Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07386327Recruiting
Comparing diluted bupivacaine for arm surgery nerve block
This trial tests whether mixing the numbing medicine bupivacaine with sugar water (dextrose) or salt water (saline) affects how well a nerve block works for upper arm surgery. The goal is to find which mixture provides better pain relief with fewer side effects.
SakaryaAges 18–65 - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65 - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT06098586Recruiting
Nerve surgery vs exercise for wrist arthritis
This study compares two treatments for wrist arthritis: a surgery that cuts certain wrist nerves to stop pain signals, versus structured hand exercises. It may help if you have chronic wrist pain from a specific type of arthritis and haven't had previous wrist nerve surgery.
MalmöAges 18 years+ - NCT06837298Recruiting
Fava bean extract supplement for muscle recovery
This trial tests whether a supplement made from fava bean protein can help your muscles recover strength after exercise. You would take the supplement for about 2 weeks and have your muscle function tested before and after.
Bradenton, FloridaAges 18–45 - NCT06492213Recruiting
Combining PRP with Radiofrequency for Face Nerve Pain
This study tests whether adding platelet-rich plasma (a concentrate from your own blood that may help healing) to a standard pulsed radiofrequency procedure reduces pain from infraorbital neuralgia more effectively than radiofrequency alone. It involves two treatments and follow-up for several months.
Beijing, Beijing MunicipalityAges 18–75 - NCT06261801Recruiting
Acupuncture plus pregabalin for shingles pain on the face
This trial tests whether adding acupuncture (electroacupuncture) to the standard pain medicine pregabalin can better relieve facial shingles pain that started 1 to 3 months ago. It's for people with moderate pain who are willing to try both treatments together.
Hangzhou, ZhejiangAges 18–85 - NCT06598644Recruiting
Comparing two gentle neck pain treatments
This study tests two hands-on treatments for long-lasting neck pain: a gentle gliding movement called Sustained Natural Apophyseal Glide (SNAG) and a soft-tissue release technique called Instrument Assisted Soft Tissue Mobilization (IASTM). If you have had neck pain for more than 3 months, this trial may help find which method works better for you.
Rawalpindi, Punjab ProvinceAges 20–45 - NCT06707805Recruiting
Spinal gliding technique for lower cross syndrome
This trial tests a manual therapy technique called sustained natural apophyseal glides (gentle, sustained pressure on the spine) in people with low back pain caused by lower cross syndrome—a pattern where hip flexors and lower back muscles are tight while abs and buttock muscles are weak. If you have lower back pain with a forward-tilted pelvis and meet the age and muscle tightness/weakness criteria, this study may be for you.
Kotli, Azad KashmirAges 30–50 - NCT06584721Recruiting
Foot exercises and taping for low back pain with flat feet
This study tests whether simple foot exercises combined with special tape on the foot can reduce low back pain in people whose feet roll inward too much (a condition called hyper-pronation). It may help if you have had back pain for months and also have flat feet.
Wāh, Punjab ProvinceAges 25–45 - NCT06839690Recruiting
Comparing two exercises for De Quervain tenosynovitis
This study compares two types of exercises (sub-maximal isometric training vs eccentric training) to see which one helps more with thumb pain and tenderness caused by De Quervain tenosynovitis. You may qualify if you have had thumb pain for at least 3 weeks and meet certain diagnostic tests.
Rawalpindi, Punjab ProvinceAges 21–50 - NCT06842329Recruiting
Can distraction ease injection pain for teens with period pain?
This study tests whether using simple distraction techniques during a shot can reduce pain in teenage girls who come to the emergency room with severe menstrual cramps.
SamsunAges 12–18 - NCT07372430Recruiting
Nerve block comparison for buttock nerve pain
This study compares two ways of giving a numbing injection (nerve block) to treat a condition where a nerve in the low back gets pinched, causing long-term buttock or low back pain. It aims to see which method works better.
IstanbulAges 18–75 - NCT06351839Recruiting
Sleep better despite long-term pain
This trial tests a program to help people with chronic pain and insomnia sleep better. It focuses on combining pain management with sleep improvement strategies.
Tromsø, Troms CountyAges 18–75 - NCT07372547Recruiting
Does Shower Standing Help Women Empty Bladder After Catheter Removal?
This trial compares standing in the shower versus sitting on a toilet to see which position helps women empty their bladder more completely after a urinary catheter is removed following vaginal surgery.
AshdodAges 18–99 - NCT07375576Recruiting
Comparing partial nerve removal to root canal for severe tooth pain
This study compares two ways to treat severe tooth pain from advanced decay: a partial nerve removal (pulpotomy) versus a full root canal treatment. It aims to find which approach works better for saving the tooth.
Hatay, AntakyaAges 18–45 - NCT07378215RecruitingPhase 4
Steroids for better recovery after hip replacement
This study tests whether a single dose of steroids (dexamethasone) given during hip replacement surgery can improve your recovery and quality of life. It may help reduce pain and swelling after the procedure.
Genk, LimburgAges 60 years+ - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT07375914Recruiting
New approach for managing acute low back pain in the ER
This trial tests a comprehensive program that looks at your physical, mental, and social needs to treat sudden low back pain in the emergency room. It may help you get better care and avoid long-term pain.
ParisAges 18–55 - NCT07376915Recruiting
Mental imagery for ankle weakness: A pilot study
This study tests a new way of using mental imagery and gentle movements to help people with long-term ankle weakness. It may improve ankle stability without the need for surgery.
IstanbulAges 18–40 - NCT07377357Recruiting
Electrical stimulation for chronic back-related leg pain
This trial tests if a single session of electrical stimulation to the sciatic nerve can quickly reduce leg pain related to low back problems. It may help if you have had chronic sciatica (leg pain from your back) for more than 6 months and your pain has recently been interfering with daily life.
Madrid, MadridAges 18–70 - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT07374354Recruiting
Pain and anxiety control for kids with MIH
This study tests a pain-relieving medicine given before dental treatment to see if it helps reduce pain and anxiety in children with molar incisor hypomineralization (MIH), a condition that causes weak enamel on molars and front teeth.
GizaAges 6–12 - NCT07378046Recruiting
Baclofen for shingles pain: a safety and effectiveness study
This study tests whether the muscle relaxant baclofen can safely reduce shingles pain. It is for adults with moderate to severe pain who have not tried this drug before.
BeijingAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.