Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07709416Recruiting
Testing toludesvenlafaxine for long-lasting low back pain
This study tests an experimental medication called toludesvenlafaxine to see if it can help people with long-lasting low back pain that has no clear cause. If you have moderate to severe lower back pain for more than 3 months and haven't taken antidepressants before, this may be an option for you to explore.
BeijingAges 18–75 - NCT06654635Recruiting
Ultrasound-guided nerve blocks for upper abdominal surgery
This trial compares two types of nerve blocks to control pain after upper abdominal surgery. One block targets the rhomboid intercostal area, and the other targets the erector spinae muscle. This could help reduce pain and improve recovery.
Tanta, El-GharbiaAges 21–65 - NCT06646172Recruiting
Long-acting pain medicine during heart surgery
This trial tests a long-acting numbing medicine (liposomal bupivacaine) compared to standard local anesthetic during heart surgery through the breastbone. It aims to provide better pain control with fewer side effects.
Wuhan, HubeiAges 18–90 - NCT06642142Recruiting
When numbness starts after a spine block for breast surgery
This study is testing how quickly numbness starts after a specific type of pain block (erector spinae plane block) given before breast surgery. It may help people who are having breast surgery and are healthy enough to receive this block.
Latina, ItalyAges 18 years+ - NCT07366138Recruiting
Nerve blocks for pain after sleeve gastrectomy surgery
This trial compares two ultrasound-guided nerve blocks to manage pain after laparoscopic sleeve gastrectomy. If you are having this weight-loss surgery, these blocks might help reduce your need for pain medicine and improve your recovery.
Banhā, BenhaAges 18–65 - NCT06633068RecruitingPhase 2
Pain relief study: nalbuphine added to numbing medicine for thyroid surgery
This study tests if adding nalbuphine to the numbing medicine (bupivacaine) given as a nerve block before thyroid surgery provides better pain relief. It is for adults having planned thyroid surgery.
Giza, الجيزةAges 18–60 - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT06820190Recruiting
Numbing injection for pain after scoliosis fusion surgery
This trial is testing a new type of numbing injection near the spine to see how well it controls pain after scoliosis surgery. If you are having a posterior spinal fusion for idiopathic scoliosis, you may be able to join and receive the injection plus patient-controlled pain medicine.
Tanta, El-GharbiaAges 18 years+ - NCT07375914Recruiting
New approach for managing acute low back pain in the ER
This trial tests a comprehensive program that looks at your physical, mental, and social needs to treat sudden low back pain in the emergency room. It may help you get better care and avoid long-term pain.
ParisAges 18–55 - NCT07445659Recruiting
Brain-guided anesthesia for thyroid surgery
This study is testing a new type of brain-activity monitoring during thyroid surgery. It uses special stickers on your head to help guide the anesthesia, which may lead to a smoother recovery.
Kayseri, KayseriAges 18–70 - NCT05963451Recruiting
Testing treatments for long-term low back pain from facet joints
This study focuses on people with long-lasting low back pain that likely comes from the small “facet” joints in the lower spine. It aims to better understand brain, psychological, and biology changes to help optimize treatment for this type of back pain.
Sherbrooke, QuebecAges 18–75 - NCT06603051Recruiting
Freezing a nerve before ACL surgery to cut opioid use
This study looks at freezing a nerve before ACL surgery to help reduce the amount of strong pain medicine you need afterward. If you're having ACL reconstruction with your own tendon and haven't been using opioids regularly, you may be able to join.
Burlington, New JerseyAges 14 years+ - NCT06602349Recruiting
Lidocaine injection for chronic anal/perineal pain
This trial tests whether injecting a numbing medicine (lidocaine) into the painful area helps people with chronic, unexplained pain in the anal or perineal region. It is for patients who have not gotten relief from standard treatments and whose MRI shows no other cause.
Paris, Île-de-France RegionAges 18 years+ - NCT06604364Recruiting
Virtual reality to reduce anxiety before children's arm or leg surgery
This study tests whether watching a virtual reality video can help calm children aged 7 to 12 before minor orthopedic surgery. If your child is having a short procedure (less than an hour) with a numbing shot instead of full sleep medicine, this might be a good fit.
BolognaAges 7–12 - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT05968313Recruiting
Brain scan study of pain feelings in teens who self-harm
This study uses brain activity during a task to understand how teens who self-harm react to pain and empathy. It may help researchers learn what brain differences are linked with non-suicidal self-injury and guide better support for teens.
Chengdu, SichuanAges 15–18 - NCT06600685Enrolling by invitation
Music therapy for long-term pain
This study tests whether a special type of music therapy (called FMT) can help reduce long-term pain in muscles and bones. If you have had pain for at least 3 months and can speak Swedish or English, this may be an option for you.
Eskilstuna, EskilstunaAges 18 years+ - NCT05970783RecruitingPhase 3
Jincaopian tablets for ongoing pelvic pain after pelvic infection
This trial tests whether Jincaopian tablets can reduce long-lasting pelvic pain that happened after pelvic inflammatory disease. You may be able to join if your pain is still moderate to severe and other causes of pelvic pain have been ruled out.
Beijing, Beijing MunicipalityAges 18–50 - NCT07405060Recruiting
How age and muscle fatigue affect balance and control
This study looks at how getting older and muscle tiredness change your ability to keep your balance and control your movements. It may help explain why some people are more likely to fall.
TaoyuanAges 20–85 - NCT07453004RecruitingPhase 2
Study of plonmarlimab for frequent gout attacks
This trial tests a new investigational drug called plonmarlimab for people with frequent, painful gout flares who cannot take standard treatments. The goal is to see if it can reduce pain and inflammation from the flare.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06590402RecruitingPhase 4
Nerve blocks for pain relief after kids' knee surgery
This study compares two types of nerve blocks to manage pain after knee surgery in children and teens. It is for patients aged 8 to 18 having a first-time ACL or MPFL reconstruction.
New York, New YorkAges 8–18 - NCT06589557Enrolling by invitation
VR therapy for neck disc disease
This study tests a new VR therapy to help people with neck pain caused by cervical disc disease. It aims to improve movement and reduce pain without surgery.
Rzeszów, Al. Rejtana 16CAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.