Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06984939Recruiting
Handheld distraction tool for kids during needle procedures
This study tests a small handheld tool that may help distract children and teenagers during painful procedures like getting an IV, a blood draw, a dental needle, or if you have just been diagnosed with type 1 diabetes and need frequent blood checks and insulin shots. The tool is meant to make the experience less stressful.
Bergen, VestlandAges 8–15 - NCT06984354Recruiting
Digital treatments for chronic low back pain
This trial tests a smartphone app to help people with long-term low back pain. It aims to see if digital treatments can reduce pain and improve daily function.
Randwick, New South WalesAges 18 years+ - NCT06988930Enrolling by invitation
Comparing two treatments for lateral patellar crush syndrome
This trial compares two treatments for lateral patellar crush syndrome: a type of knee surgery called lateral retinacular release versus specific exercises. The goal is to see which approach works better for reducing pain and improving function.
BeijingAges Any age - NCT06984796Enrolling by invitation
Light therapy for pain during IUD insertion
This study tests if light therapy (photobiomodulation) can reduce pain when an IUD is inserted. It might help women who are anxious about pain during the procedure.
São PauloAges 18–50 - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT06991387Recruiting
Myofascial release for text neck pain
This study tests a hands-on therapy called myofascial release to see if it can quickly ease neck pain and related symptoms from 'text neck' (pain from using devices too much). If you are a young adult who spends a lot of time on your phone and has neck pain, you might be a good fit.
Karabük, Karabük ProvinceAges 18–40 - NCT06987565RecruitingPhase 2
Nerve stimulation device for lupus pain
This trial tests whether a non-invasive nerve stimulation device worn on the ear can help reduce pain and inflammation in people with lupus. It may be an option if you have moderate to severe muscle or joint pain and are not on certain medications that were recently started.
Manhasset, New YorkAges 18 years+ - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06987175Recruiting
Sedante Neo therapy for low back pain
This study tests a therapy called Sedante Neo to see if it reduces pain, improves movement, and boosts quality of life in people with common low back pain. It is designed for adults aged 20–40 whose back pain is mild to moderate and affects daily life.
Lahore, Punjab ProvinceAges 5 months–9 months - NCT06985784Recruiting
Virtual reality for head and neck cancer patients and caregivers
This study tests whether using virtual reality can help reduce depression, anxiety, and pain in people with head and neck cancer and their caregivers. You and your caregiver may be able to use VR headsets together as part of your treatment.
Duarte, CaliforniaAges 18 years+ - NCT06657326Recruiting
New stent for high bleeding risk patients
This trial tests a new type of stent (BioFreedom Ultra) compared to a standard one (BioFreedom) in people who have a high risk of bleeding. Both stents release medicine to keep arteries open, and the study checks if the newer stent works better with a shorter course of blood thinners.
Johor Bahru, JohorAges 18 years+ - NCT04988724Recruiting
Hospital staff exercise program trial
This trial tests whether a hospital-based exercise program is feasible and beneficial for hospital employees at Nordsjællands Hospital. It may help staff feel better and potentially improve wellbeing at work.
Hillerød, Capital RegionAges 18 years+ - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT06977321Recruiting
Taping vs mud therapy for carpal tunnel syndrome
This study tests whether taping therapy (kinesiotaping) or a mud pack treatment (peloidotherapy) can help reduce pain and improve function for people with mild to moderate carpal tunnel syndrome. It may be an option if you want non-surgical, drug-free relief.
KonyaAges 1.5 years–5.4 years - NCT06974773Recruiting
Electrical stimulation for endometriosis pain flare-ups
This trial tests a remote electrical stimulation device to reduce endometriosis pain flare-ups. It may help if you have regular or irregular periods with pelvic pain and own a smartphone.
San Francisco, CaliforniaAges 22–45 - NCT06400290Recruiting
Balloon test to find which artery causes chest pain
This study tests a new way to find which blocked heart arteries are causing your chest pain. During a stent procedure, doctors will briefly block each artery to see which one triggers your symptoms. This might help them decide which blockages to treat.
BasildonAges 18 years+ - NCT06976320Recruiting
Nerve block for gallbladder surgery pain
This trial tests a nerve block injection in the abdominal wall to reduce pain after gallbladder removal surgery. It may help patients recover more comfortably.
IstanbulAges 18–80 - NCT06976632Recruiting
Helping ease vaccine pain for pregnant women
This study tests two simple methods (a skin tap and a cold spray) to see if they can reduce pain and stress during a tetanus vaccine shot in pregnant women.
Manisa, Uncubozköy/YunusemreAges 18–42 - NCT06977919Enrolling by invitation
New exercise method for chest firmness and shape
This trial tests a new technique (called NASM OPT) to help improve the shape and firmness of your chest. It is for women who have not been exercising and who want to enhance their chest appearance without using surgery.
Zahedan, Sistan and BaluchestanAges 20–45 - NCT06979583Enrolling by invitation
Stent and sheath size and pain after kidney stone surgery
This study compares whether the size of the stent and the sheath used during kidney stone surgery affects how much pain you feel afterward. If you are having a stone removal procedure and will get a stent with a string, you may be able to join.
Rochester, MinnesotaAges 18 years+ - NCT06973746Recruiting
Sitting up in a chair in the ICU for patients on breathing machines
This study tests whether getting patients who are on a breathing machine to sit in a chair helps them recover better. It looks at whether this simple activity can improve how well they get back to normal function.
Orléans, Centre-Val de LoireAges 18 years+ - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT06978127Recruiting
Tech help for dialysis patients to feel better
This study tests a program that uses technology to help people on dialysis feel better and take a more active role in their care. It may help you if you are on dialysis and want extra support.
Albuquerque, New MexicoAges 18 years+ - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.