Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06906211Recruiting
Ultrasound for chronic back pain in veterans
This trial tests if a gentle ultrasound treatment to a specific part of the brain can help veterans with chronic back pain. It aims to see if targeting the insula can reduce pain that spreads to other areas of the body.
Washington D.C., District of ColumbiaAges 21–75 - NCT06911437Enrolling by invitation
Knee pain relief with Chinese formula and massage
This study tests if combining a Chinese herbal formula called Xiaoyu Zhitong with a gentle drainage massage can reduce knee pain and swelling. It may help people whose knee symptoms are worse in cold, damp weather.
BeijingAges 25–70 - NCT06910696Enrolling by invitation
Comparing two nerve blocks for lumbar disc surgery pain
This trial tests two types of nerve blocks to see which one works better for pain control after lumbar disc surgery. It may help reduce pain and the need for strong pain medicines after your operation.
ZagazigAges 21–64 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06894355Recruiting
Hydrotherapy for athletes with long-term back pain
This trial tests whether group hydrotherapy (water-based exercise) can help athletes with long-term low back pain. It may be a good fit if you are an active athlete, have had back pain for at least 3 months, and train frequently.
NetanyaAges 18 years+ - NCT06910150Enrolling by invitation
Pain relief after knee surgery: electric stimulation study
This trial tests two types of mild electric stimulation (one with tiny needles, one without) applied to the thigh muscle to reduce pain in people who had ACL knee surgery in the last six weeks. The goal is to see if this can help you feel better and recover quicker.
Madrid, MadridAges 18–55 - NCT06902636Recruiting
Trauma care program for older adults living alone
This trial tests a special care program for older adults who live alone and have limb injuries. It aims to help them recover safely at home using smartphone support for three months.
Kaohsiung City, KaohsiungAges 65 years+ - NCT06910982Enrolling by invitation
Yoga and Mindfulness for Chronic Low Back Pain
This study tests whether a combination of yoga and mindfulness exercises can help reduce chronic lower back pain. It compares this program to usual care, and may be a good fit if your pain is bothersome but you are not too afraid that moving will make it worse.
Karachi, SindhAges 25–45 - NCT06903975RecruitingPhase 4
Botox for a more feminine neck appearance
This trial tests Botox injections into the neck muscles to create a more feminine neck contour. It may be an option if you're looking for a non-surgical way to soften or slim the look of your neck.
Newton, MassachusettsAges 18–65 - NCT06903962Recruiting
Mind-body program for chronic arm or hand pain
This trial tests whether a mind-body program can help people with long-term pain in their upper arm, forearm, or hand that is not caused by a clear physical injury. It focuses on retraining how your brain responds to pain triggers.
Boston, MassachusettsAges 18–60 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06902233Recruiting
Brain stimulation for chronic low back pain
This trial tests if a non-invasive brain stimulation technique can help people with long-lasting low back pain. It uses mild electrical currents to adjust brain activity and may reduce pain and improve daily function.
Dunedin, OtagoAges 18–75 - NCT04242589RecruitingPhase 2
Radiation plus bone cement for painful spinal metastasis pain
This trial tests adding a bone-cement procedure (vertebroplasty) along with radiation to reduce pain from cancer that has spread to the spine. It is for adults with painful metastatic (spread) tumors in the middle or lower spine, without current spinal cord pressure.
Edmonton, AlbertaAges 18 years+ - NCT04832100Recruiting
Study of a fat marker in fibromyalgia
This study looks at whether a specific fat-related marker (called LPC16:0) is linked to fibromyalgia. Your participation could help researchers understand what role this marker may play in the condition.
Kaohsiung CityAges 18–70 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06308029Recruiting
E-health pain self-management for breast cancer survivors
This trial tests an online program to help people manage lasting pain after breast cancer treatment. It's designed for those whose pain still gets in the way of daily life, even after finishing primary treatment.
AntwerpAges 18 years+ - NCT06418217Recruiting
Exercise and education for lateral hip pain
This study tests whether exercise and patient education can help people with long-term lateral hip pain (pain on the outside of the hip). If you've had hip pain for over 6 months and an MRI confirms the cause, you may be able to join.
Horsens, HorsensAges 18–75 - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT06569953RecruitingPhase 4
Numbing Medicine for Pain After Lung Surgery
This study tests whether a long-lasting numbing medicine (liposomal bupivacaine) injected near the spine can better control pain after lung surgery. It compares this to a standard numbing medicine, and aims to help patients recover with less pain after surgery.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06892496Recruiting
Healing after palate graft: comparing protection methods
This trial compares different ways to protect the roof of your mouth after a small tissue graft is taken to cover exposed roots or gum recession. It aims to find which method reduces pain and helps healing.
Richmond, VirginiaAges 18 years+ - NCT06892977Enrolling by invitation
Stress and pain interaction study
This study looks at how stress affects pain sensitivity and how the brain processes pain. It uses MRI scans to see brain activity while participants experience mild pain, which may help improve pain treatments.
GhentAges 18–55 - NCT06895564Recruiting
Proton radiation for hard-to-treat spine tumors
This trial tests a special type of proton radiation for people whose spine cancer has spread from another part of the body and cannot be treated effectively with standard X-ray radiation. The goal is to see if proton radiation can safely deliver a high dose of radiation to the tumor.
Baltimore, MarylandAges 18 years+ - NCT06892743Recruiting
Comparing two pain blocks for kidney removal surgery
This trial compares two ultrasound-guided nerve blocks to see which one provides better pain relief for patients undergoing open kidney removal (nephrectomy). If you have kidney cancer and are scheduled for this surgery, you may be able to join.
Maadi, Cairo GovernorateAges 18–70 - NCT06891625Recruiting
Movement performance in people with chronic back pain
This study looks at how people with long-term back pain move. It aims to understand movement patterns in chronic back pain, which could help design better treatments.
HuddingeAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.