Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06566144Recruiting
Adding osteopathy to standard care for chronic low back pain
This study tests whether adding osteopathy (a type of hands-on therapy) to standard care helps people with long-term low back pain feel better and move more easily. It is for adults with chronic, nonspecific back pain that has lasted at least 6 weeks.
São PauloAges 18–70 - NCT06567093Recruiting
Massage for pain during heel blood draw in newborns
This study tests whether a gentle leg and heel massage can help reduce pain in newborns during a standard heel blood test. It's for healthy babies born at full term (38–41 weeks) who are less than a month old.
Bartın, ProvinceAges 1 day–4 weeks - NCT06568406Recruiting
Early physiotherapy after episiotomy for better recovery
This study tests whether starting physiotherapy early after a childbirth-related cut (episiotomy) can help with pain, pelvic floor function, sexual health, and overall quality of life.
BrnoAges 18–40 - NCT06568770RecruitingPhase 2/Phase 3
Comparing two nerve blocks for femur fracture surgery pain
This trial tests if one type of nerve block (PENG block) works better than another (S-FICB) for controlling pain during and after femur fracture surgery. Both blocks are guided by ultrasound to help with your recovery.
Sahiwal, Punjab ProvinceAges 20–70 - NCT06569953RecruitingPhase 4
Numbing Medicine for Pain After Lung Surgery
This study tests whether a long-lasting numbing medicine (liposomal bupivacaine) injected near the spine can better control pain after lung surgery. It compares this to a standard numbing medicine, and aims to help patients recover with less pain after surgery.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06570577Recruiting
Nerve block for pain after cervical spine surgery
This trial tests whether a nerve block can reduce the need for opioid pain medication after back-of-neck spine surgery. It may help patients have better pain control with fewer side effects.
Stony Brook, New YorkAges 18–75 - NCT06572241Recruiting
Spinal morphine for better labor pain relief
This study tests whether adding a small dose of morphine into the spinal fluid improves pain relief from an epidural during labor. If you are having your first baby and want pain relief, you may be able to take part.
Toronto, OntarioAges 18–50 - NCT06573996Recruiting
Testing a mouth TENS device for braces pain
This trial tests if a small device placed inside the mouth can ease pain from braces. You'll receive either real or fake treatment with the TENS device to see if it helps with soreness after adjustments.
San Francisco, CaliforniaAges 12 years+ - NCT06574009RecruitingPhase 4
Better options for chronic cancer pain in veterans
This study tests if switching from long-term opioid painkillers to buprenorphine (a different type of pain medication) can provide better pain relief for veterans who have had cancer but are currently cancer-free. It aims to find a safer and more effective way to manage chronic pain.
Indianapolis, IndianaAges 18–99 - NCT06574165Recruiting
Pain, mood, and brain inflammation in veterans with fibromyalgia
This study looks at how brain inflammation and mood relate to pain in veterans with fibromyalgia. It may help find new ways to treat pain by understanding these connections.
Birmingham, AlabamaAges 19–85 - NCT06576830RecruitingPhase 4
Pain relief study for kids having tonsil surgery
This study tests different ways to manage pain after tonsillectomy in children. The goal is to find better pain relief options.
Durham, North CarolinaAges 3–17 - NCT06577233RecruitingPhase 4
Nerve block before robotic endometriosis surgery
This trial tests if a nerve block (injecting numbing medicine) before robotic surgery for endometriosis can help control pain after the procedure. It's for women aged 18-65 who are already planning this surgery.
Houston, TexasAges 18–65 - NCT06580327Recruiting
Epidural Drip vs. Intermittent Doses for Women in Labor
This study compares two ways of giving epidural pain medicine during labor—continuous drip versus intermittent doses. It is for women who have given birth before and are in early labor with a single, head-down baby.
NazarethAges Any age - NCT06580990Recruiting
Neck exercises for whiplash recovery
This study tests whether specific neck exercises can help people with whiplash-related neck pain. If you've had a recent whiplash injury and have moderate pain, this program may improve your recovery.
Concepción, BiobioAges 18–65 - NCT06582810Recruiting
Lidocaine for headaches after brain bleed
This study tests whether a lidocaine infusion (given through an IV) can safely reduce severe headaches after a subarachnoid hemorrhage (a type of brain bleed). You may qualify if you had a spontaneous bleed and can communicate your pain level.
Wichita, KansasAges 18 years+ - NCT06583122Recruiting
Nerve block study for occipital pain or migraine
This trial tests if using ultrasound-guided heat (radiofrequency ablation) on the occipital nerve can reduce headache pain. It is for people with occipital neuralgia or migraine pain at the back of the head who haven't had enough relief from oral medications.
Kansas City, KansasAges 18–80 - NCT06584721Recruiting
Foot exercises and taping for low back pain with flat feet
This study tests whether simple foot exercises combined with special tape on the foot can reduce low back pain in people whose feet roll inward too much (a condition called hyper-pronation). It may help if you have had back pain for months and also have flat feet.
Wāh, Punjab ProvinceAges 25–45 - NCT06585033Recruiting
Spinal cord stimulation for pain after back surgery
This trial tests how much of the pain relief from spinal cord stimulation is due to the placebo effect. It is for people with ongoing leg pain after back surgery who have already tried other treatments without success.
ArnhemAges 18–70 - NCT06584799RecruitingPhase 3
Medication for pelvic vein disorder symptoms
This trial tests a venoactive drug (a medication that improves vein tone and blood flow) to see if it relieves symptoms like pelvic pain, pain during sex, and discomfort in the lower belly caused by pelvic varicose veins (enlarged veins). It may help people who have these symptoms confirmed by ultrasound.
MoskvaAges 18–45 - NCT06586840Recruiting
Adding an extra nerve block to knee replacement
This trial tests if adding a special nerve block behind the knee (IPACK) to a standard thigh block helps control pain better after total knee replacement. It may lead to less pain and faster recovery.
AydinAges 18–85 - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT06587607Recruiting
VR mindfulness training for veterans with spinal cord injury
This study tests whether mindfulness training with virtual reality can help veterans with spinal cord injury manage chronic pain. It is done from home using a VR headset and group video calls.
Houston, TexasAges 18 years+ - NCT06587724Recruiting
Testing a questionnaire for myositis
This study is testing a new questionnaire called the BETY-BQ to see if it is a good tool for measuring how well people with myositis are doing—things like symptoms and function. The goal is to make it easier for doctors to track your progress over time.
Ankara, AltındağAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.