Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT05317026Recruiting
Test adding cement injection to SBRT for spine pain
This study tests whether adding a vertebroplasty procedure (a cement injection to stabilize a spine bone) to standard SBRT radiation can reduce pain from spinal metastases. It may help people with painful, possibly unstable spine lesions by improving early pain relief.
Montreal, QuebecAges 18 years+ - NCT07311889Enrolling by invitation
Patient satisfaction with ELIXIR MD during plastic surgery recovery
This study looks at how satisfied patients are with their recovery after plastic surgery when the ELIXIR MD device is used. It aims to understand if this device helps improve the recovery experience.
Irvine, CaliforniaAges 18 years+ - NCT07776600Recruiting
Pain coaching by text or phone for veterans
This study tests a text or phone chatbot that offers pain coaching to veterans with chronic pain. It may help you manage your pain and avoid extra clinic visits.
Augusta, GeorgiaAges 18 years+ - NCT07777081Recruiting
How your brain and body recover after a wrist fracture
This study looks at how your brain and body heal after a wrist fracture. By joining, you'll help doctors understand recovery better, which could improve care for future patients.
Cambridge, CambridgeshireAges 18 years+ - NCT07710352Recruiting
Comparing gas pressure settings for robotic surgery
This study compares two different gas pressure levels used during robotic surgery to see if one is better for patients. If you are having robotic surgery, it may help doctors improve safety and recovery.
New York, New YorkAges 18 years+ - NCT07406997Recruiting
Back surgery recovery program
This trial tests a program to help people recover better after back surgery for conditions like spinal stenosis or sciatica. It may help you get back to daily activities faster.
Honolulu, HawaiiAges 18–85 - NCT07777627Recruiting
Comparing two spinal pain relievers after lumbar spine surgery
This trial compares two different medications (morphine and dexmedetomidine) given through a spinal injection to see which provides better pain relief after lumbar spine surgery. If you qualify, you will receive one of these treatments or a placebo to help manage your pain after the operation.
Tanta, El-GharbiaAges 21–60 - NCT07779486Recruiting
Intravenous magnesium for acute headache pain relief
This study compares two doses of intravenous (IV) magnesium to see which is more effective at relieving acute headache pain in the emergency department. It aims to provide a fast and effective treatment option for migraine, tension-type, or cluster headaches.
MonastirAges 18 years+ - NCT07210515RecruitingPhase 3
Testing Ambros Therapy for Early CRPS
This trial tests if an intravenous medicine called AMBTX-01 (neridronate) can help people with early-stage Complex Regional Pain Syndrome (CRPS) type 1. It focuses on those whose affected limb feels warm, looks red, and is swollen.
Phoenix, ArizonaAges 18 years+ - NCT07018700RecruitingPhase 3
Study on Xeomin shots to prevent migraines
This trial tests if Xeomin injections can help prevent episodic migraines in people who have 6 to 14 migraine days per month. It's for those under 50 when their migraines started and who can tell migraine from other headaches.
Chandler, ArizonaAges 18 years+ - NCT07778069Enrolling by invitation
Virtual reality for children having joint steroid injections
This study tests whether using virtual reality (VR) during a steroid joint injection helps children feel less pain and anxiety. If it works, it could make the procedure easier for patients from 5 to 17 years old.
Columbus, OhioAges 5–17 - NCT07018713RecruitingPhase 3
Testing Xeomin injections to prevent chronic migraine
This trial tests if Xeomin (a botulinum toxin injection) can help prevent chronic migraine. If you have frequent migraine headaches, you may be able to join.
Chandler, ArizonaAges 18 years+ - NCT07542730RecruitingPhase 4
Diphenhydramine to ease discomfort during early abortion procedure
This study tests whether adding diphenhydramine (a common allergy medicine) to sedation helps patients feel more comfortable during a procedural abortion in the first trimester. Researchers want to see if it improves pain control and overall experience.
Rochester, New YorkAges 18 years+ - NCT06870162Recruiting
Pain disengagement training: a writing study for chronic pain
This study tests a writing-based program to help people with chronic pain learn to disengage from pain-related thoughts. It aims to reduce pain catastrophizing and improve daily function.
Boston, MassachusettsAges 18 years+ - NCT06579274RecruitingPhase 2
Parecoxib for pain after bleeding stroke study
This trial tests a pain medicine called parecoxib (injected into a vein) for people who have had a bleeding stroke around the brain (subarachnoid hemorrhage). It aims to see if it helps with pain without causing serious side effects.
Brno, Czech RepublicAges 18–85 - NCT07779551Enrolling by invitation
Pain relief after thyroid surgery: comparing two numbing drugs
This study compares two medications, bupivacaine and ropivacaine, given as a neck block before thyroid surgery to see which provides better pain relief after the operation. It may help reduce post-surgery discomfort.
Sargodha, Punjab ProvinceAges 20–40 - NCT07639060Recruiting
Pain Relief Study Using Freezing Nerve Treatment
This study watches how well a freezing procedure works for chronic pain over 6 to 12 months. Your doctor thinks this procedure could help your pain, and the study simply tracks your recovery through questionnaires to help doctors understand if it works.
Old Saybrook, ConnecticutAges 18 years+ - NCT06975072RecruitingPhase 4
Can magnesium affect nerve monitoring during back surgery?
This study tests if giving magnesium during open thoracolumbar fusion surgery (a type of back surgery) affects nerve monitoring. It might help find the right dose for patients while keeping their nerves safe.
San Francisco, CaliforniaAges 18 years+ - NCT07221617RecruitingPhase 4
Methadone for pain after heart surgery
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
Rochester, MinnesotaAges 18 years+ - NCT05897320RecruitingPhase 3
Eptinezumab trial for kids with episodic migraine
This Phase 3 study tests eptinezumab to reduce migraine attacks in children who have episodic migraine (not daily chronic migraine). It may help by lowering the number of headache days and migraine days over time. You must complete a headache diary during screening to be considered.
Stamford, ConnecticutAges 6–17 - NCT07718217Recruiting
Mindfulness education for women with PCOS
This study tests whether a 4-week online mindfulness program can help women with PCOS manage stress and improve well-being. You'll attend group sessions and complete surveys from home.
BursaAges 18–49 - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Phoenix, ArizonaAges birth–20 years - NCT04824248Recruiting
Weight-loss program for chronic low back pain
This trial studies whether weight loss can improve long-lasting, non-specific low back pain. It may help people whose back pain is partly related to extra weight by testing a structured approach over time.
BrusselsAges 18–65 - NCT07775053Enrolling by invitation
Pain relief study for breast cancer surgery
This study tests whether adding tramadol to a standard numbing medicine (ropivacaine) makes pain control better after breast cancer surgery. If you're having a mastectomy, this could help reduce pain and improve recovery.
Sargodha, Punjab ProvinceAges 20–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.