Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06611176Recruiting
Pain relief after esophageal lesion removal using a numbing medication
This trial tests whether injecting a long-acting numbing medicine (levobupivacaine) into the esophagus after removing a large lesion can reduce pain. If you're scheduled for this procedure, you may experience less discomfort afterward.
GroningenAges 18 years+ - NCT07693621Recruiting
Pain relief medicine added to numbing drug for gallbladder surgery
This trial tests if adding dexmedetomidine or magnesium to a standard numbing medication (bupivacaine) injected into the belly during gallbladder surgery can improve pain control and recovery. It aims to find a better way to manage pain after surgery.
AlexandriaAges 18–60 - NCT06450444Recruiting
Neuromodulation implant for chronic or frequent migraine
This trial tests a new implantable device that uses mild electrical pulses to prevent migraines. It is for people who have tried at least three migraine prevention medicines without success and still have frequent migraines.
Broadmeadow, New South WalesAges 18–84 - NCT07423910Recruiting
Numbing injections for better recovery after hernia surgery
This study looks at two types of numbing injections (TAP and RS blocks) to see which helps people recover better after groin hernia surgery. If you are having a planned single-side hernia repair, you might qualify to join.
TampereAges 18 years+ - NCT07451431RecruitingPhase 4
Mirogabalin for diabetic nerve pain study
This study tests a new pain medicine called Mirogabalin for people with diabetic nerve pain that hasn't gotten better with usual treatments. It aims to see how well the drug works and if it is safe.
DhakaAges 40 years+ - NCT07449078Recruiting
Cognitive functional therapy for chronic ankle sprain
This trial tests a type of talk therapy that teaches you new ways to move and think about your ankle. It may help people who have ongoing pain or instability from an old sprain.
Istanbul, AtaşehirAges 18–65 - NCT06963671Enrolling by invitation
Blood flow restriction therapy for ulnar-sided wrist pain
This study tests using a blood pressure cuff during hand therapy to see if it helps reduce ulnar-sided wrist pain and improve hand function.
Redwood City, CaliforniaAges 18 years+ - NCT07448857Recruiting
Scapula movement and muscle activity in upper string players with neck pain
This study looks at how the shoulder blade moves and muscles work in violin and viola players who have neck pain. It may help understand why neck pain happens and how to treat it better.
Taipei, TaiwanAges 18 years+ - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT06991192Recruiting
ACL recovery with exercise and emotional support
This study tests a rehab program for teens and young adults who had ACL surgery. It combines physical therapy with extra mental and emotional support to help them get back to sports safely.
Bloomington, MinnesotaAges 15–21 - NCT05675527RecruitingPhase 4
Platelet gel (PRP) for shoulder arthritis pain
This trial tests whether platelet-rich plasma (PRP), a blood-based treatment, can reduce pain from shoulder (glenohumeral) osteoarthritis. It also looks at whether PRP works for people who had temporary relief from a numbing/shock injection into the joint.
New York, New YorkAges 18–100 - NCT07019818RecruitingPhase 4
Esmolol vs. sufentanil for recovery after gallbladder surgery
This trial tests two different medicines given during gallbladder surgery to see which one helps you recover better. One medicine (esmolol) controls heart rate, while the other (sufentanil) is a strong painkiller. The goal is to find out which approach leads to a smoother recovery after your surgery.
Brive-la-Gaillarde, FranceAges 18 years+ - NCT06775431RecruitingPhase 3
Comparing two drugs to prevent shivering during C-section
This trial tests two ways of giving a medicine (pethidine) to prevent shivering during a C-section with spinal anesthesia. It aims to find which method works better.
Alexandria, Alexandria GovernorateAges 20–40 - NCT06598852Recruiting
Nerve block pain relief methods for chest surgery
This trial compares different nerve block techniques to see which provides better pain relief after thoracoscopic (chest scope) surgery. It could help find a way to reduce pain and minimize opioid use during recovery.
Qinhuangdao, HebeiAges 18–70 - NCT07440849Recruiting
Core stability and pelvic exercises for sacroiliac joint pain
This study tests whether core stability and pelvic clock exercises can reduce pain in women with sacroiliac joint dysfunction after childbirth. It may help you if you are a new mom with significant lower back or pelvic pain.
Sargodha, Punjab ProvinceAges 25–35 - NCT05992883RecruitingPhase 3
Comparing two injections for thumb arthritis pain
This study tests whether an NSAID injection or a corticosteroid injection works better for thumb base arthritis. If you have ongoing pain despite using things like ibuprofen, ice, or a brace, this trial may help find which treatment offers better relief.
Rochester, MinnesotaAges 40 years+ - NCT07415941Recruiting
Mindfulness and nerve stimulation for back pain and depression
This trial tests if combining mindfulness-based meditation with a gentle nerve stimulation device (applied to the ear) can help people aged 50–85 with chronic low back pain and depression. The goal is to reduce pain and improve mood without changing your current medications.
Tallahassee, FloridaAges 50–85 - NCT05880212Recruiting
STOPS low back and leg pain approach for Bangladesh
This trial tests a specific physiotherapy program (“STOPS approach”) for people with long-lasting low back pain or leg pain from the back. It aims to see if the structured treatment, delivered by trained physiotherapists, improves pain and function over about 10 weeks.
Dhaka, UttaraAges 18–65 - NCT07413731Recruiting
Medication tapering with spinal cord stimulation
This trial tests how changing your pain medications while using a spinal cord stimulator affects your nervous system. It may help people with chronic lower back pain find the best way to manage their pain and reduce reliance on strong drugs.
WilrijkAges 18 years+ - NCT07062146Recruiting
Reiki for pain after back fusion surgery
This study tests whether Reiki (a gentle hands-on energy therapy) can help reduce pain after lower back fusion surgery. It aims to see if adding Reiki to standard care improves recovery.
ParisAges 18–75 - NCT05806021RecruitingPhase 4
Tested different cortisone doses for knee osteoarthritis pain
This trial compares different doses of injected cortisone (triamcinolone) directly into the knee to see which dose helps knee osteoarthritis pain most. You may be enrolled in a group receiving a 5 mg, 10 mg, or 40 mg dose if you meet the study’s knee and health requirements.
Montreal, QuebecAges 50 years+ - NCT04042844RecruitingPhase 2
Single injection treatment for chronic low back disc pain
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Birmingham, AlabamaAges 18 years+ - NCT06802120Recruiting
Osteopathic care after lower back surgery
This trial tests whether osteopathic treatments can help reduce pain and improve daily life after spinal fusion surgery. It is for people who still have ongoing mechanical back pain four weeks after surgery.
ParisAges 18–75 - NCT07398352Recruiting
Regional anesthesia effects on brain oxygen in shoulder surgery
This trial studies how regional anesthesia affects oxygen levels in the brain and a key artery during shoulder surgery. It aims to find which anesthesia method works best for oxygen supply.
SanliurfaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.