Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT05303805RecruitingPhase 4
Sevoflurane gel for painful, slow-healing leg ulcers
This trial studies a topical (skin-applied) form of sevoflurane to help painful leg ulcers that are not healing on their own. If you have ongoing ulcer pain and can report it reliably, you may be considered for this treatment study.
PragueAges 18 years+ - NCT06317870Recruiting
Nerve block vs spinal morphine for hip surgery pain
This trial compares two types of pain relief after a hip replacement: a nerve block (injecting numbing medicine near the hip) versus a small dose of morphine given through a spinal needle. It aims to find out which option works better with fewer side effects.
Lausanne, Canton of VaudAges 18 years+ - NCT07771205Recruiting
Aromatherapy for surgical anxiety and pain
This study tests whether breathing in relaxing scents before surgery can reduce anxiety and pain. If effective, it could offer a simple, drug-free way to help you feel calmer during your procedure.
Stockton, CaliforniaAges 18 years+ - NCT07775053Enrolling by invitation
Pain relief study for breast cancer surgery
This study tests whether adding tramadol to a standard numbing medicine (ropivacaine) makes pain control better after breast cancer surgery. If you're having a mastectomy, this could help reduce pain and improve recovery.
Sargodha, Punjab ProvinceAges 20–70 - NCT07771816Enrolling by invitation
Mouth rinse and cold therapy for lower molar pain
This study tests whether using different strengths of a disinfectant rinse inside the tooth, sometimes combined with cold therapy, can reduce pain after a type of root canal treatment for lower molars. It aims to find the most comfortable and effective approach for managing post-procedure pain.
Cairo, Cairo GovernorateAges 15–40 - NCT07767383RecruitingPhase 4
Improving sleep quality after knee surgery with added sedation and nerve blocks
This trial tests whether adding a calming medicine called dexmedetomidine to a nerve block around the knee can help you sleep better after arthroscopic knee surgery. It aims to find if this combination reduces sleep problems during recovery.
Nantong, JiangsuAges 18–85 - NCT07775183Recruiting
Balance training with visual targets for fall prevention
This study tests a balance training program that uses visual targets. It aims to see if this training helps improve balance, daily function, and reduce fear of falling in people who have had a fall recently.
Istanbul, IstanbulAges 18–95 - NCT07772141Recruiting
Palmitoylethanolamide for chronic low back pain
This trial tests whether a natural substance called palmitoylethanolamide (PEA) can help reduce chronic low back pain by calming the nervous system and reducing inflammation. It might be an option for people with ongoing pain from a disc problem who haven't had surgery.
Banī SuwayfAges 18–65 - NCT07772661Enrolling by invitation
Therapy options for deep gluteal pain syndrome
This study compares two treatments for buttock pain that gets worse when you sit. One is a type of hands-on therapy, the other adds sound wave therapy. The goal is to see which helps reduce pain and improve movement.
Sialkot, Punjab ProvinceAges 25–45 - NCT07769385Enrolling by invitation
Robotic fish and aquarium to ease pain and fear in children
This trial tests whether using a robotic fish or watching an aquarium can help reduce pain, fear, and anxiety in children during medical procedures. It might make the experience more comfortable for your child.
Bingoel, TurkeyAges 5–10 - NCT07770139Enrolling by invitation
Online yoga and breathing for student stress relief
This study compares two online programs—one with yoga poses and breathing, the other adding a special breathing technique—to see if they help reduce stress and improve well-being in university students.
IstanbulAges 18–30 - NCT07770932Recruiting
Pain relief after hip replacement surgery
This study compares two types of nerve blocks for pain relief after hip replacement surgery. It aims to find which method reduces pain and improves recovery.
Istanbul, BagcilarAges 18–80 - NCT07772674Enrolling by invitation
Nerve gliding exercises with or without shockwave for buttock pain
This study compares two treatments for pain in the buttock that may spread down the back of the thigh. One group gets nerve gliding exercises alone, the other gets those exercises plus shockwave therapy, a treatment that uses sound waves to help healing.
Sialkot, Punjab ProvinceAges 2.1 years–45 years - NCT07769619Recruiting
AI and brain scans for chronic pain in rheumatoid arthritis
This study uses AI, brain scans, and blood tests to understand chronic pain in rheumatoid arthritis (RA). It may help find better ways to treat pain in the future.
WroclawAges 18 years+ - NCT06128772Recruiting
Acupuncture study for chronic pain
This study tests if battlefield acupuncture, a specific type of ear acupuncture using tiny needles or tacks, can help veterans with chronic pain. It may be a good option if you have a history of substance use disorder and are interested in a non-drug approach to pain relief over 16 weeks.
Bedford, MassachusettsAges 18 years+ - NCT06449547Recruiting
Risk factors for anxiety and depression in shingles nerve pain
This study looks at what makes people with shingles nerve pain more likely to feel anxious or depressed. By joining, you'll help doctors understand how to better support patients like you.
Wuhan, HubeiAges 18 years+ - NCT06509087Recruiting
Combining CT and MRI for joint pain procedure
This study tests a procedure called transarterial microembolization for chronic shoulder or knee pain that hasn't improved with other treatments. It uses both CT and MRI to guide the procedure and see if it can help reduce pain.
TaipeiAges 20–80 - NCT07766720Recruiting
Eggshell membrane and turmeric supplements for exercise recovery
This trial tests whether taking eggshell membrane, curcumin (turmeric), or both together can help your muscles recover faster after intense exercise. It may reduce soreness and help you bounce back sooner.
College Station, TexasAges 18–40 - NCT07758920RecruitingPhase 2
New tablet for long-term shingles pain
This trial tests a new tablet called HL-1186 for treating post-herpetic neuralgia (long-lasting pain after shingles). It compares the new drug to pregabalin, a standard treatment, to see if it's safer and more effective.
BeijingAges 18 years+ - NCT07763327Recruiting
Wearable device and app for posture in university students
This study tests whether using a wearable posture belt, a phone app, and simple exercises can improve posture in university students. If you sit a lot and notice postural issues, this may help improve your neck, shoulder, and back alignment.
IslamabadAges 18–30 - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT07762690Enrolling by invitation
Neck rehabilitation for chronic migraine
This study tests a neck exercise program designed to improve neck function and reduce migraine symptoms. It may help people whose migraines are linked to neck problems.
Banī Suwayf, EgyptAges 18–55 - NCT07761689Recruiting
Kangaroo care for pain relief during newborn jaundice light therapy
This study tests whether holding your baby skin-to-skin (kangaroo care) during light therapy for jaundice can help reduce their pain and discomfort. It aims to see if this simple comfort measure is beneficial.
IstanbulAges 2 days–1 week - NCT07765082Recruiting
Textured insoles for foot function in plantar fasciopathy
This trial tests whether textured shoe insoles can improve foot function and reduce pain in people with long-standing plantar fasciopathy (a common cause of heel pain). You may join if your condition has lasted at least 3 months and you can walk for 20 minutes, but you must be otherwise healthy without recent leg injuries or other balance issues.
Lexington, KentuckyAges 18–55
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.