Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06538233RecruitingPhase 2
Pain after buffered vs. non-buffered numbing medicine
This trial compares two versions of a numbing medicine (articaine) to see which causes less pain during dental work on upper front teeth.
Cleveland, OhioAges 18–60 - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06541184Recruiting
Ziconotide via spine pump for chronic non-cancer pain
This study looks at a medicine called ziconotide, given through a pump in your spine (intrathecal delivery) to treat chronic pain that is not from cancer. It aims to learn how safe and effective this treatment is in real-world patients.
AubagneAges 18 years+ - NCT06542666Recruiting
Cognitive functional therapy for chronic shoulder pain
This trial tests a new approach called cognitive functional therapy for people with long-term shoulder pain. It combines mental strategies with gentle movements to help you manage pain and improve function.
João Pessoa, ParaíbaAges 18–60 - NCT06543316Recruiting
Treating gastric bypass ulcers with low-thermal argon plasma
This study tests a new way to treat painful sores (marginal ulcers) that can happen after gastric bypass surgery. Doctors use a special tool (argon plasma) during an endoscopy to help the sores heal faster, and you will get standard ulcer medicine too.
Boston, MassachusettsAges 18 years+ - NCT06544291RecruitingPhase 2
THC and CBD for pain and opioid use disorder
This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.
New Haven, ConnecticutAges 18–65 - NCT06544525Recruiting
Pain test to predict physical therapy results for back pain
This trial tests whether a simple pain test can predict how much you will improve with physical therapy for chronic low back pain. It looks at how your body naturally handles pain, which may help tailor your treatment.
Fort Sam Houston, TexasAges 18–64 - NCT06545448Recruiting
Study of planned angioplasty in stable heart disease
This study looks at whether planned angioplasties (a procedure to open blocked heart arteries) are done appropriately for people with long-term stable heart disease. It aims to help doctors make better decisions for patients like you.
São Paulo, São PauloAges 18 years+ - NCT06548646Recruiting
Nerve blocks for pain relief after mastectomy
This study compares two types of nerve blocks (thoracic interfascial plane block vs. erector spinae plane block) to see which provides better pain relief after a mastectomy. It may help you have less pain and need fewer painkillers after surgery.
Cairo, AbbasiyaAges 21 years+ - NCT06549660Recruiting
Light therapy for chronic low back pain relief
This study tests if a special light treatment (photobiomodulation) can temporarily ease chronic low back pain that comes and goes. It's for people who have had this pain for at least 3 months and speak Portuguese.
São PauloAges 18–65 - NCT06549985Recruiting
Group care for endometriosis pain
This trial tests a weekly group program combining education, movement, and support to help manage chronic pelvic pain caused by endometriosis. It aims to improve quality of life without surgery.
St Louis, MissouriAges 18–48 - NCT06550869Recruiting
A new nerve block for less pain after kidney surgery
This trial tests a specific nerve block (anterior quadratus lumborum block) given during laparoscopic kidney surgery to see if it reduces pain and speeds recovery. It may help patients who need a nephrectomy (kidney removal) or partial nephrectomy.
Hangzhou, ZhejiangAges 18–80 - NCT06552936Recruiting
Laser therapy for faster healing after tooth extraction
This study tests whether using a special laser after a lower-jaw tooth extraction can help the socket heal faster and grow new bone. It may benefit people who plan to get a dental implant later.
Lahore, Punjab ProvinceAges 21 years+ - NCT06554106Recruiting
Electrical stimulation for fibromyalgia pain
This trial tests whether a gentle electrical stimulation therapy can reduce pain and improve daily life in people with fibromyalgia. It aims to offer a drug-free option to manage symptoms.
ElâzığAges 18–65 - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06556121Recruiting
Numbing shot for gender-affirming surgery pain
This trial tests a numbing shot given during penile inversion vaginoplasty to see if it reduces pain after surgery. It might help people manage pain with less need for strong painkillers.
Toronto, OntarioAges 18–70 - NCT06556758Recruiting
Stripping massage for rhomboid trigger points in women
This study tests whether a specific massage technique (stripping massage) can relieve upper back pain caused by trigger points in the rhomboid muscles. It focuses on women aged 18 to 40 who have not had neck or shoulder surgery.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT06557993Recruiting
Nerve block injection for myofascial pain syndrome
This study tests a type of nerve block injection (called serratus posterior superior intercostal plane block) guided by ultrasound to see if it helps relieve pain from myofascial pain syndrome. It may be a treatment option for people with MPS who haven't had recent procedures.
IstanbulAges 18–65 - NCT06559215RecruitingPhase 2
Pain management with Exparel after knee surgery in teens
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Frisco, TexasAges 13–21 - NCT06559852Recruiting
Yoga for endometriosis pain relief study
This study tests whether a 12-week yoga program can reduce pain in women with endometriosis. It requires that your diagnosis was confirmed by surgery and that you’re not already doing yoga.
Hershey, PennsylvaniaAges 18–45 - NCT06559735Recruiting
Brain oxygen measurement in chronic pain with spinal cord stimulation
This trial tests a new device to measure oxygen levels in the brain of people with chronic pain who are receiving spinal cord stimulation. It aims to see if brain oxygen changes can help manage pain better.
Walnut Creek, CaliforniaAges 18 years+ - NCT06561815Recruiting
Body composition test in heart attack patients
This trial looks at how a simple, painless test called bioelectrical impedance analysis can measure your body's water, fat, and muscle. It may help doctors understand how these factors affect recovery from a heart attack or unstable angina.
Buenos Aires, Buenos AiresAges 18 years+ - NCT06564064Recruiting
Abdominal Binders After Cesarean Delivery
This trial tests whether wearing an abdominal binder after a C-section helps you feel better and recover faster. It's for women who have had a previous C-section and are having another one.
SohagAges Any age
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.