Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07617545Recruiting
Nerve blocks for pain relief in kids' upper belly surgery
This trial compares two types of numbing injections (nerve blocks) given during surgery to help reduce pain afterward in children having upper abdominal surgery. The goal is to find which method works better to keep kids more comfortable after their operation.
AlexandriaAges 6–12 - NCT07618247RecruitingPhase 1
Testing a new drug in healthy adults
This is an early-stage study testing a new investigational drug called IG001119 in people who are in good health. Researchers will give increasing doses to small groups to learn how the drug is processed by the body and to check for any side effects.
Adelaide, South AustraliaAges 18–65 - NCT06706037Recruiting
Reformer exercise for chronic muscle and joint pain
This study tests if Reformer Pilates exercises can reduce pain for people with long-term muscle or joint pain. It may help you feel better and move more easily.
Ankara, Select StateAges 30–50 - NCT06706531Recruiting
Dry needling plus physical therapy for plantar fasciitis
This study tests whether adding dry needling (a technique using thin needles to release muscle knots) to standard physical therapy works better than physical therapy alone for treating long-term heel pain known as plantar fasciitis.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06424834RecruitingPhase 2/Phase 3
Targeted medicines for chest pain without blocked arteries
This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.
Palo Alto, CaliforniaAges 18 years+ - NCT06707870Recruiting
Neck exercises for chronic pain relief
This trial compares two different treatments for long-lasting neck pain: a special exercise that helps with neck posture (cervical retraction) and a gentle manual therapy technique (facet oscillatory mobilization). It aims to find which method is better at reducing pain and improving neck movement.
Peshawar, KPKAges 35–50 - NCT06707532Recruiting
Muscle relaxants for safer heart rhythm treatment
This study tests if giving muscle relaxants before a heart ablation procedure can protect muscles from damage. Ablation uses energy to fix irregular heartbeats, and muscle relaxants might make it safer.
Wroclaw, Lower Silesian VoivodeshipAges 18–90 - NCT06707857Recruiting
TNT Treatment for Rotator Cuff Tendon Pain
This study tests if a treatment called TNT can reduce shoulder pain, improve movement, and help with daily activities in people with rotator cuff tendon problems. It may be a good option if you've had shoulder pain for at least three months.
Lahore, Punjab ProvinceAges 18–65 - NCT06707363Recruiting
Psychological factors and pain after orthopedic surgery
This study looks at how your thoughts and feelings affect your pain after orthopedic surgery. Researchers want to understand these factors to improve care for future patients.
Krakow, MalopolskaAges 18–65 - NCT04081896Recruiting
Rehab program for adults with spine pain
This trial studies whether a prescribed physical therapy (rehab) program helps people with spine pain. It may help by improving pain and function when a clinician has already recommended rehabilitation.
San Diego, CaliforniaAges 18–89 - NCT06709690Recruiting
AI-powered PET/MR scanner for children with suspected cancer
This study tests a new, fast, and quiet AI-powered PET/MR scanner to take detailed pictures of children with suspected cancer. It aims to make the imaging experience easier and more comfortable for kids.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT03596424Recruiting
Testing ketamine and dexmedetomidine during lung surgery
This trial studies whether the anesthesia medicines ketamine and dexmedetomidine can improve care during elective lung (video-assisted) surgery. It may help with comfort during and after the operation, depending on how these medicines affect pain and recovery.
Montreal, QuebecAges 18–80 - NCT07609914RecruitingPhase 4
Safety study of an extra dose of rimegepant for migraine
This study tests whether taking an additional dose of rimegepant (a migraine medicine you may already use) is safe and helpful for adults with migraine. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist—a type of medicine that blocks a protein involved in migraine pain.
Canoga Park, CaliforniaAges 18 years+ - NCT04939207Recruiting
Test safer, cheaper scans for suspected coronary artery disease
This study compares new imaging methods to see how well they work and whether they can lower costs for people with suspected coronary artery disease. It may help by using different scan approaches while keeping patient safety in mind.
Eindhoven, North BrabantAges 18 years+ - NCT05980793Recruiting
Nerve Treatment for Finger Joint Osteoarthritis
This study tests if a procedure that quiets the nerves around a painful finger joint (PIP joint denervation) can reduce pain and improve hand function for people with osteoarthritis. It offers a possible alternative before considering more invasive surgery.
StockholmAges 18 years+ - NCT07607249Enrolling by invitation
Floating Needle Treatment for Stomach Issues After Knee Surgery
This trial tests whether a traditional Chinese acupuncture technique called 'floating needle' can help with stomach and bowel problems that sometimes happen after knee surgery under general anesthesia. You would receive this treatment along with standard post-surgery care to see if it reduces nausea, constipation, or other digestive issues.
Guangzhou, GuangdongAges 18 years+ - NCT07604376Recruiting
Nerve Block Pain Relief After Cesarean Delivery
This study tests whether a nerve-numbing injection in the abdomen helps reduce pain after a cesarean (C-section) delivery. The injection uses a local anesthetic to numb the area around your surgical wound, potentially reducing pain and the need for stronger pain medicines after surgery.
Târgu Mureş, Mureș CountyAges 18 years+ - NCT07610044Enrolling by invitation
Pelvic Floor vs. Swiss Ball Exercises for Chronic Low Back Pain
This study tests two exercise approaches—pelvic floor exercises and Swiss ball exercises—to see which better reduces long-term lower back pain in women. Both aim to strengthen core muscles that support your spine.
Lahore, Punjab ProvinceAges 18–35 - NCT07607899Recruiting
Virtual Reality to Help Chronic Pain in Older Adults
This study tests whether wearing a virtual reality headset can help reduce chronic pain and improve well-being in people 65 and older. Researchers believe VR may help you manage long-lasting pain by engaging your mind in immersive experiences.
Québec, QuebecAges 65 years+ - NCT07603960Recruiting
Cold therapy to ease endometriosis pelvic pain
This study tests whether exposing your whole body to very cold air (below freezing) can reduce chronic pelvic pain from endometriosis and improve your quality of life. Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus, often causing pain.
Edinburgh, ScotlandAges 16 years+ - NCT07608939Recruiting
Pain relief after root canal treatment with different sealers
This study compares how much pain you experience after root canal treatment depending on which type of sealing material is used. Root canal treatment removes infected tissue from inside a tooth; this trial helps dentists find the approach that causes the least post-treatment discomfort.
LefkaAges 18–60 - NCT07605650Recruiting
Fascia Release Technique for Forward Head Posture
This study tests whether adding a specialized soft-tissue technique (IASTM) to standard physical therapy helps improve forward head posture better than therapy alone. Forward head posture is when your head juts forward, which can cause neck pain and stiffness.
Giza, Giza GovernorateAges 18–30 - NCT07603674Recruiting
Personalized Primary Care for Muscle and Joint Pain
This trial tests whether tailoring musculoskeletal pain treatment to each patient's unique needs in primary care works better than standard care. You'll work with your regular doctor to find the approach that works best for your specific pain.
StockholmAges 18 years+ - NCT07605546Recruiting
Radiation Therapy for Cancer Pain Relief
This trial tests whether a focused radiation treatment called SRS (stereotactic radiosurgery) can help relieve severe cancer pain that hasn't improved with strong pain medications. You would receive a one-time radiation procedure aimed at pain-causing areas in your brain.
Los Angeles, CaliforniaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.