Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07390279Recruiting
Radiofrequency treatment for shingles-related nerve pain
This study tests a safe, non-surgical treatment called transcutaneous pulsed radiofrequency to see if it can help reduce nerve pain that continues after shingles. It targets the painful area through pads on the skin.
Istanbul, IstanbulAges 18 years+ - NCT07396051Recruiting
Exercise program for frail older adults after back fusion surgery
This trial tests whether a special exercise program after lower back fusion surgery can help prevent complications in older adults who are frail. If you are 75 or older and having your first small back fusion, this rehab might help you recover better.
Beijing, Beijing MunicipalityAges 75 years+ - NCT06829875Recruiting
Access to muscle and joint therapy services
This study looks at how quickly people get appointments for muscle and joint problems. It includes patients waiting for foot therapy, occupational therapy, or physical therapy.
Cardiff, WalesAges 18 years+ - NCT06725862Recruiting
Pain relief methods for undescended testis surgery in children
This study compares two different numbing injections (caudal block vs retrolaminar block) given before surgery to see which one provides better pain control for children aged 1-7 undergoing undescended testis surgery.
IstanbulAges 1–7 - NCT06080997Recruiting
Patient expectations before spine surgery
This study looks at what patients expect before having spinal surgery. It may help improve how doctors support you before and after the operation.
Køge, Region SjællandAges 18–100 - NCT06832046Recruiting
Intranasal fentanyl for pain in pediatric emergencies
This study looks back at children who already received fentanyl nasal spray for pain in the emergency department. It aims to see how well this method worked for treating sudden pain in children.
StrasbourgAges 1–17 - NCT06832852Recruiting
Comparing cost-effective care for muscle and joint pain
This study compares different models of care to find the most cost-effective way to treat common muscle and joint problems (like back, neck, knee, or shoulder pain). It looks at which approach works best for patients with persistent pain to guide future treatment decisions.
Québec, QuebecAges 18–65 - NCT06101862Recruiting
CT scan vs. angiogram for certain heart attacks
This trial compares two ways to look at heart arteries: a CT scan (noninvasive) versus a traditional angiogram (a tube put into an artery). The goal is to see which is better for people having a certain type of heart attack.
Copenhagen, HellerupAges Any age - NCT06626958Recruiting
Stress ball for pain and comfort during labor
This trial tests if squeezing a stress ball during active labor can reduce pain and increase comfort for women having a vaginal birth. It may offer a simple, drug-free way to manage labor pain.
Muş, MerkezAges 18–40 - NCT06815393Recruiting
Comparing two pain relief methods for abdominal hysterectomy
This trial compares two different pain relief methods for women having abdominal hysterectomy (surgery to remove the uterus through a cut in the belly). It may help find a better way to manage pain after surgery.
Erzurum, YakutiyeAges 18–65 - NCT06819748Recruiting
Numbing medicine mix for less pain after gallbladder surgery
This trial tests a mixture of numbing medicines (ropivacaine cocktail) injected into the surgery area to reduce pain after gallbladder removal. It's for people having same-day laparoscopic surgery and aims to help you recover with less pain.
Chengdu, SichuanAges 18–70 - NCT06833749RecruitingPhase 2
Testing KBP-336 for knee osteoarthritis with obesity
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
BrnoAges 45 years+ - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65 - NCT07382973Recruiting
NTP safety in thyroid surgery: preventing complications
This trial is testing if a technology called NTP (a type of low-temperature plasma) can help prevent complications and improve cancer control when they remove all or part of the thyroid gland. It's for adults having thyroid surgery.
Ocoyoacac, State of MexicoAges 18 years+ - NCT07379866Recruiting
Nerve blocks for pain relief after tonsil removal in children
This trial tests if injecting numbing medicine near certain nerves in the head and neck can reduce pain after tonsil and adenoid surgery in children aged 5–13. It may help them recover more comfortably.
Cairo, GovernorateAges 5–13 - NCT07382830Recruiting
Visual feedback exercises after lower back surgery
This trial tests if a special exercise program that uses visual feedback helps people recover better after surgery for a herniated disc in the lower back. It may improve your recovery and reduce pain.
AntalyaAges 18–65 - NCT07388368Recruiting
Root canal pain study: comparing two tooth fillings
This study compares two types of fillings used after a root canal to see which one causes less pain afterward. If you have a tooth with severe, constant pain that needs a root canal, this trial may help find the best option for you.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07386327Recruiting
Comparing diluted bupivacaine for arm surgery nerve block
This trial tests whether mixing the numbing medicine bupivacaine with sugar water (dextrose) or salt water (saline) affects how well a nerve block works for upper arm surgery. The goal is to find which mixture provides better pain relief with fewer side effects.
SakaryaAges 18–65 - NCT07386353RecruitingPhase 4
Comparing two ways to give pain medicine after C-section
This trial tests two different ways of giving morphine for pain relief after a planned cesarean section: one is injected into the spinal fluid and the other into the space around the spinal cord. The goal is to see which method works better and is safer.
Funchal, MadeiraAges 18 years+ - NCT07382297Recruiting
Knee tumor pain study with extra nerve block
This study tests if adding an ultrasound-guided nerve block (IPACK) behind the knee to a standard nerve block (adductor canal block) can better control pain after knee tumor surgery. If you are having knee tumor removal and are in fair to poor health, this may help improve your recovery.
CairoAges 18–65 - NCT07386418Recruiting
Angina thresholds study for patients needing stent treatment
This trial is testing a new way to measure blood flow in the heart during exercise to better understand angina. You may be eligible if you have at least two blocked heart arteries and are scheduled for stent placement.
BasildonAges 18 years+ - NCT07388953Recruiting
Nerve block for better pain relief after colon surgery
This study tests adding a special nerve block (peripheral autonomic block) to a standard abdominal wall block to see if it provides better pain relief after minimally invasive left-sided colon surgery. It may help patients experience less pain and use fewer pain medications.
Belo Horizonte, Minas GeraisAges 18–80 - NCT07380789Recruiting
Managing acute chest pain after battle injuries
This study is testing better ways to manage severe chest pain after combat injuries in Ukraine. If you have chest pain from battle and are 18 or older, it may help find a treatment that works for you.
RivneAges 18–60 - NCT07388745Recruiting
Comparing two pain blocks for heart bypass surgery
This study compares two different nerve-block injections (one near the spine, one under the shoulder blade) to see which provides better pain relief after heart bypass surgery. If you are scheduled for a planned bypass and are in reasonably good health, you might be able to join.
KütahyaAges 45–85
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.