Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07023497Recruiting
Finding the best dose of spinal morphine for C-section pain relief
This study tests different doses of morphine given through a spinal injection during a planned C-section to find the best balance of pain relief and side effects. It may help women have better pain control after surgery.
Ioannina, EpirusAges 18–50 - NCT07016672Recruiting
PRP vs. hyaluronic acid for advanced knee arthritis
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Toulon, VarAges 18 years+ - NCT07023185Recruiting
Cold and compression after knee replacement
This study will test if adding cold and compression therapy after knee replacement surgery can help with pain, swelling, and recovery. You may qualify if you are 50 or older and having a knee replacement with a specific surgeon.
New Orleans, LouisianaAges 50 years+ - NCT07016971RecruitingPhase 1
CBG/CBD oil for nerve pain from chemotherapy
This trial tests whether a blend of CBG and CBD oils can help relieve nerve pain, tingling, or weakness caused by platinum-based chemotherapy in people with certain gastrointestinal cancers. If you have had colorectal, biliary, pancreatic, esophageal, gastric, or small intestinal cancer and completed chemo in the last 2 years, you may be able to join.
Hershey, PennsylvaniaAges 21 years+ - NCT06332495Recruiting
Bedpan comfort study for bedridden patients
This study looks at how comfortable and safe bedpans are for patients and caregivers. It aims to find ways to reduce pain and skin irritation for people who are bedridden.
Nantes, Loire AtlantiqueAges 18 years+ - NCT07008703RecruitingPhase 1/Phase 2
Study of sss40 for cancer bone pain
This trial tests a new injection called sss40 to treat moderate-to-severe pain caused by cancer that has spread to the bones. The goal is to see if it is safe and effective for people whose pain is not being controlled by current treatments.
Zhengzhou, HenanAges 18 years+ - NCT07011537Enrolling by invitation
Digital health program and TENS for chronic low back pain
This trial tests a digital health program combined with a TENS device (a small device that sends gentle electrical pulses to help with pain) for people with ongoing low back pain. It compares this approach to standard care, and you would be randomly assigned to one of the two groups.
Eden Prairie, MinnesotaAges 18 years+ - NCT07006389Enrolling by invitation
Shock wave therapy for plantar fasciitis follow-up study
This study looks at how well shock wave therapy works for people with plantar fasciitis that hasn't improved with other treatments. If you've already had shock wave therapy 3 to 6 months ago, your experience could help doctors understand what makes the treatment effective.
IstanbulAges 18 years+ - NCT07004699Recruiting
Comparing two breathing methods during throat and esophagus exams
This study compares two ways of helping you breathe while you are sedated for an endoscopy of your throat, voice box, and esophagus. It aims to find which method is safer and more comfortable for patients like you.
La Roche-sur-YonAges 18 years+ - NCT07010029Recruiting
Heart vein device for angina with no blocked arteries
This trial tests a special device placed in a vein of the heart to help patients who have chest pain (angina) but no major blockages in their heart arteries. It is designed for people who have tried maximum medications but still have symptoms.
WarsawAges 18 years+ - NCT07013344Recruiting
Link between NT-proBNP and heart artery disease
This study looks at a blood test called NT-proBNP to see if it can help predict how much blockage is in the heart's arteries. It may help doctors better understand heart disease risk.
Milan, ItalyAges 18 years+ - NCT07009951Recruiting
Virtual reality during heart device implant
This trial tests if using a virtual reality (VR) headset during pacemaker or defibrillator implant surgery can help reduce pain and anxiety. It may offer a drug-free way to help you feel more comfortable during the procedure.
CosenzaAges 18 years+ - NCT07011875Enrolling by invitation
Physical activity and period pain in women with MS
This study looks at how physical activity levels affect period pain, menstrual symptoms, and emotional well-being in women with multiple sclerosis. It aims to find out if being more active can help with these issues.
Karabük, Karabük ProvinceAges 18–55 - NCT07003802Enrolling by invitation
Understanding back muscle control in disc injury
This study looks at how the brain controls back muscles in people with chronic disc injuries. It compares patients before surgery or physical therapy to healthy controls to better understand muscle function.
La Jolla, CaliforniaAges 18–60 - NCT07008092Recruiting
Using PGE-M to predict appendicitis in children
This trial checks if a substance called PGE-M found in urine can help predict acute appendicitis in children with belly pain. If it works, it could help doctors diagnose appendicitis faster and without needing a blood test or CT scan.
SplitAges 5–17 - NCT07004166Recruiting
New injection techniques to reduce pain and leakage
This study tests two different injection methods (TPR and Z-track) to see if they cause less pain and less medication leakage when giving the painkiller diclofenac sodium into the hip muscle.
SivasAges 18–40 - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Indianapolis, IndianaAges 18–80 - NCT07005375Enrolling by invitation
Hot mineral water baths for rowers' pain and performance
This trial tests whether bathing in thermal mineral water can reduce pain and improve performance in rowers. It is open to competitive and recreational rowers who train regularly.
Budapest, BudapestAges 14–75 - NCT07004634Recruiting
Comparing Drain Types After Minimally Invasive Esophageal Cancer Surgery
This study compares two different ways of placing drains after minimally invasive surgery for esophageal cancer. It aims to find which method helps you recover better and with fewer complications.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07006610Recruiting
Tape or cooling therapy for jaw surgery recovery
This study tests whether cooling with a hilotherapy device or taping with kinesio tape helps reduce swelling and pain after double-jaw surgery. Results may lead to a gentler recovery for you.
Istanbul, BağcılarAges 18–50 - NCT07009028Recruiting
Storigami to reduce pain and fear from IV insertion in kids
This study tests a fun storytelling-and-paper-folding method called 'storigami' to see if it helps children feel less pain, fear, and worry when they get an IV. It's for children who need an IV for the first time during this hospital visit.
Izmir, BornovaAges 6–9 - NCT07010003Recruiting
Ear acupressure for anxiety and pain during heart surgery
This trial tests whether small ear acupressure beads can help reduce anxiety and pain in adults having planned heart surgery. The beads are placed on specific ear points and are easy to use.
StuttgartAges 18 years+ - NCT07012278Recruiting
St. John's Wort oil for c-section recovery
This study tests if St. John's Wort oil helps heal the wound and reduce pain after a first cesarean section. If you've just had your first c-section and speak Turkish, this trial might be for you.
SakaryaAges 18–45
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.