Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,751 recruiting studies in this area right now.
By phase
- Not applicable3,098
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio47
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,750 total
- NCT07099157RecruitingPhase 4
Brivudine for Shingles: Safety and Effectiveness Study
This trial tests whether the antiviral drug brivudine is safe and effective for treating shingles (herpes zoster). It compares brivudine to other antiviral treatments like famciclovir, and may be an option if you are looking for a shorter treatment course.
BeijingAges 18 years+ - NCT07099560Recruiting
Comparing two numbing blocks for hypospadias repair in children
This study compares two ways to numb the lower belly and groin area for children having hypospadias repair. It tests if a newer injection method (sacral erector spinae block) works as well as the standard method (caudal block) to control pain during and after surgery.
Tanta, El-Gharbia GovenorateAges 1–5 - NCT07100782RecruitingPhase 3
Estrogen & pain trial for endometriosis pelvic pain
This study tests whether a drug called relugolix CT can reduce pelvic pain from endometriosis. You'll have brain scans and pain tests to measure how your body processes pain. It might help if other treatments haven't worked well.
Ann Arbor, MichiganAges 18–49 - NCT07101250RecruitingPhase 4
Study of acetazolamide before laparoscopic hysterectomy
This trial tests a medication called acetazolamide given before surgery to see if it can help prevent shoulder pain after a laparoscopic hysterectomy. If you are a woman scheduled for this type of hysterectomy, you may be able to join.
Greenville, South CarolinaAges 21–65 - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07103135RecruitingPhase 1
Testing an accelerated TMS for chronic pain
This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) — a non-invasive treatment that uses magnetic pulses to stimulate the brain — to see if it can reduce chronic pain. If you have long-term pain that hasn't responded well to at least two medications, this trial might be a good option for you.
Minneapolis, MinnesotaAges 18 years+ - NCT07103317Recruiting
Understanding heart blood flow in chest pain without blockages
This study looks at people who have chest pain but don't have major blockages in their heart arteries. It aims to understand how the tiny blood vessels and artery spasms might be causing symptoms, using special heart tests.
Prague, Česká RepublikaAges 18 years+ - NCT07108192Recruiting
Hand holding and stress ball for cataract surgery comfort
This study tests whether holding a stress ball or having your hand held during cataract surgery can help lower pain and anxiety. It is for people having their first cataract surgery and who are not on certain medications.
SakaryaAges 18 years+ - NCT07108400Recruiting
Combination therapy for hip osteoarthritis pain and function
This trial tests if combining ultrasound-guided hyaluronic acid injections with laser therapy and rehabilitation can improve hip function and reduce pain in people with hip osteoarthritis. It may be an option if you have moderate hip pain and are not currently taking anti-inflammatory medications.
Catanzaro, CZAges 18–85 - NCT07109557Recruiting
Baduanjin for recovery after knee replacement
This study tests whether doing Baduanjin, a gentle mind-body exercise, helps people recover better after knee replacement surgery. It focuses on patients who are in stable condition and willing to try the exercise.
YalovaAges 18–70 - NCT07109843Recruiting
Boswellia for pain and sensitivity in healthy volunteers
This trial tests whether a supplement called Boswellia serrata (frankincense) can change how your body processes pain and touch. It is for healthy people who do not have chronic pain or use certain medications.
Graz, StyriaAges 18 years+ - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07109895Recruiting
Custom Insole with Nerve Stimulation for Diabetic Foot Ulcers
This trial tests a custom insole that uses mild electrical stimulation to help heal diabetic foot ulcers. It aims to reduce pain and improve wound healing compared to standard care.
Lahore, Punjab ProvinceAges 18–60 - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT07112404Recruiting
Dry Needling for Low Back Pain Study
This study tests a type of dry needling (inserting thin needles into muscles) to see if it helps people with and without chronic low back pain. You may join if you have no recent low back pain or if you have had low back pain for at least 3 months, as long as you have not had major back surgery or certain treatments.
Galveston, TexasAges 18–65 - NCT07114003Recruiting
Virtual reality for pain and anxiety during wound dressing changes
This study tests whether using virtual reality during wound dressing changes can help reduce pain and anxiety and improve satisfaction for people with pressure sores (bedsores).
Mersin, TarsusAges 18 years+ - NCT07114913Recruiting
Carpal tunnel symptom location and pain study
This study looks at where carpal tunnel syndrome symptoms show up and how your body processes pain. By understanding this, doctors hope to find better ways to treat it.
Istanbul, UsküdarAges 18–65 - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT07116408RecruitingPhase 4
Numbing spray for headaches after brain bleed
This study tests if a numbing spray applied inside the nose can help reduce headaches in people who have had a brain bleed from a ruptured aneurysm. The treatment targets a nerve cluster linked to headache pain.
Dayton, OhioAges 18 years+ - NCT07117032RecruitingPhase 1
Radiation therapy for cancer-related stomach pain
This trial tests a type of radiation therapy (SBRT) to treat severe stomach pain caused by cancer pressing on nerves near the stomach. It aims to provide pain relief without the need for a standard nerve block procedure.
Cleveland, OhioAges 18 years+ - NCT07119255Recruiting
PRP acupuncture for long-term neck pain from muscle tightness
This study tests whether a treatment called platelet-rich plasma (PRP) acupuncture — using your own blood proteins — can reduce chronic neck pain caused by a common muscle condition. It may be a good option if you have had neck pain for months and want a non-surgical approach.
JakartaAges 18–59 - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07119983Recruiting
Stress ball for pain relief during diabetic foot wound cleaning
This study tests whether squeezing a stress ball during wound cleaning (debridement) can help reduce pain and distress for people with diabetic foot ulcers. If you're having this procedure for the first time and have mild pain or more, this simple technique may offer comfort.
Mersin, TarsusAges 18 years+ - NCT07122453RecruitingPhase 1
Study of CNTX-3001 for severe chronic low back pain
This trial tests a medicine called CNTX-3001, given as a spinal injection, for people with long-term, severe low back pain that hasn't improved with other treatments.
Napa, CaliforniaAges 18–75
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,751 recruiting pain medicine studies from the U.S. registry right now, out of 6,825 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.