Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+ - NCT05736744RecruitingPhase 2/Phase 3
Magnesium before surgery in children to reduce complications
This study tests whether giving magnesium before planned (elective) keyhole abdominal surgery can improve outcomes in children. It may help reduce problems related to anesthesia and muscle function during and after surgery.
Asyut, Assiut GovernorateAges 2–12 - NCT07352982Recruiting
Nerve stimulation for painful periods in young women
This study tests if a gentle nerve stimulation device placed near your ankle can reduce period pain. It is for young women with primary dysmenorrhea (painful periods without a known medical cause).
Kafr ash Shaykh, KafrelsheikhAges 20–25 - NCT07352683Recruiting
Nerve block for kids having belly surgery
This trial tests a nerve block to reduce pain in children aged 1–15 who are having open abdominal surgery. It aims to see if this approach improves recovery.
UppsalaAges 1–15 - NCT07351968RecruitingPhase 1
Study of HRS-2129 for knee osteoarthritis pain
This trial tests an investigational drug, HRS-2129, for people with knee osteoarthritis who have moderate to severe pain. It aims to see if the drug is safe and effective at reducing pain.
Nanjing, JiangsuAges 18–80 - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07348263Recruiting
Study on childhood eosinophilic fasciitis
This study looks at children diagnosed with eosinophilic fasciitis (a rare condition that causes skin swelling and stiffness) between 2000 and 2026. It aims to learn more about the disease and how it affects patients over time.
Birmingham, AlabamaAges Up to 18 years - NCT06367283RecruitingPhase 3
Metformin for treating hand osteoarthritis pain
This study tests whether metformin, a common diabetes medication, can reduce pain in hand osteoarthritis. You may be eligible if your hand pain is moderate to severe and you haven't taken metformin before.
Copenhagen, FrederiksbergAges 18 years+ - NCT06985784Recruiting
Virtual reality for head and neck cancer patients and caregivers
This study tests whether using virtual reality can help reduce depression, anxiety, and pain in people with head and neck cancer and their caregivers. You and your caregiver may be able to use VR headsets together as part of your treatment.
Duarte, CaliforniaAges 18 years+ - NCT07340970Recruiting
Sensory feelings during planned c-section
This study explores what sensations women feel during a planned cesarean delivery with spinal anesthesia. It may help understand how women experience touch, pressure, or other feelings during the procedure.
Vancouver, British ColumbiaAges 19 years+ - NCT07338916Recruiting
Finding the Best Dose of MEV90 for Shoulder Surgery Pain Relief
This study is testing different doses of a local anesthetic called MEV90 to find the best one for numbing the nerves during shoulder surgery. It aims to improve pain control after the operation.
ProvidenciaAges 18 years+ - NCT06930027Enrolling by invitation
Low-oxygen training for ice hockey players
This study tests whether training in a low-oxygen environment (hypoxia) can boost strength and power in ice hockey players. Researchers want to see if it helps improve your explosive movements and muscle function.
Katowice, Silesian VoivodeshipAges 18–35 - NCT06887608Enrolling by invitation
Partner-Assisted Rebozo for Birth Comfort
This study tests a partner-assisted rebozo technique — a gentle way to help ease pain and fear during labor. Your partner wraps a scarf around your belly and sways it rhythmically, with guidance from a nurse, to make you more comfortable.
Zeytinburnu, IstanbulAges 18 years+ - NCT06935201Recruiting
Digital rehab program for spinal stenosis surgery recovery
This study tests a digital, person-centered rehab program to help people recovering from surgery for lumbar spinal stenosis become more physically active. It aims to see if an online program can improve recovery and quality of life after surgery.
StockholmAges 18 years+ - NCT07336303Recruiting
Ear acupuncture for thumb surgery pain
This study tests whether ear acupuncture (auriculotherapy) helps reduce pain after thumb arthritis surgery. If you're having this surgery and haven't tried ear acupuncture before, you may be able to join.
ParisAges 18 years+ - NCT07333560Recruiting
Predicting recovery after hip or knee replacement
This study is developing a tool that uses machine learning to predict how well you will recover after hip or knee replacement surgery. It aims to help doctors create better recovery plans for people like you.
BolognaAges 18 years+ - NCT07326644Recruiting
How Weight Gain Affects Spinal Anesthesia in Planned C-Section
This study looks at how weight gain during pregnancy affects spinal anesthesia during a planned C-section. It may help doctors understand if weight gain influences the numbing effect of the spinal block.
Elâzığ, ElaziğAges 18–45 - NCT07345962Recruiting
Pregnant patients' hopes and fears about walking epidural
This study asks pregnant women at the CMCO about their hopes and concerns regarding walking epidural (pain relief during labor that allows you to move). It aims to understand what patients think and feel about this option.
StrasbourgAges 18 years+ - NCT06790537RecruitingPhase 4
Pregabalin for itching in diabetes: a controlled study
This trial tests if pregabalin can reduce chronic itching in people with type 2 diabetes. It compares pregabalin against a placebo (inactive pill) to see if itching improves more with the active drug.
Chandigarh, ChandigarhAges 18 years+ - NCT07329361Recruiting
Frozen platelet-rich plasma injections for knee osteoarthritis
This trial tests whether frozen platelet-rich plasma (PRP) injections into the knee can safely reduce pain and improve function in people with knee osteoarthritis. It's for those with mild to moderate knee arthritis who haven't had certain recent knee treatments.
Vitoria-Gasteiz, Araba/ÁlavaAges 40–85 - NCT06841601Recruiting
Shaking or cold for less pain during dental shots
This trial tests whether a vibrating tool or a cold pack can help reduce pain when children get a numbing shot at the dentist. If your child needs a simple filling and is generally healthy, this study might help make their experience more comfortable.
AlexandriaAges 5–9 - NCT07363941Recruiting
Comparing height-based vs standard spinal anesthesia dosing for older adults
This study compares two ways of giving spinal anesthesia (numbing medication in the back) for older adults having leg or hip surgery. It aims to see if adjusting the dose based on height works better than the standard fixed dose. If you are between 60 and 80 and having planned lower limb surgery, you may be eligible.
Karachi, SindhAges 60–80 - NCT06491121Recruiting
Can high-intensity training with a smartphone help chronic back pain?
This trial tests if a technology-supported high-intensity exercise program can help adults with chronic low back pain. You'll use your own smartphone to help guide the training and attend regular therapy sessions.
Wilrijk, AntwerpenAges 18–65 - NCT06359665Enrolling by invitationPhase 1
Oral curcumin for thumb arthritis pain
This trial tests whether an oral curcumin supplement can help reduce pain from thumb arthritis. If you are an adult with daily thumb pain of at least moderate severity and have not taken turmeric or blood thinners, this may be an option for you.
Charlottesville, VirginiaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.