Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06628180Enrolling by invitation
Low-intensity focused ultrasound for chronic pain
This study tests a noninvasive treatment called low-intensity focused ultrasound (LIFU) to help relieve chronic pain. It may be an option if you have had moderate to severe pain for at least 3 months.
Roanoke, VirginiaAges 18–65 - NCT06626035RecruitingPhase 3
Pain Medicine Study for Children Having Heart Surgery
This study tests a pain medicine for children having heart surgery. It aims to see if the medicine works well and is safe for managing pain after the operation.
Oakland, CaliforniaAges 3–18 - NCT06628921Recruiting
Eptinezumab for treating a migraine attack right now
This trial tests if eptinezumab can stop a migraine attack that is already happening. It may help people who get migraines often and are already part of the TACHIS study.
RomaAges 18 years+ - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT06620133Recruiting
Pain education and goal setting for chronic low back pain
This trial tests whether learning about pain and setting your own exercise goals helps people with long-term low back pain become more active. You will receive online sessions and support to safely increase your physical activity.
Sydney, New South WalesAges 18 years+ - NCT06619418Recruiting
Home Device Using Sound and Body Stimulation for Back Pain
This study is testing a take-home device that uses sound and gentle body stimulation to help with long-term back pain. It is for adults with chronic low back pain who live near the University of Minnesota and are not taking certain sleep or anxiety medications.
Minneapolis, MinnesotaAges 18 years+ - NCT06620471Recruiting
Better nerve blocks with impedance testing
This study looks at whether adding impedance testing to ultrasound guidance improves accuracy for arm and leg nerve blocks. If you need a nerve block for surgery, this may help us learn how to make them safer and more effective.
Beirut, BeirutAges 18–90 - NCT06621329RecruitingPhase 2/Phase 3
Numbing shot for headache after brain bleed
This trial tests a numbing injection inside the nose to quickly relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). It may help reduce pain without strong medicines.
Sacramento, CaliforniaAges 18–100 - NCT06628908RecruitingPhase 3
Study of suzetrigine for painful diabetic nerve damage
This trial tests an experimental medicine called suzetrigine to see if it can safely reduce pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It might be an option if you have had daily pain in both legs and current treatments haven't worked well enough.
Anniston, AlabamaAges 18–80 - NCT06619860RecruitingPhase 2
VX-993 for diabetic nerve pain
This trial tests a new medicine called VX-993 for people with diabetes who have had nerve pain in both feet or legs for at least a year. The goal is to see if it reduces pain and is safe.
Cullman, AlabamaAges 18–80 - NCT06602271RecruitingPhase 3
Study of PF614 for Pain After Tummy Tuck Surgery
This study tests a new painkiller called PF614 for pain after tummy tuck surgery. It compares the study drug to a placebo (a pill with no medicine) to see how well it works and how safe it is.
Atlanta, GeorgiaAges 18–75 - NCT05540548Recruiting
Podiatry assessment for balance and pain in chronic back pain
This study looks at whether a foot and posture specialist can help measure how balance relates to the pain you feel in chronic low back pain. It may help doctors better understand what to focus on for pain that lasts for months.
ValenciennesAges 18 years+ - NCT06616324Recruiting
Virtual reality to reduce pain during kidney stone treatment
This study tests whether using a virtual reality (VR) headset during a kidney stone treatment called ESWL can help reduce pain and anxiety. If you're scheduled for ESWL at a hospital in Region Zealand, you may be able to use VR to distract yourself during the procedure.
RoskildeAges 18 years+ - NCT06600919Recruiting
Music therapy app for anxiety before ENT surgery
This study tests whether listening to calming music through a phone app before ENT surgery can help prevent anxiety. It is for adults who are scheduled for ear, nose, or throat surgery.
Saint-DenisAges 18 years+ - NCT06603051Recruiting
Freezing a nerve before ACL surgery to cut opioid use
This study looks at freezing a nerve before ACL surgery to help reduce the amount of strong pain medicine you need afterward. If you're having ACL reconstruction with your own tendon and haven't been using opioids regularly, you may be able to join.
Burlington, New JerseyAges 14 years+ - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06601218RecruitingPhase 1
Daily oral cannabis for cancer patients with solid tumors
This trial tests whether taking a daily oral cannabis (marijuana) dose is safe for people with advanced solid tumors (cancer that has spread). It's looking for people who are already on a stable cancer treatment and want to see if adding cannabis affects their symptoms or how they feel.
Lexington, KentuckyAges 18 years+ - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT06182436Recruiting
Virtual reality for pain during eczema injection
This trial tests whether playing a virtual reality game during a dupilumab injection (for eczema) can help reduce pain and anxiety. It's for kids and teens aged 6 to 17 who are already taking or about to start this medicine.
Montreal, QuebecAges 6–17 - NCT04042844RecruitingPhase 2
Single injection treatment for chronic low back disc pain
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Birmingham, AlabamaAges 18 years+ - NCT06245239Recruiting
Measuring pain in young children after surgery
This study looks at whether a non-invasive tool called perfusion index can help doctors measure pain in children under 3 years old after hypospadias repair surgery. This could lead to better pain management for young children who cannot easily describe their pain.
Asyut, Assuit GovernorateAges 1 day–3 years - NCT06587607Recruiting
VR mindfulness training for veterans with spinal cord injury
This study tests whether mindfulness training with virtual reality can help veterans with spinal cord injury manage chronic pain. It is done from home using a VR headset and group video calls.
Houston, TexasAges 18 years+ - NCT06592378Recruiting
Managing pain after a broken bone with a smartphone app
This trial tests whether a smartphone app can help patients manage opioid pain medication safely after being discharged from the emergency room with a broken bone. If you have a simple fracture and plan to take opioids for pain, the app may help you track your use and recovery.
Providence, Rhode IslandAges 6 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.