Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06473896Recruiting
Pain relief after gallbladder surgery using ketamine or dexmedetomidine
This trial tests if adding ketamine or dexmedetomidine during anesthesia can prevent increased pain after surgery. It may help people having laparoscopic gallbladder removal feel better after the procedure.
Be’er Ya‘aqovAges 18–85 - NCT06315933Recruiting
Anesthesia and brain development in children with congenital scoliosis
This study looks at how anesthesia (medicine used to put children to sleep during surgery) may affect the brain development of children with congenital scoliosis. It will help doctors understand how to make anesthesia safer for children with this condition.
Beijing, Beijing MunicipalityAges 6–16 - NCT06306833Recruiting
Biofeedback therapy for chronic low back pain
This study tests if a therapy that uses special sensors to help you relax your back muscles (called surface EMG biofeedback) can reduce chronic low back pain. If you have ongoing low back pain for at least 3 months, you may be able to join.
Karachi, SindhAges 25–75 - NCT06274333RecruitingPhase 3
Easing bladder discomfort after kidney stone surgery
This trial tests if adding dexmedetomidine or tramadol to standard paracetamol can reduce bladder pain and discomfort from the urinary catheter used during kidney stone removal. It may help patients feel more comfortable after their procedure.
Cairo, Cairo GovernorateAges 20–50 - NCT06258863Enrolling by invitation
Comparing incision types in breast reconstruction after mastectomy
This study compares different types of surgical cuts (incisions) used during breast reconstruction after mastectomy. It looks at which incision gives the best cosmetic result and causes the fewest problems. Researchers want to find out which technique is best for you.
Wuhan, Hongshan DistrictAges 18 years+ - NCT06320262Recruiting
Wet cupping (Hijama) for fibromyalgia pain
This trial tests whether wet cupping (Hijama) can help reduce pain in women with fibromyalgia. It is for women who have had moderate to severe pain and have not taken certain pain medications in the past year.
CairoAges 18–55 - NCT06313359Recruiting
Understanding fall risk in people with nerve pain from cancer treatment
This study looks at how nerve damage from cancer treatment affects fall risk and quality of life. By comparing people with nerve symptoms to those without, researchers hope to find ways to improve safety and daily living.
Dallas, TexasAges 18 years+ - NCT06042621Enrolling by invitation
Improving communication in the ICU for patients, families, and staff
This study looks at how doctors, nurses, and other healthcare team members talk with patients and their families in the intensive care unit (ICU). It aims to improve understanding and support for everyone involved.
Chicago, IllinoisAges 18 years+ - NCT06075966Enrolling by invitation
A new surgery for lumbar disc disease without fusion
This trial tests a surgical technique that treats a damaged disc in your lower back without permanently fusing the bones together. It may be an option if you have had at least 3 months of other treatments like physical therapy or medication and they have not helped enough.
Jinan, ShandongAges 18–85 - NCT06078813RecruitingPhase 1/Phase 2
Higher dose spine radiation for limited spread cancers
This trial tests a higher dose of focused radiation (SABR) for people whose solid cancer has spread to the spine in a few spots. The goal is to control those tumors with fewer side effects.
CorkAges 18 years+ - NCT05991687Recruiting
Safe disposal of leftover pain pills after surgery
This trial helps people who are new to opioids learn how to safely dispose of leftover pain medication after outpatient surgery, reducing the risk of misuse.
Ann Arbor, MichiganAges 18 years+ - NCT05969457RecruitingPhase 3
Local pain-numbing injection before surgery for hysterectomy
This Phase 3 study tests whether a preventive numbing medicine injection before a vaginal hysterectomy (using the vNOTES approach) can reduce pain afterward. It may help with comfort and recovery after surgery for non-cancer reasons.
Le HavreAges 18–70 - NCT06039566RecruitingPhase 3
NAC vs placebo for pain after hysterectomy
This trial tests if a medicine called N-acetylcysteine (NAC) can reduce the need for strong pain pills after hysterectomy surgery. If you are having a laparoscopic or robotic hysterectomy, this study may help you recover with less opioid pain medicine.
Charleston, South CarolinaAges 18 years+ - NCT05978414Recruiting
Jaw and Pelvis Connections in Women After Prolapse Surgery
This study looks at how the jaw joint and pelvis may be connected in women who have had surgery for pelvic organ prolapse and also have endometriosis. It aims to find new links that could help guide treatment.
PoznanAges 18–60 - NCT06031571Recruiting
Cupping vs myofascial release for neck pain
This trial compares two hands-on treatments for long-term neck pain that isn't caused by injury or serious spine problems. It aims to see if dynamic cupping or myofascial release works better to relieve pain.
Qina, Qena GovernorateAges 18–40 - NCT06121466RecruitingPhase 4
Belly wall injections for abdominal pain study
This study tests whether anesthetic injections into the belly wall can help relieve abdominal pain that feels like it's coming from the muscles or tissues of the belly wall itself. It may be a good option if you have localized pain and haven't tried these injections yet.
Portland, OregonAges 18–100 - NCT05974384Recruiting
Music during closed treatment to ease wrist fracture pain
This study looks at whether playing music while doctors perform a closed procedure to realign a broken wrist can reduce pain and anxiety. It may help by making the procedure feel calmer for some people.
Sabadell, BarcelonaAges 18–100 - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT05779852Recruiting
Hypnosis to ease new foot amputation wound pain
This trial tests whether auto-hypnosis (a self-guided calming technique) can reduce pain after a toe or multiple toes are removed. It is for adults who are newly after an amputation and have moderate pain soon after the first dressing.
RennesAges 18 years+ - NCT05748366Recruiting
Ultrasound-guided pain block for broken ribs
This trial tests an ultrasound-guided nerve pain block (in the serratus anterior area) to help relieve pain from one side of recently broken ribs. If it works well, it may reduce how much IV pain medicine or opioid tablets you need while you recover.
York, PennsylvaniaAges 18 years+ - NCT05757609Recruiting
Brain stimulation therapy for chronic low back pain
This trial tests whether a non-invasive brain stimulation treatment can improve physiotherapy results for people with long-lasting low back pain. You may be asked to do questionnaires and follow a treatment plan, and some people may be able to reduce pain or improve function.
GenevaAges 18–65 - NCT05848375Recruiting
Rotator cuff surgery done with special anesthesia alone
This trial studies rotator cuff repair surgery when the surgeon uses a regional anesthesia method (numbing the arm area) rather than general anesthesia alone. It may help people with certain types of rotator cuff tendon injuries who are good candidates for outpatient surgery and this anesthesia approach.
NantesAges 18 years+ - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.