain interference in daily life. If you or your child has sickle cell disease and experiences significant pain, this study may offer a new way to manage it.
AmsterdamAges 6–18 - NCT07002944Recruiting
Testing nerve treatment for shoulder pain after mastectomy
This study compares two types of pulsed radiofrequency (a minimally invasive treatment using radio waves) to see which better relieves shoulder pain in women who have had a mastectomy. It's for women who still have pain despite taking a high dose of tramadol.
CairoAges 18–65 - NCT07002853Recruiting
Nature walks for chronic back pain in older adults
This trial tests whether spending time in nature can help older adults with long-term low back pain feel better and move more easily. If you are 65 or older and have had back pain for at least three months, you may be able to join.
Saguenay, QuebecAges 65 years+ - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT07001449Recruiting
Pain education for chronic muscle or joint pain
This study tests a type of pain education that focuses on communication to help people with long-term muscle or joint pain. It aims to see if learning about pain in a new way can help reduce symptoms and improve quality of life.
Lamia, Central GreeceAges 18–65 - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT06996561RecruitingPhase 2/Phase 3
How your genes affect pain relief after surgery
This study looks at how your genes might affect pain relief from a medication called nalbuphine after abdominal or pelvic surgery. It aims to personalize pain management based on your genetic makeup.
Karachi, SindhAges 18–70 - NCT06240260Recruiting
TENS unit for pain relief during IUD insertion
This study tests whether a small device called a TENS unit can reduce pain during IUD insertion. The TENS unit sends gentle electrical pulses through pads on your skin to help block pain signals, and you'll be part of a group that uses it during the procedure.
Boston, MassachusettsAges 12–50 - NCT06479122RecruitingPhase 4
Pain relief after C-section: acetaminophen with or without ibuprofen
This study compares two common pain relievers after C-section: acetaminophen alone versus acetaminophen plus ibuprofen. It aims to see if the combination offers better pain control after childbirth.
SeoulAges 19 years+ - NCT06932835Recruiting
Pain relief after gallbladder surgery: TAP vs. M-TAPA block
This trial compares two types of nerve blocks (TAP and M-TAPA) to see which one provides better pain relief after planned laparoscopic gallbladder removal. Both blocks are injections of numbing medicine around your abdomen to help control pain after surgery.
Yenimahalle, AnkaraAges 18–65 - NCT06989866Enrolling by invitationPhase 3
Testing if numbing injections reduce pain pill use after nose surgery
This trial tests whether a numbing injection (regional anesthesia) during nose surgery can reduce the need for strong pain pills afterward. It's for people having their first nose surgery at specific military hospitals.
Portsmouth, VirginiaAges 18 years+ - NCT06986668Enrolling by invitation
Warm wax and mud therapy for carpal tunnel syndrome
This trial tests if paraffin wax baths and peloidotherapy (mud therapy) help reduce symptoms of mild to moderate carpal tunnel syndrome (a hand nerve condition). It may be a good fit if you haven't had prior wrist surgery, steroid injections, or other nerve problems.
KonyaAges 18–65 - NCT00823563Recruiting
Testing heart artery causes of pain without major blockage
This study looks at people who are being checked for possible heart artery–related chest or similar discomfort, but without major artery blockage (non-obstructive arteries). It aims to help doctors understand what might be causing symptoms and guide safer testing.
Stanford, CaliforniaAges 18 years+ - NCT06992895Recruiting
Hologram for pain and fear during burn dressing changes in children
This trial tests whether watching a hologram during burn dressing changes can reduce pain, anxiety, and fear in children. It may help make the experience less stressful for kids aged 3 to 12 with small, second-degree burns.
Erzurum, YakutiyeAges 3–12 - NCT06987175Recruiting
Sedante Neo therapy for low back pain
This study tests a therapy called Sedante Neo to see if it reduces pain, improves movement, and boosts quality of life in people with common low back pain. It is designed for adults aged 20–40 whose back pain is mild to moderate and affects daily life.
Lahore, Punjab ProvinceAges 5 months–9 months - NCT06984939Recruiting
Handheld distraction tool for kids during needle procedures
This study tests a small handheld tool that may help distract children and teenagers during painful procedures like getting an IV, a blood draw, a dental needle, or if you have just been diagnosed with type 1 diabetes and need frequent blood checks and insulin shots. The tool is meant to make the experience less stressful.
Bergen, VestlandAges 8–15 - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT06985784Recruiting
Virtual reality for head and neck cancer patients and caregivers
This study tests whether using virtual reality can help reduce depression, anxiety, and pain in people with head and neck cancer and their caregivers. You and your caregiver may be able to use VR headsets together as part of your treatment.
Duarte, CaliforniaAges 18 years+ - NCT06991387Recruiting
Myofascial release for text neck pain
This study tests a hands-on therapy called myofascial release to see if it can quickly ease neck pain and related symptoms from 'text neck' (pain from using devices too much). If you are a young adult who spends a lot of time on your phone and has neck pain, you might be a good fit.
Karabük, Karabük ProvinceAges 18–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.