Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT05789173RecruitingEarly Phase 1
Testing how genetics affect drug levels with methadone
This early study tests how a person’s genetic makeup may change how fast certain medicines move through the body. It compares drug levels when combined with methadone and tizanidine, aiming to understand safer dosing and effects.
Indianapolis, IndianaAges 18–65 - NCT06168058Recruiting
Pelvic vein embolization for chronic pelvic pain
This trial tests if blocking enlarged veins in the pelvis (called embolization) can reduce long-term pelvic pain that hasn't improved with other treatments. It may help women whose pain is worse when standing or walking and better when lying down.
New Hyde Park, New YorkAges 18–75 - NCT05081596Recruiting
Primary care program for mood and thinking in early Alzheimer’s
This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.
White Plains, New YorkAges 60 years+ - NCT07227077Recruiting
Physical activity study for older cancer survivors with chronic pain
This study uses a smartphone program to encourage physical activity in older adults who have survived cancer and have ongoing pain. It aims to learn how to best help you move more and feel better.
Milwaukee, WisconsinAges 65 years+ - NCT06619418Recruiting
Home Device Using Sound and Body Stimulation for Back Pain
This study is testing a take-home device that uses sound and gentle body stimulation to help with long-term back pain. It is for adults with chronic low back pain who live near the University of Minnesota and are not taking certain sleep or anxiety medications.
Minneapolis, MinnesotaAges 18 years+ - NCT07260864Recruiting
rTMS for fibromyalgia pain
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce pain in people with fibromyalgia. If you join, you'll receive rTMS sessions and we'll monitor your brain activity to see how it affects your pain.
Rochester, New YorkAges 18–65 - NCT07771205Recruiting
Aromatherapy for surgical anxiety and pain
This study tests whether breathing in relaxing scents before surgery can reduce anxiety and pain. If effective, it could offer a simple, drug-free way to help you feel calmer during your procedure.
Stockton, CaliforniaAges 18 years+ - NCT07464093Recruiting
Pilates for joint hypermobility pain
This trial tests if a special Pilates program can reduce pain in people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. You must have had pain for at least 3 months and be able to get on and off the floor on your own.
Chestnut Hill, MassachusettsAges 18 years+ - NCT07641504RecruitingPhase 2
Testing LY4065967 for chronic low back pain relief
This study tests whether a new medication called LY4065967 can reduce chronic low back pain. Researchers want to see if it works better than current treatments for people who have had lower back pain for at least 3 months.
Birmingham, AlabamaAges 18 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT06859801Recruiting
Bone pain study combining ablation and radiation
This study looks at combining two treatments for painful bone tumors that have spread from other cancers. It tests if using both treatments together provides better pain relief than either alone.
San Diego, CaliforniaAges 21 years+ - NCT07341854Recruiting
Dexamethasone shot for pain after surgery
This study tests a special form of dexamethasone (a steroid) given as a shot before surgery to help control pain after the operation. It may reduce the need for other pain medicines and make recovery more comfortable.
Beijing, ChinaAges 18–65 - NCT07315334Recruiting
Understanding nerve damage from chemotherapy
This study looks at how chemotherapy-related nerve damage affects daily activities like walking and standing. It includes people who currently have or have had nerve-damaging chemotherapy and are experiencing nerve pain or weakness.
SalzburgAges 18 years+ - NCT07764666Enrolling by invitation
Cooling rinse for molar pain after root canal treatment
This study tests whether using a chilled saline rinse during a root canal treatment can reduce pain after the procedure. It compares two standard rinses, with and without cooling, to see which is more comfortable.
Cairo, Cairo GovernorateAges 15–40 - NCT07650591Recruiting
Tapping and vibration to ease needle pain in children
This study tests whether rhythmic tapping and gentle vibration near the skin can help children ages 6–12 feel less pain and fear during blood draws. Researchers want to see if these simple techniques can make the procedure more comfortable.
Antalya, KepezAges 6–12 - NCT05790239RecruitingPhase 2
MDMA therapy sessions for veterans with PTSD
This Phase 2 trial tests whether therapy assisted by MDMA can reduce symptoms of moderate to severe post-traumatic stress disorder (PTSD) in eligible veterans. It includes supervised therapy sessions and extra study visits with video recording to track changes over time.
Los Angeles, CaliforniaAges 18 years+ - NCT07498140Recruiting
Epidural steroid injection for leg and back pain
This study is testing a treatment that involves an injection to reduce nerve-related leg and back pain. It looks at how much information about the procedure affects a patient's outlook and pain relief.
Chicago, IllinoisAges Any age - NCT07770932Recruiting
Pain relief after hip replacement surgery
This study compares two types of nerve blocks for pain relief after hip replacement surgery. It aims to find which method reduces pain and improves recovery.
Istanbul, BagcilarAges 18–80 - NCT07769619Recruiting
AI and brain scans for chronic pain in rheumatoid arthritis
This study uses AI, brain scans, and blood tests to understand chronic pain in rheumatoid arthritis (RA). It may help find better ways to treat pain in the future.
WroclawAges 18 years+ - NCT05541276RecruitingPhase 3
Melatonin to prevent waking confusion in young children after surgery
This study tests whether giving melatonin before surgery can help prevent agitation and confusion in young children after they wake up from anesthesia. Participation may help your child have a smoother recovery after their procedure.
Copenhagen, Capital RegionAges 1–6 - NCT06401317RecruitingPhase 2
Steroid vs saline injections for thumb arthritis pain
This study compares two types of injections for thumb arthritis pain: a steroid (cortisone) and salt water (saline). We want to see if the steroid provides better pain relief than the salt water.
Montreal, QuebecAges 18 years+ - NCT06621329RecruitingPhase 2/Phase 3
Numbing shot for headache after brain bleed
This trial tests a numbing injection inside the nose to quickly relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). It may help reduce pain without strong medicines.
Sacramento, CaliforniaAges 18–100 - NCT07465185RecruitingPhase 2
Testing a drug for cesarean delivery pain relief
This study compares a standard spinal anesthetic (bupivacaine) with or without an added drug (dexmedetomidine) to see which works better for pain relief during planned cesarean delivery. It may help find a safer or more effective option for mothers.
Banhā, Elqalyoubea,Ages 20–35
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.