Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT03737292RecruitingPhase 4
Numbing medicine for chest surgery pain after small lung operations
This trial tests whether a long-lasting numbing shot (liposomal bupivacaine) works better than a regular numbing shot (plain bupivacaine) for pain after minimally invasive chest surgery. It may help you have less post-surgery pain and potentially use less pain medication.
Hershey, PennsylvaniaAges 18 years+ - NCT03756961Recruiting
Opioid-free care plan for people having weight-loss surgery
This trial studies whether an opioid-free or opioid-sparing care pathway can improve comfort and outcomes for adults undergoing laparoscopic weight-loss surgery. It may help people avoid side effects from opioid pain medicines while still managing pain safely.
Lindesberg, Region ÖrebroAges 18 years+ - NCT03781492Recruiting
Treatment study for stable angina symptoms
This study looks at managing and treating stable angina, a type of chest discomfort that happens predictably with activity or stress. It may help find better ways to control symptoms and improve daily life, but you must not have certain recent heart events to join.
Zabrze, Silesian VoivodeshipAges 18 years+ - NCT03789552RecruitingPhase 3
Testing T89 to prevent chest pain during stable angina
This Phase 3 trial tests whether T89 reduces angina (chest pain caused by heart-related reduced blood flow) in people with stable angina. You may help confirm the treatment’s benefit by completing symptom tracking and exercise heart tests over several weeks.
Naples, FloridaAges 18–90 - NCT03794362Recruiting
Testing how pain medicines change pupils in children
This study looks at how different pain treatments affect a child’s pupils (the dark center of the eye). It may help doctors better understand which pain medicines are working and how to measure pain treatment effects more accurately.
Washington D.C., District of ColumbiaAges 7–21 - NCT03794466Recruiting
Study pain relief after blocking gonadal veins for pelvic congestion
This study looks at how much pelvic pain improves after a procedure called gonadal vein embolization (blocking problem veins). It mainly applies to people diagnosed with pelvic congestion syndrome caused by venous (vein) problems, treated during a specific time window.
Kansas City, KansasAges 18 years+ - NCT03796572RecruitingPhase 4
Nerve-block pain relief after a specific elbow bone fracture
This trial studies whether a pain-relief “nerve block” with medicine helps control pain after surgery for a particular type of elbow (humerus) fracture. It may help you feel more comfortable during recovery, compared with standard pain control.
Los Angeles, CaliforniaAges 4–12 - NCT03819062Recruiting
Stomach–bowel nerve stimulation for long-term constipation
This trial studies a device that stimulates nerves near the lower back (sacrum) to improve bowel function in people with severe constipation that hasn’t responded to standard treatments. It may help if your constipation involves problems coordinating bowel movement and the muscles around the rectum.
Hamilton, OntarioAges 6–70 - NCT03819738Recruiting
Brain scan during deep brain stimulation
This study checks how brain imaging works in people who already have a deep brain stimulation (DBS) device. If you have a DBS system, the study may help researchers better understand what the stimulation is doing in the brain.
Leuven, Vlaams-BrabantAges 18 years+ - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT03829631Recruiting
Test of a back brace for non-dangerous low back pain in ER
This trial studies whether using a lumbar brace in the emergency department helps people with non-serious low back pain recover better. You may be asked to try the brace when you come to the ER for back pain that is not caused by a dangerous underlying condition.
PerthAges 18–65 - NCT03834818Recruiting
Using a phone app to track pain after orthopedic surgery
This study collects information about pain and recovery after planned (elective) orthopedic surgery. It uses a smartphone to help understand outcomes and pain levels so care may improve.
Durham, North CarolinaAges 18–90 - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03852381Recruiting
Spinal cord stimulation for nerve pain after back surgery
This study looks at how spinal cord stimulation (a device that sends mild signals to the spinal cord) affects nerve pain after lumbar surgery. It also aims to help predict who is most likely to improve and why, comparing patients with and without certain sensory symptoms.
Toronto, OntarioAges 18–80 - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT03862365Recruiting
Study genetics in people with nerve pain
This study looks at genetic differences in people being checked for a common type of nerve problem called distal symmetric polyneuropathy (nerve damage that usually affects the hands and feet). By understanding genetics, researchers hope to learn more about why neuropathic (nerve) pain happens and how it may differ between people.
BergenAges 18–70 - NCT03862417Recruiting
Exercise program for adults with degenerative scoliosis pain
This pilot study tests an exercise program to help reduce pain and improve function in adults over 50 with degenerative scoliosis. It may be helpful if your spine curve is in a moderate range and you’re not recently had certain injections or surgery.
Edmonton, AlbertaAges 50 years+ - NCT03876054Recruiting
Tracking outcomes after Abbott neurostimulator implantation
This study follows people long-term after they get an Abbott device implanted to help with chronic pain. It aims to learn how well the therapy works in real-world care over time.
Phoenix, ArizonaAges 18 years+ - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT03906422Recruiting
Study of pain after placing braces archwire
This study compares how much pain people feel after their braces archwire is first put in. It may help orthodontists choose approaches that make the early pain experience easier.
Aurora, ColoradoAges 12 years+ - NCT03924791Recruiting
Epidural injection trial for acute sciatica pain
This study tests whether a specific back/nerve pain injection (an epidural injection) can help people with acute sciatica. You may qualify if your sciatica started a few weeks ago and your leg pain is still quite severe.
HaarlemAges 18 years+ - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT03984565RecruitingPhase 2
Study of a new cannabinoid for long-term body pain
This Phase 2 study tests how a new cannabinoid product affects people with ongoing musculoskeletal pain (like arthritis or injuries). It’s meant to see whether the product can improve pain for eligible adults who are not already using CBD regularly.
Belmont, MassachusettsAges 21 years+ - NCT03987334Recruiting
Virtual reality rehab for chronic neck pain
This trial studies whether virtual reality exercises can help reduce pain and improve function in people with chronic neck pain or whiplash. You may be invited to take part in guided VR rehab sessions if you meet the safety and health requirements.
Milan, MIAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.