Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07295184Recruiting
Rebound pain and confusion after hip surgery
This study looks at a way to reduce confusion after hip surgery. If you are having planned hip surgery and get a nerve block for pain, researchers will check if rebound pain affects your recovery in the hospital.
Konya, KaratayAges 18–80 - NCT06568198RecruitingPhase 2
Brain stimulation study for chronic low back pain
This trial tests whether a noninvasive brain stimulation technique called tACS can help reduce chronic low back pain. Participants will have brain scans and receive the treatment over several sessions.
Charlestown, MassachusettsAges 18–60 - NCT07396077Recruiting
Pre-op health boost for elderly spine surgery patients
This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.
Beijing, Beijing MunicipalityAges 75 years+ - NCT06564857RecruitingPhase 4
Comparing two drugs for easier breathing tube placement
This trial compares two medicines—remifentanil and rocuronium—to see which helps doctors place a breathing tube more easily during anesthesia. It may help you if you are having routine surgery and need a tube for breathing support.
CopenhagenAges 18 years+ - NCT05985148RecruitingPhase 1
Radiosurgery for chronic chest or stomach wall pain
This trial tests whether a precise, one-time radiation treatment (stereotactic radiosurgery) can relieve long-term pain in the chest or stomach wall. It may be an option for people whose pain is not well controlled with standard pain medicines.
Basking Ridge, New JerseyAges 18 years+ - NCT06557044Recruiting
Numbing shot for pain after hip replacement
This study tests if a special numbing shot around the hip joint (PENG block) gives better pain relief after hip replacement. It compares this shot plus standard pain medicine to standard medicine alone.
Stuttgart, Baden-WurttembergAges 18 years+ - NCT07662408RecruitingPhase 4
Comparing two drugs to prevent low blood pressure during hip surgery
This trial tests two different medicines (norepinephrine and phenylephrine) given as an infusion to prevent low blood pressure after spinal anesthesia for hip surgery. It may help older adults undergoing planned hip replacement or repair.
SohagAges 60–100 - NCT06556771Recruiting
Comparing two mobilization techniques for neck pain relief
This study compares two hands-on therapy methods (Gongs and Kaltenborn mobilization) to see which one works better for reducing mechanical neck pain. If you have neck pain that gets worse with movement or sitting still, this trial may help find a more effective treatment for you.
Attock City, Punjab ProvinceAges 18–65 - NCT06989372Enrolling by invitation
Nerve blocks for pain relief after chest surgery
This study compares two different nerve block methods to see which provides better pain control. If you qualify, you may receive one of these blocks before your chest surgery.
CairoAges 18–65 - NCT06534775Recruiting
Chronic pain after sternotomy follow-up study
This study checks if chronic pain after sternotomy changes over time. If you were in the original PABLOS study, you may be able to join this follow-up.
Angers, Maine Et LoireAges 18 years+ - NCT07281885Recruiting
Aromatherapy for nausea after joint replacement
This study tests whether aromatherapy with essential oils can help reduce nausea and vomiting after total joint replacement surgery. Participants will receive a simple aromatherapy treatment alongside their regular care.
Wong Tai Sin, Hong KongAges 18 years+ - NCT06527183Recruiting
Fibromyalgia and small fiber nerve study
This study looks at whether people with fibromyalgia or long-term chronic pain have damage to the small nerve fibers in their skin. Understanding this could help develop better treatments.
Boulogne-BillancourtAges 18 years+ - NCT06520631Recruiting
Cryotherapy for pain from dialysis needle insertion
This study tests if applying cold therapy (cryotherapy) to the access site before needle insertion can reduce pain during hemodialysis. If you are on dialysis and have an arteriovenous fistula, this might help make your treatment more comfortable.
CairoAges 30–50 - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT06509087Recruiting
Combining CT and MRI for joint pain procedure
This study tests a procedure called transarterial microembolization for chronic shoulder or knee pain that hasn't improved with other treatments. It uses both CT and MRI to guide the procedure and see if it can help reduce pain.
TaipeiAges 20–80 - NCT06511401Recruiting
Pain treatment guided by your genes
This study looks at whether knowing your genetic makeup can help doctors choose the safest and most effective pain medicine for you before you start taking opioids. If you are being treated for cancer and may need opioid pain medication soon, this trial might be a fit.
Chicago, IllinoisAges 18 years+ - NCT06507527Recruiting
Frailty in older adults having outpatient digestive endoscopy
This study looks at frailty in older adults (70+) who are having an outpatient digestive endoscopy. It aims to understand how frailty affects the procedure and recovery.
BarcelonaAges 70–100 - NCT07404982RecruitingPhase 2
Speeding Recovery from Spinal Anesthesia After Joint Surgery
This trial tests a way to make the leg numbness and weakness from spinal anesthesia wear off faster after joint replacement surgery. Researchers use a small tube (catheter) placed in your spine during the procedure to reverse the muscle block sooner.
Boston, MassachusettsAges Any age - NCT06491082Recruiting
Chemotherapy nerve damage study in solid tumor patients
This study looks at nerve damage (neuropathy) that can happen as a side effect of chemotherapy. It aims to understand how common it is and how it affects people being treated for solid tumors.
DehradunAges 18 years+ - NCT02821741Recruiting
Testing ear stimulation effects on pain and mood
This study tests whether stimulating the outside of your ear changes how you feel pain and how your mood/feelings are measured. It’s mainly testing a non-drug, ear-based approach and whether it affects pain signals.
Bethesda, MarylandAges 18–50 - NCT06487936Recruiting
Patient satisfaction study for SI joint fusion device
This study looks at how satisfied people are after getting the TransLoc 3D SI Joint Fusion System. It is a registry study, meaning it simply collects information from patients who already have the device to see how well it works for them.
Port Charlotte, FloridaAges 18 years+ - NCT07694882Recruiting
Gentle pressure techniques for chronic neck pain
This study tests two different types of gentle pressure techniques (myofascial release) to see which one helps relieve long-term neck pain and improve everyday function. It is for people with chronic neck pain that isn't caused by a specific injury or disease.
Famagusta, HatayAges 18–45 - NCT06485856Recruiting
Pain tracking using facial movements for non-verbal patients
This trial tests a system that measures facial movements to assess pain in patients who cannot speak or communicate verbally, such as those with a breathing tube. It may help healthcare providers better understand and manage pain in these patients.
AdanaAges 18 years+ - NCT07461376Recruiting
A trial comparing two sleep medicines for children before surgery
This study tests two oral medicines given before surgery to help children relax and lower the need for stronger painkillers after the operation. It is for children having surgeries like hernia repair, circumcision, or hypospadias correction.
Cairo, Giza GovernorateAges 3–12
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.