Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65 - NCT06489353Recruiting
Watching video or blowing pinwheel for kids during IV
This study tests whether watching a video or blowing a paper pinwheel helps children feel more comfortable during an IV or blood draw. It is for children ages 3 to 6 who are in the hospital and do not have certain health conditions.
TaichungAges 3–6 - NCT06492148Recruiting
Myofascial Release for Period Pain in Women
This study tests a gentle hands-on technique called myofascial release to see if it can reduce period pain in women who have primary dysmenorrhea (painful periods without an underlying condition). If you have moderate to severe cramps and don't use hormonal birth control, you may be able to join.
AnkaraAges 18–35 - NCT05968664Recruiting
Test whether new spinal cord stimulation settings improve chronic pain
This trial studies whether changing the “stimulation pattern” of spinal cord stimulation can reduce long-lasting pain and improve daily function. You might be a good candidate if you have chronic trunk or leg pain and have already tried multiple pain treatments without enough relief.
Houston, TexasAges 22 years+ - NCT06503523Recruiting
Brain activity during pain and itch
This study tests whether imagining movements changes brain activity when you feel pain or itch. It could help scientists understand how the brain responds to these sensations.
GistrupAges 18–60 - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT06702904Recruiting
Neuroprosthesis for phantom limb pain relief
This study tests a new type of artificial limb (neuroprosthesis) that sends signals back to your brain to help reduce phantom limb pain and improve your daily life. You may be able to join if you have had an arm or leg amputation at least 6 months ago and have persistent pain.
MoscowAges 18–65 - NCT06070766Recruiting
At-home ketamine study for chronic conditions
This trial tests a ketamine protocol you can use at home. It may help if you have a long-term health condition.
Bigfork, MontanaAges 18 years+ - NCT06038409Recruiting
Ketamine therapy for chronic conditions
This trial tests if ketamine can help people with long-term health issues. It aims to find new treatments for chronic conditions that haven't responded well to other therapies.
Helena, MontanaAges 18 years+ - NCT06704490Recruiting
Chronic pain after planned cesarean section
This study looks at how common chronic pain is after a planned cesarean section and what factors might increase that risk. It could help doctors better prevent and manage long-term pain after delivery.
Wuhan, HubeiAges 20–50 - NCT07615725Recruiting
Dry Needling for Lower Leg Pain in Multiple Sclerosis
This study tests whether dry needling—a technique using thin needles to treat muscle pain—can help reduce lower leg pain in people with multiple sclerosis. Researchers want to see if this treatment can safely improve pain and function.
Tampa, FloridaAges 18–80 - NCT07617545Recruiting
Nerve blocks for pain relief in kids' upper belly surgery
This trial compares two types of numbing injections (nerve blocks) given during surgery to help reduce pain afterward in children having upper abdominal surgery. The goal is to find which method works better to keep kids more comfortable after their operation.
AlexandriaAges 6–12 - NCT07616583Recruiting
Vertebral Fracture Treatment with Precise Cement Injection
This study tests a new method for treating recent spine fractures caused by weak bones (osteoporosis). A surgeon injects special cement into the broken vertebra to stabilize it and reduce pain. You'll be one of the first to receive this standardized technique.
Beijing, Beijing MunicipalityAges 50–80 - NCT07618650Enrolling by invitation
Pain Relief Blocks for Children After Appendix Surgery
This study compares two different injection techniques to reduce pain after appendix removal surgery in children ages 7–12. Both techniques use ultrasound (sound waves) to guide a numbing medication to nerves near the surgical area, and researchers want to see which works better.
TantaAges 7–12 - NCT07615595Enrolling by invitationPhase 4
Dexamethasone to reduce side effects from spinal anesthesia during cesarean delivery
This study tests whether giving a steroid medication (dexamethasone) before spinal anesthesia can reduce uncomfortable side effects like nausea, vomiting, and low blood pressure during planned cesarean delivery. The goal is to help you feel better during and after your surgery.
Ho Chi Minh City, Ho Chi MinhAges 18 years+ - NCT07620119Recruiting
AI-assisted heart attack diagnosis in patients with LBBB
This study tests whether artificial intelligence can help doctors more accurately diagnose heart attacks in patients who have a specific heart rhythm pattern called Left Bundle Branch Block (LBBB). The goal is to improve emergency care by reducing delays in identifying who needs urgent treatment.
Konya, KaratayAges 18 years+ - NCT07614945Recruiting
Reflexology for Pain and Sleep in Fibromyalgia
This study tests whether reflexology—a massage technique applied to specific points on the feet and hands—can help reduce pain and improve sleep in women with fibromyalgia. Fibromyalgia causes widespread muscle pain and sleep problems, and this trial explores whether reflexology might offer relief.
Al Mansurah, Dakahlia GovernorateAges 18–65 - NCT07619651Recruiting
Pain relief methods after hypospadias repair in young boys
This trial compares two different numbing techniques to help manage pain after hypospadias surgery (a procedure to correct the urinary opening in boys). The goal is to find which method works better and is safer for young children.
KayseriAges 6 months–7 years - NCT07616648Recruiting
How Opioid Pain Drugs Affect Sleep and Mood in Cancer Patients
This study examines how opioid medications (strong pain relievers) impact sleep quality and emotional well-being in cancer patients with moderate to severe pain. Researchers will track your sleep patterns and mood to better understand these side effects.
HangzhouAges 18–75 - NCT07615829Recruiting
Dance Exercise and Health Benefits in Women
This study examines how regular dance exercise affects overall health and wellbeing in women. Researchers want to understand if dancing can improve physical fitness, mood, and other health markers.
Trikala, KariesAges 35–70 - NCT07620002Recruiting
Monitoring Pain Levels During Arm Surgery With Nerve Block
This study tests a device that measures pain levels during upper arm surgery when patients receive a nerve block (numbing medicine injected near the nerve). The goal is to understand if this monitoring tool helps doctors give the right amount of anesthesia so patients stay comfortable.
HaifaAges 18 years+ - NCT07615816Recruiting
Medical massage therapy for active-duty service members with recent lower back pain
This study tests whether massage therapy can help active-duty service members who have had lower back pain for 1–3 months. Researchers want to see if massage reduces pain and improves function.
Joint Base Lewis McChord, WashingtonAges 18–64 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.