Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT07378215RecruitingPhase 4
Steroids for better recovery after hip replacement
This study tests whether a single dose of steroids (dexamethasone) given during hip replacement surgery can improve your recovery and quality of life. It may help reduce pain and swelling after the procedure.
Genk, LimburgAges 60 years+ - NCT07373275Enrolling by invitation
Lifestyle Medicine for Teen Migraine
This study tests whether a lifestyle medicine program (like healthy habits and stress management) can help reduce migraine headaches in teenagers. It's for teens who get frequent migraines and are patients at certain MaineHealth clinics.
Scarborough, MaineAges 14–18 - NCT07373210Recruiting
Placebo pills for hip surgery pain in teens and young adults
This study tests whether taking placebo pills (pills with no active drug) can help manage pain after a specific hip surgery, called Bernese Periacetabular Osteotomy (PAO), in people with a hip condition called developmental dysplasia. The goal is to see if using placebos can reduce the need for pain medications and help with recovery.
San Francisco, CaliforniaAges 13–40 - NCT07378059Recruiting
Loxoprofen patch for shingles pain
This trial tests if a loxoprofen skin patch (a non-steroidal anti-inflammatory drug) can safely relieve moderate to severe pain from shingles. It may be an option for people who have had shingles rash for less than 90 days.
BeijingAges 18 years+ - NCT07377370Recruiting
Pain after gum graft surgery study
This study looks at factors that affect pain after a gum graft procedure. If you need gum surgery to cover exposed tooth roots or add gum tissue, you may be able to join.
Barcelona, Sant Cugat Del VallesAges 18 years+ - NCT07371442Enrolling by invitation
Audio distraction and acupoint stimulation for kids during tooth extraction
This study tests two non-drug methods to help children feel less pain and worry during a tooth extraction: an audio-video distraction (like a movie or music) and a special pressure point (acupoint) stimulation on the hand. It aims to see which approach works best for kids ages 5 to 8 who need a baby tooth removed.
Al MansurahAges 5–8 - NCT07376915Recruiting
Mental imagery for ankle weakness: A pilot study
This study tests a new way of using mental imagery and gentle movements to help people with long-term ankle weakness. It may improve ankle stability without the need for surgery.
IstanbulAges 18–40 - NCT07374952RecruitingPhase 4
Finding the smallest effective dose for a clavicle nerve block
This study tests how much numbing medicine is needed to block nerves below the collarbone during shoulder surgery. It aims to find the smallest effective dose to reduce side effects.
Montreal, QuebecAges 18–70 - NCT07378735Recruiting
Back to Life: early rehab after spinal fusion surgery
This trial tests an early rehabilitation program for people having lumbar spinal fusion surgery to see if it helps them get back to daily life faster. It may be a good option if you live in Copenhagen or Frederiksberg and have had low back pain for more than three months.
Glostrup MunicipalityAges 18 years+ - NCT07377721RecruitingPhase 1
Study of HRS-2129 for diabetic nerve pain
This trial tests a new medicine called HRS-2129 for people with long-term nerve pain caused by diabetes. It aims to see if the drug can safely reduce pain.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06841601Recruiting
Shaking or cold for less pain during dental shots
This trial tests whether a vibrating tool or a cold pack can help reduce pain when children get a numbing shot at the dentist. If your child needs a simple filling and is generally healthy, this study might help make their experience more comfortable.
AlexandriaAges 5–9 - NCT06414356RecruitingPhase 4
Ketamine for nerve pain and PTSD in military personnel
This study tests whether ketamine infusions can help with ongoing nerve pain and PTSD symptoms. It's for active-duty service members, veterans, and retirees who have had moderate nerve pain for at least 3 months.
San Antonio, TexasAges 18–70 - NCT06158529Recruiting
High-frequency spinal cord stimulation for diabetic nerve pain
This trial tests if a special type of spinal cord stimulation (high-frequency SCS) can better relieve painful nerve damage caused by diabetes. If you have long-term burning, stabbing, or electric-shock-like pain in both legs, this treatment may help reduce that pain.
BeijingAges 18–80 - NCT07367126Recruiting
Nerve pain in knee osteoarthritis: Pain and function study
This study looks at nerve-related pain in people with knee osteoarthritis and how it affects their pain level and daily function. It may help understand if nerve pain is a key factor in your knee OA symptoms.
IstanbulAges 40–70 - NCT07363681Recruiting
Comparing Two Anesthesia Methods for Urological Surgery
This study compares two types of anesthesia during urological surgery: inhaled gases versus a medicine called dexmedetomidine. The goal is to see which one helps you recover more smoothly in the recovery room.
Istanbul, IstanbulAges 39–99 - NCT07370428Recruiting
Numbing injection for pain relief after lower back surgery
This study tests whether an ultrasound-guided numbing injection near the hip area can provide better pain relief after lower back surgery. If you qualify, you may receive this injection to help control pain after your operation.
BursaAges 18–65 - NCT07368920Recruiting
TENS for low back pain in adults
This study tests if a non-invasive device called TENS (which uses gentle electrical pulses) can help relieve low back pain that comes from muscle knots or tight bands. The device is applied to the skin over the painful area.
Xi'an, ShaanxiAges 18–65 - NCT07365566Recruiting
Pain and sleep behavior disorder study
This study looks at pain in people with a sleep condition called idiopathic REM sleep behavior disorder (iRBD), where people act out their dreams. It also includes a group of people with narcolepsy who have similar sleep issues. The goal is to understand how pain relates to these conditions.
ToulouseAges 18 years+ - NCT07366684Recruiting
Heart attack study for adults 75 and older
This study looks at how frailty and other health factors affect recovery in people 75 and older who have had a heart attack or unstable chest pain. It may help doctors better understand who is at higher risk and how to improve care for older adults.
NišAges 75 years+ - NCT07369440Recruiting
Power training for fall risk in older adults
This study tests whether a community-based power training program can help reduce fall risk in older adults. It compares results for people who have fallen in the past year and those who haven't.
Maia, Porto DistrictAges 65 years+ - NCT07370389Recruiting
Testing a new pain drug for shingles pain
This trial tests a new pain medication called tulodesvenlafaxine for people with shingles-related pain. It may help if you have moderate to severe pain that started within the last 90 days.
BeijingAges 18 years+ - NCT07367568Recruiting
Nerve block comparison for mastectomy pain relief
This trial compares two types of nerve blocks to help manage pain during and after modified radical mastectomy. You may qualify if you are a woman between 18 and 65, have a healthy weight, and are scheduled for this surgery.
CairoAges 18–65 - NCT07366138Recruiting
Nerve blocks for pain after sleeve gastrectomy surgery
This trial compares two ultrasound-guided nerve blocks to manage pain after laparoscopic sleeve gastrectomy. If you are having this weight-loss surgery, these blocks might help reduce your need for pain medicine and improve your recovery.
Banhā, BenhaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.