Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06713044Recruiting
Quran recitation or music for pain after leg surgery
This trial tests whether listening to Quranic recitation or classical music can reduce pain and inflammation after lower-leg orthopedic surgery. It may help Muslim patients manage pain without extra medication.
Purwokerto, Central JavaAges 18–60 - NCT06715761Recruiting
Myofascial release for chronic low back pain in CrossFit athletes
This trial tests if a hands-on or tool-assisted muscle release technique can reduce long-term low back pain and improve posture in people who do CrossFit. If you have had low back pain for at least 12 weeks and do CrossFit regularly, this study may help you find relief.
Goiânia, GoiásAges 18–59 - NCT06716489Recruiting
Exercise study for women with migraine
This study tests whether aerobic exercise can help reduce migraine symptoms and improve how your body senses and responds to pain. It is specifically for women aged 18–48 who have migraine headaches 3–8 days per month.
Ribeirão Preto, São PauloAges 18–48 - NCT06718296Recruiting
Photographic Shoulder Pain Scale Study
This study is creating a new way to measure shoulder pain using pictures. It is for people who have had shoulder pain for more than 3 months, whether from an injury or other causes.
IstanbulAges 18–64 - NCT06718374Recruiting
Chest pain differences in diabetic vs non-diabetic patients
This study compares how chest pain feels in people with and without diabetes after a heart attack. It aims to understand if diabetes changes the symptoms, which could help doctors diagnose faster.
Asyut, Asyut GovernorateAges Any age - NCT06718348Recruiting
Lumbar Traction Device for Low Back Pain
This trial tests a supportive device (Japet.W+) that gently pulls on your lower back to help reduce pain. If you have had low back pain for more than 6 weeks without a specific cause, you may join.
Charleroi, HainautAges 18 years+ - NCT06719245Recruiting
Preventing post-amputation pain with targeted nerve surgery
This trial tests a surgical procedure called targeted muscle reinnervation (TMR) to prevent pain after a leg amputation. The goal is to see if rerouting nerves during amputation can reduce phantom limb pain or stump pain.
Amsterdam, North HollandAges 18–75 - NCT06721962RecruitingPhase 1/Phase 2
Testing an experimental treatment for moderate to severe Crohn's disease
This trial is testing a new investigational treatment called TRX103 for adults with moderate to severe Crohn's disease that has not responded to at least two other advanced therapies. The study aims to see if this treatment can reduce inflammation and improve symptoms.
Scottsdale, ArizonaAges 18–65 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06726239Recruiting
Relaxation exercises before getting up after heart bypass
This study tests whether doing gentle relaxation exercises before getting out of bed can help reduce pain, anxiety, and stress after heart bypass surgery. It may make recovery more comfortable.
Istanbul, IstanbulAges 35–65 - NCT06725862Recruiting
Pain relief methods for undescended testis surgery in children
This study compares two different numbing injections (caudal block vs retrolaminar block) given before surgery to see which one provides better pain control for children aged 1-7 undergoing undescended testis surgery.
IstanbulAges 1–7 - NCT06726954Recruiting
Magnetic brain stimulation for spinal cord injury pain
This study tests whether a magnetic treatment called repetitive transcranial magnetic stimulation (rTMS) can help reduce nerve pain that some people have after a spinal cord injury. rTMS uses painless magnetic pulses to gently stimulate the brain, and it may help change how your brain processes pain.
AfyonkarahisarAges 18–75 - NCT06728371RecruitingPhase 3
IV methadone for pain after heart surgery
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
Hong KongAges 18 years+ - NCT06728579RecruitingPhase 2
Group therapy for joint pain in breast cancer survivors
This study tests two supportive group programs—one using mindfulness skills, the other providing supportive talk therapy—to help breast cancer survivors manage joint pain caused by hormone-blocking pills. If you have ongoing joint pain and are taking an aromatase inhibitor, you may be able to join a free, video-based group.
San Diego, CaliforniaAges 18 years+ - NCT06729294Recruiting
Does music help during knee replacement surgery?
This study tests if listening to music during knee replacement surgery under spinal anesthesia can lower anxiety, pain, and stress hormone levels. It may help make the experience calmer for patients.
Kocasinan, KayseriAges 18 years+ - NCT06731335RecruitingPhase 2
Psilocybin for chronic nerve pain that hasn't improved with other treatments
This study tests whether psilocybin (a compound found in certain mushrooms) can help reduce chronic nerve pain that has not responded well to standard medications. You will receive study treatment plus psychotherapy to see if it improves your pain.
Toronto, OntarioAges 18–65 - NCT06731920Recruiting
Ultrasound guided neck injection study
This study is testing a new way to guide a neck injection (called a cervical medial branch block) using ultrasound. It may help doctors do the procedure more safely and accurately.
Kelowna, British ColumbiaAges 19 years+ - NCT06731985Recruiting
Shorter sling tape follow-up study
This study looks at how well and how safely a shorter type of sling tape (used to treat stress urinary incontinence) works over time. It may help women who had this specific surgery between 2009 and 2020 understand their long-term results.
LorenskogAges 25–90 - NCT06736483RecruitingPhase 2
Dexmedetomidine for children’s groin surgery recovery
This trial tests whether adding a sedative called dexmedetomidine to a numbing shot (nerve block) helps children aged 1–7 recover better after groin surgery. The goal is to improve comfort and reduce side effects.
Montpellier, FranceAges 1–7 - NCT06736795Recruiting
Online support for Achilles tendon loading exercises
This study tests whether extra support from a clinician during a progressive exercise program helps people with Achilles tendon pain improve faster. You'll do exercises that gradually increase the load on your tendon, with guidance from a physical therapist via video visits.
Iowa City, IowaAges 18–60 - NCT06737900Recruiting
Jandas vs PNF for pain and mobility in lower back pain
This study compares two physical therapy methods—Jandas Approach and PNF (Proprioceptive Neuromuscular Facilitation)—to see which works better for reducing lower back pain, improving movement, and making daily activities easier. It is for adults with ongoing back pain and specific muscle tightness or weakness.
Lahore, Punjab ProvinceAges 25–40 - NCT06740214RecruitingPhase 3
Different doses of liposomal bupivacaine for knee replacement pain
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
Hong Kong, Hong KongAges 18–80 - NCT06740903RecruitingPhase 2/Phase 3
Comparing two drugs for pain control in gallbladder surgery
This study compares two medications, dexmedetomidine and lignocaine, to see which works better for pain management during and after laparoscopic gallbladder removal. It may help improve comfort and recovery for people having this surgery.
Sahiwal, Punjab ProvinceAges 20–70 - NCT06741059Recruiting
TENS for period pain relief
This study tests if TENS, a gentle electrical stimulation device, can reduce period pain and related symptoms. If you have painful periods and are not using other treatments, this might be an option for you.
OsmaniyeAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.