Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT05218785Recruiting
Botulinum toxin for calf tightness and long-term heel pain
This trial tests whether injections of botulinum toxin A can loosen a tight calf muscle and improve long-lasting plantar fasciitis (heel/foot pain). It’s for people whose symptoms have lasted at least a year and who haven’t improved enough with physical therapy.
Oslo, OsloAges 18–75 - NCT06679205Recruiting
Multidisciplinary care for long-term low back pain
This study tests a team-based, non-drug treatment program for long-term low back pain. It combines physical therapy, education, and support to help reduce pain and improve daily function.
Barcelona, BarcelonaAges 18 years+ - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT07256626Enrolling by invitation
Soundwave Wellness Study for Back Pain
This trial tests a soundwave-based wellness program for back pain. It's a simple study that asks you to follow instructions, so if you're interested in trying a non-invasive approach, this could be a good fit.
New York, New YorkAges Any age - NCT07258290Recruiting
Freesolve Magnesium Scaffold for Heart Artery Blockages
This trial tests a new dissolvable magnesium scaffold to treat blockages in heart arteries. It is designed for people with stable heart pain or certain recent heart attacks, and it aims to open blocked arteries and then slowly dissolve over time.
Washington D.C., District of ColumbiaAges 18–80 - NCT07250828Enrolling by invitation
BurstDR spinal cord stimulation for painful diabetic neuropathy
This trial tests a type of spinal cord stimulation called BurstDR to see if it can reduce pain from diabetic nerve damage. It may help people with diabetes who have ongoing leg pain that hasn't gotten better with standard pain medications.
Grand Island, NebraskaAges 19 years+ - NCT07257770Recruiting
Gel for breast pain after surgery
This trial tests a soothing gel you apply to your breast to see if it relieves pain after surgery. It might help if you still feel discomfort around your surgical wound.
RomaAges 18–70 - NCT06731335RecruitingPhase 2
Psilocybin for chronic nerve pain that hasn't improved with other treatments
This study tests whether psilocybin (a compound found in certain mushrooms) can help reduce chronic nerve pain that has not responded well to standard medications. You will receive study treatment plus psychotherapy to see if it improves your pain.
Toronto, OntarioAges 18–65 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT07251387Recruiting
How muscles work together during pain and when expecting pain
This study looks at how your muscles coordinate when you're in pain or just expecting it. Healthy volunteers will be asked to walk or run while researchers measure muscle activity and test a cream's effect.
SherbrookeAges 18–35 - NCT07253025Recruiting
Comparing Two Root Canal Fillings for Pain Relief
This study compares two types of root canal filling materials—a resin-based sealer and a bioceramic sealer—to see which one causes less pain after the procedure. If you have a tooth with a painful, infected nerve (irreversible pulpitis), this trial may help determine which filler offers better comfort.
Peshawar, Khyber Pakhtoon Khawa(KPK)aAges 17–70 - NCT07253012Recruiting
AI pain relief assistant for surgery patients
This trial tests a computer system that helps manage pain during surgery. It may be an option if you are having a planned surgery lasting between 2 and 4 hours.
SantiagoAges Any age - NCT07258537Enrolling by invitation
Comparing two hand therapies for sacroiliac joint pain
This study compares two types of hands-on therapy (a gentle side-lying adjustment vs. a lower back roll) to see which works better for long-lasting low back pain caused by the sacroiliac joint. If you have ongoing pain and are open to physical treatments, this trial may help find the best approach.
Gujrat, Punjab ProvinceAges Any age - NCT07257744Recruiting
Pain management after open heart surgery: comparing three methods
This trial compares three ways to manage pain after open heart surgery to see which best prevents long-term chronic pain. It may help you decide with your doctor which pain control option is right for you.
Trabzon, TrabzonAges 18–85 - NCT07250399Recruiting
Pain after root canal treatment with different tools
This trial compares two different ways of cleaning a tooth's root canal to see which causes less pain during and after treatment. It is for people with severe tooth pain in an upper premolar.
CairoAges 20–50 - NCT07250568Recruiting
Office exercise program for low back pain in workers
This study tests if a special office exercise program can help people with low back pain feel better, reduce stress, and improve their quality of life. It includes exercises and posture advice for people who work at computers.
Depok, West JavaAges 18–58 - NCT07259291Recruiting
Comparing two remifentanil dosing methods during anesthesia
This trial compares two ways of giving the pain medicine remifentanil during anesthesia. It looks at how well the computer models predict the right dose for each patient.
TrevisoAges 18–80 - NCT07255248RecruitingPhase 4
Knee fat pad pain study for young female athletes
This study tests a treatment for knee fat pad pain in teenage girls who play organized sports. It aims to see if a specific injection helps after physical therapy hasn't worked.
Norwood, MassachusettsAges 12–18 - NCT07254169Enrolling by invitation
Herbal medicine for post-accident fatigue
This trial tests if a special herbal medicine treatment can help people who still feel very tired after a traffic accident. It aims to see if the treatment is safe and effective for reducing fatigue.
Seoul, Gangnam-GuAges 40–69 - NCT07256145Recruiting
Ultrasound-guided nerve block for post-shingles pain
This study compares a new ultrasound-guided nerve block (erector spinae plane block) with standard care to help manage stubborn nerve pain after shingles. It might be an option if usual medications havent helped your pain.
Alexandria, AleexandriaAges 20–70 - NCT07251959Enrolling by invitation
Exercise vs. exercise plus manual therapy for chronic back pain
This study tests whether a workplace exercise program, with or without hands-on manual therapy, can help reduce chronic spinal pain in desk workers. It is designed for UCAM University staff who have had persistent back pain for at least 3 months.
Murcia, MurciaAges 18 years+ - NCT07250984Enrolling by invitation
Treating stubborn facial pain
This trial tests a treatment for unusual facial pain that doesn't get better with standard care. It may help if you have facial pain and no psychiatric condition.
LjubljanaAges 18–75 - NCT06153589Recruiting
Music therapy for leg ulcer pain relief
This trial tests whether listening to music during wound cleaning can reduce pain for people with leg ulcers caused by vein or artery problems. It aims to make the procedure more comfortable.
Fort-de-FranceAges 18 years+ - NCT05507853Recruiting
Study of body pain sensitivity during pregnancy
This study looks at “central sensitization,” which means the nervous system may become more sensitive to pain, in pregnant people. It aims to understand pain changes during pregnancy and how different factors may affect them.
GothenburgAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.