Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07244029Recruiting
Herbal extract for pain and swelling after wisdom tooth surgery
This trial tests if an herbal extract called Reparil (aescin) can reduce pain, swelling, and stiffness after impacted wisdom tooth removal. It compares Reparil to a standard pain reliever (ibuprofen) to see which works better for recovery.
Muscat, Al KhoudAges 18–40 - NCT07248540Recruiting
IV magnesium for severe period pain
This trial tests whether an IV magnesium injection can quickly reduce severe period pain. If you have very painful periods without other underlying conditions, this study may help find better relief options.
Gaziosmanpaşa, Outside of the USAges 18–35 - NCT06904703Recruiting
Nerve blocks for older adults having hip replacement surgery
This trial tests two types of nerve blocks to see which one works better for pain control in older adults undergoing total hip replacement. A nerve block is a shot of anesthetic near a nerve to numb a specific area, and the goal is to help you feel less pain after surgery.
TantaAges 75 years+ - NCT05723081Recruiting
Study of stress, coping, and pain risk in Native Americans
This study looks at how stress and coping (“resilience”) may affect risk for pain. It may help researchers understand why some people develop ongoing, bothersome pain and how stress might play a role.
Tulsa, OklahomaAges 18 years+ - NCT07241559Recruiting
Low back pain treatment study: injection and mobilization
This study tests two treatments for chronic low back pain: a special injection of dextrose (a sugar solution) guided by ultrasound, and a technique to mobilize the fascia (connective tissue) in the lower back. It aims to see if these help people who haven't found relief from standard treatments.
Ankara, AltındağAges 18–65 - NCT07242170Recruiting
Comparing nerve blocks for pain after knee replacement surgery
This trial tests if adding extra nerve blocks (sciatic, BiFeS, or IPACK) to the usual adductor canal block can reduce pain after total knee replacement. The goal is to find a better way to manage pain and improve recovery.
Erzincan, MerkezAges 18–75 - NCT07247552Recruiting
Personalized rTMS for chronic pain
This study tests if personalized repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help reduce chronic pain. It aims to find out if targeting specific brain areas based on your pain patterns works better than standard treatment.
GistrupAges 18–80 - NCT07240883Recruiting
Endometriosis research study using a mobile app
This study is for people with endometriosis who want to help researchers learn more about the condition. You will use a smartphone app or website to share information, which could help improve future care.
EdinburghAges 16 years+ - NCT07243327Recruiting
Shockwave therapy vs standard rehab for hip pain
This trial compares two treatments—shockwave therapy and conventional physical therapy—for long-lasting pain on the outside of the hip, often called trochanteric pain syndrome. It aims to find which option works better for people whose hip pain has persisted for months.
IstanbulAges 18–65 - NCT07242872Enrolling by invitation
Screen addiction and pain after nose surgery
This trial looks at whether screen addiction affects pain levels after rhinoplasty (nose job). It will help doctors understand if screen habits influence recovery.
Tokat Province, Tokat ProvinceAges 18–45 - NCT07247929Recruiting
Pain and swelling after third molar surgery
This trial compares two surgical methods for removing partially impacted wisdom teeth to see which causes less pain and swelling afterwards.
Islamabad, IslamabadAges 18–45 - NCT07245303Recruiting
How Light Affects Pain in Chronic Pain
This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT07240961Recruiting
Nerve block for pain after hip replacement
This study tests whether a nerve block injection in the back (called an erector spinae plane block) can provide better pain relief after a first-time hip replacement. It may help reduce the need for strong painkillers.
ManoubaAges 18–85 - NCT07243587Recruiting
Study of endometriosis affecting the bowel
This study observes women with deep endometriosis that affects the colon or rectum to better understand the condition and improve treatment. Your participation will help researchers learn more about this type of endometriosis.
BordeauxAges 18 years+ - NCT07248631Recruiting
Exercises and mindful walking for diabetic nerve pain
This study tests whether combining foot and ankle exercises with mindful walking can reduce pain and improve mobility in people with diabetic nerve damage in their feet.
Multan, Punjab ProvinceAges 3.3 years–6.3 years - NCT07248514Recruiting
Pilates for kids with backpack-related back pain
This study tests if Pilates exercises can help children aged 12-16 who have back pain and poor posture from carrying heavy backpacks.
Lahore, Punjab ProvinceAges 12–16 - NCT04898491Recruiting
Pain behavior scale study for adults who cannot speak
This study checks whether a “pain behavior” checklist works well and gives consistent results in adults who can’t communicate verbally and who have an artificial airway. It may help clinicians better recognize pain in people who cannot tell them directly.
Madrid, MadridAges 18 years+ - NCT07248475Recruiting
Battle rope training for elbow pain and stiffness after injury
This study tests whether battle rope exercises can help children ages 8–15 with elbow stiffness and pain after an injury. It aims to improve movement and reduce discomfort.
Lahore, Punjab ProvinceAges 8–15 - NCT07245121Recruiting
Sugar water injections for chronic knee arthritis pain
This trial tests whether injecting a sugar-water solution around the nerves of the knee can reduce chronic pain from osteoarthritis. It is for people with long-term knee pain, stiffness, and cracking who have not had recent knee treatments or surgery.
Athens, AtticaAges 38 years+ - NCT07241949Recruiting
Nerve block for gallbladder surgery pain relief
This study tests a nerve block called the external oblique intercostal block to reduce pain after laparoscopic gallbladder removal. If you are having this surgery, the block may help you need less pain medication and feel more comfortable after the procedure.
AdanaAges 18–65 - NCT07244861Enrolling by invitation
TENS for neck muscle stiffness and pain
This study tests whether a gentle electrical stimulation device (TENS) applied to the neck can reduce muscle stiffness and pain in people with ongoing neck pain. If you have had neck pain for at least 6 weeks and are willing to avoid certain medications the day before, you may be able to join.
ErzurumAges 18–50 - NCT07241728Recruiting
Bruxism and electrical current for jaw pain relief
This study tests whether a type of mild electrical current (called diadinamic current) can help relieve jaw pain caused by bruxism (teeth grinding or clenching). It is for adults who have not tried other treatments for this pain.
MalatyaAges 18 years+ - NCT07247669Recruiting
AI phone triage for emergencies
This study tests if artificial intelligence can help identify time-sensitive emergencies like stroke, heart attack, or trouble breathing from recorded phone calls. The goal is to make emergency response faster and more accurate.
Málaga, MálagaAges Any age - NCT07247825Recruiting
Needle treatment for shoulder tendon pain: single vs multi-filament
This study tests two types of a needle-based treatment (percutaneous electrolysis) for shoulder tendon pain. It aims to see if a single-filament or multi-filament approach works better for people with chronic supraspinatus tendon issues.
SalamancaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.