Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT05851976RecruitingPhase 4
Duloxetine for short-term non-radiating low back pain
This trial tests duloxetine (a medicine used for certain pain conditions and mood) for easing low back pain that started recently and doesn’t shoot down your leg. It may help reduce pain and improve daily function after an ER visit, but you must meet several safety and medication-use criteria.
The Bronx, New YorkAges 18–64 - NCT05857696Recruiting
Spinal Stimulation to Improve Walking in Chronic Back and Leg Pain
This pilot study tests whether a special spinal cord stimulator—a small device that sends gentle electrical signals to your spinal cord—can help you walk better if you have ongoing nerve pain in your lower back and leg after spine surgery. The goal is to reduce pain and improve your ability to move around.
NiceAges 18–70 - NCT05858996RecruitingPhase 2
Testing a pain care guideline for older adults with dementia
This trial tests a clinical guideline to improve how pain is identified and managed. It may help if you or your loved one has dementia and ongoing pain, with a focus on better pain care in nursing homes.
Baltimore, MarylandAges 60 years+ - NCT05862792Recruiting
Liposomal bupivacaine during robotic throat surgery
This study gives a pain-relief medicine (bupivacaine in a slow-release form) during transoral robotic throat surgery. It aims to see if it improves comfort and pain control around the time of surgery.
Danville, PennsylvaniaAges 18 years+ - NCT05863312Recruiting
Study of outcomes after retinal detachment repair
This study looks at how well surgery works for people with a specific type of detached retina (rhegmatogenous retinal detachment). It may help improve how doctors choose and manage treatment, based on what outcomes happen after repair.
Québec, QuebecAges 18 years+ - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100 - NCT05865470RecruitingPhase 1
How age affects smoked and oral THC effects
This early-stage study compares how people in different age groups respond to THC taken by smoking versus by mouth. It aims to understand age-related differences in effects and safety, which could help guide safer use in the future.
Los Angeles, CaliforniaAges 18–65 - NCT05865600Recruiting
PET/CT guided planning for treatment in chronic coronary disease
This trial uses a heart scan (PET/CT) to better estimate blood flow in people with long-term coronary artery disease. It aims to help doctors choose the best treatment strategy and decide who may need more invasive testing or procedures.
Herning, Central JutlandAges 18 years+ - NCT05867186Recruiting
Get fit during childhood cancer treatment and aftercare
This trial tests a “fit to fight” program to help children and teens stay active during and after cancer treatment. It aims to support physical and possibly emotional well-being while treatment is happening, based on whether your care team thinks it’s safe and helpful for you.
Mainz, Rhineland-PalatinateAges 3–21 - NCT05868330RecruitingPhase 4
Compare two nerve-block methods for shoulder replacement
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
Iowa City, IowaAges 18–90 - NCT05873894Recruiting
Testing pain changes during brain surgery under anesthesia
This trial studies how pain levels change during planned brain surgery while you are fully asleep, using special brain-monitoring recordings. The goal is to better understand acute pain signals during general anesthesia, which may help anesthesiologists manage pain more effectively.
ValenciaAges 18 years+ - NCT05877157Recruiting
Study how pain and opioids change after surgery
This study follows adults in the hospital after surgery to understand how pain and opioid (strong pain medicine) use affect them. Your answers on questionnaires help researchers see what happens after different types of anesthesia.
Zagreb, Vinogradska 29Ages 18 years+ - NCT05878665Recruiting
Low-dose contrast dye for CT scans in suspected appendicitis
This trial tests whether using a smaller amount of contrast dye in a CT scan still gives doctors enough information to diagnose suspected appendicitis. It’s aimed at emergency department patients who are already scheduled for an abdomen and pelvis CT with dye.
SeoulAges 19–44 - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT05885061Recruiting
Spinal cord stimulation study for adults with chronic pain
This study looks at how spinal cord stimulation affects chronic pain in adults who already have the device implanted. It may help researchers understand who benefits most and how stable pain and treatments need to be to measure results.
AarhusAges 18–99 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT05894772Recruiting
Virtual portal program for youth waiting for chronic pain care
This study tests a virtual “stepped care” portal (a website/app) to help young people manage chronic pain while they’re waiting to start specialized care. It aims to see whether the portal improves support and outcomes during the wait time.
Halifax, Nova ScotiaAges 12–18 - NCT05895383RecruitingPhase 4
Nitrous oxide breathing during vasectomy: a feasibility study
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
Boston, MassachusettsAges 21–85 - NCT05896826Recruiting
Magnetocardiography to better spot heart attack patients
This study tests whether magnetocardiography—a scan that measures heart signals using magnets—can more accurately identify myocardial infarction (heart attack). It may help doctors detect heart attacks faster and more accurately using safer, non-invasive testing.
Jinan, ShandongAges 18–79 - NCT05897632Recruiting
Rapid chest-pain evaluation for moderate-risk adults
This trial tests a faster “ambulatory rapid evaluation” approach for adults who come in with chest pain that could be heart-related, but is not clearly an emergency. It may help doctors quickly sort who is safe to send home and who needs urgent heart testing, using specific ECG and blood test results.
Detroit, MichiganAges 21 years+ - NCT05898035Recruiting
Testing symptoms after root-end dental surgery
This study looks at what symptoms you feel after endodontic microsurgery (a type of root-end tooth procedure). It will help doctors understand what to expect after surgery in properly selected patients.
IrbidAges 18–65 - NCT05903027Recruiting
Testing gepant migraine treatment for better side effects
This trial studies how well a “gepant” medicine works for different types of migraine and how tolerable it is. It may help if you have frequent migraines and you can keep a headache diary as the study asks.
FlorenceAges 18 years+ - NCT05905419Recruiting
Brain scan study of opioid effects in women with pain
This study uses brain imaging (MRI) to understand how opioid medications may affect the brain in women. People with chronic pain who take opioids (or do not) and healthy women without chronic pain may be invited to participate.
Durham, North CarolinaAges 18 years+ - NCT05906134RecruitingPhase 1/Phase 2
Pain control plan after minimally invasive esophagus surgery
This trial tests a pain-control method (using an epidural/nerve pain-block through the back, called neuraxial anesthesia) for people having minimally invasive esophagus removal surgery. It may help reduce pain after surgery and improve comfort during recovery.
Seattle, WashingtonAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.