Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06835868Recruiting
Registry for nerve stimulation treatments for chronic pain in Belgium
This trial creates a registry for people with chronic pain who are getting special nerve-modulating treatments in Belgium. It focuses on two specific chronic pain conditions: Persistent Spinal Pain Syndrome Type 2 (pain after spine surgery) and Complex Regional Pain Syndrome (a type of nerve pain).
Edegem, AntwerpAges Any age - NCT06837857RecruitingPhase 2
Opioid pain relief study for older adults with chronic pain
This study tests whether a carefully managed prescription opioid can safely help older adults with long-term pain that hasn't been relieved by other pain medicines. The goal is to see if it improves pain without harming memory or brain health.
Rochester, MinnesotaAges 65 years+ - NCT06837909Recruiting
Nerve block vs wound injection for breathing after kidney donation
This study compares two ways to manage pain after laparoscopic kidney donation surgery: a nerve block (injection near the belly muscles) versus injecting numbing medicine directly into the surgical wound. The goal is to see which method helps you breathe better after surgery.
Petah TikvaAges 18 years+ - NCT06838039Recruiting
A second nerve block for less pain after lung surgery
This study tests whether adding a second nerve block (serratus anterior block) within 24 hours after a lung surgery (VATS) can reduce pain better than the standard nerve block alone. It aims to help patients control pain with fewer strong painkillers.
HebronAges 18–70 - NCT06838572Recruiting
Cooling the wrist to reduce pain from arterial line placement
This study tests whether cooling the skin on your wrist before a routine arterial line placement (a small tube in your wrist artery) can reduce the pain of the procedure. If you are having surgery and need an arterial line, this might help make the experience more comfortable.
Chongqing, Chongqing MunicipalityAges Any age - NCT06840314Recruiting
Vibration vs traditional therapy for painful sex
This trial compares a vibrating vaginal device to standard therapy for women with pain during sex. It aims to find a more effective and comfortable treatment option.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06841276Recruiting
Digital tool for chronic pain relief study
This study tests a smartphone device called QoLibri that helps manage long-term pain. You use it at home for a few weeks to see if it reduces pain and improves daily life.
NaillouxAges 18 years+ - NCT06842329Recruiting
Can distraction ease injection pain for teens with period pain?
This study tests whether using simple distraction techniques during a shot can reduce pain in teenage girls who come to the emergency room with severe menstrual cramps.
SamsunAges 12–18 - NCT06844838Recruiting
Faster, Safer Awakening After Brain Surgery
This study tests a new way of giving anesthesia during elective brain surgery to help you wake up faster and safer. It uses a special monitor to guide the amount of medication so you can recover more quickly.
MilanAges 18 years+ - NCT06844552Recruiting
Diamagnetic therapy for pain and inflammation
This trial tests a new magnetic therapy to reduce pain and inflammation in conditions like arthritis or injuries. It may help if standard medications have not worked well enough for you.
Catanzaro, ItaliaAges 18–75 - NCT06845215Recruiting
Pain block comparison for abdominoplasty recovery
This trial compares two types of nerve blocks (TAP and ESP) to see which provides better pain relief after tummy tuck surgery. Both are injections near the abdominal muscles that numb the area, and you'll also have a patient-controlled pain pump.
Ankara, KeçiörenAges Any age - NCT06845631Recruiting
Study of Freedom PNS for chronic pain
This study looks at how well the Freedom PNS system works for people who already have it implanted. It helps doctors learn more about treating chronic pain with this device.
Cleveland, OhioAges 18 years+ - NCT06847360Recruiting
Home-based ear stimulation for IBS pain
This trial tests a gentle, non-invasive ear stimulation device (taVNS) used at home to reduce pain from Irritable Bowel Syndrome (IBS). It might help if you have moderate pain most days.
New Haven, ConnecticutAges 18–29 - NCT06847763Recruiting
Online pain education for chronic low back pain
This study tests an online class that teaches you about how your brain and nerves process pain, to help you manage chronic low back pain. It is a long-term program you can join from home.
Istanbul, AtasehirAges 20–60 - NCT06848218Recruiting
Music therapy during non-invasive breathing support for children
This study tests if music therapy can help children who are receiving breathing support (non-invasive ventilation) in the pediatric intensive care unit. It aims to reduce stress and discomfort during treatment.
MontpellierAges Up to 17 years - NCT06848348RecruitingPhase 2
Halneuron for chemotherapy-induced nerve pain
This trial tests whether the drug Halneuron can safely reduce nerve pain caused by common chemotherapy drugs (platinum and taxane). It is for people whose nerve pain started after chemotherapy and whose cancer is not currently getting worse.
Sheffield, AlabamaAges 18 years+ - NCT06854718Recruiting
Pain Management Study for People with Dementia
This study tests a new approach to help people with dementia who have chronic pain. It looks at how caregivers can support pain management at home.
Durham, North CarolinaAges 50 years+ - NCT06854809Recruiting
Cognitive therapy vs. exercises for chronic shoulder pain
This study compares two non-surgical treatments for long-lasting shoulder pain: a new approach called cognitive functional therapy that combines movement with education, versus standard exercises. If you have chronic shoulder pain and are looking for a drug-free option, this trial may help you find which treatment works better.
São Carlos, São PauloAges 18–65 - NCT06856642Recruiting
Comparing belly drawing exercises with ultrasound for chronic back pain
This study compares two types of physical therapy for chronic low back pain: one uses real-time ultrasound to help you learn a special belly-drawing maneuver, the other is standard physical therapy. The goal is to see which method reduces pain better.
BoluAges 18–65 - NCT06856538Recruiting
Comparing two nerve blocks for pain after chest surgery
This trial tests two types of nerve blocks (RISS and SAP blocks) to see which one works better for pain control during and after a thoracotomy (chest surgery). If you are having a chest surgery that involves only one side of your chest, this trial could help find a more comfortable recovery.
El Fayoum Qesm, Faiyum GovernorateAges 18–70 - NCT06856733Recruiting
Better opioid management for long-term non-cancer pain
This study tests a new way to help people who have been taking opioids for chronic pain (not caused by cancer) for at least 90 days. The goal is to improve treatment and reduce risks, such as developing tolerance or side effects, while still managing pain effectively.
Strängnäs, SörmlandAges 18–70 - NCT06857838Recruiting
Bypass surgery for symptomatic myocardial bridge
This trial tests whether bypass surgery is effective for people with a myocardial bridge (a heart muscle that arches over an artery) that still causes symptoms despite medication. It aims to see if surgery can improve symptoms and outcomes.
Xi'an, ShaanxiAges 18–80 - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT06859710RecruitingPhase 1
THC and CBD as a harm reduction strategy
This study looks at whether different types of cannabis (containing THC and/or CBD) might help people who use cannabis regularly reduce potential harms. You will be asked to take cannabis in a controlled setting and complete tasks and questionnaires.
Los Angeles, CaliforniaAges 21–55
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.