Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07558278RecruitingPhase 4
LINQ procedure vs standard care for sacroiliac joint pain
This study compares a new procedure called LINQ—which stabilizes the sacroiliac joint (the joint where your spine connects to your pelvis)—against standard pain management for chronic sacroiliac joint pain. The trial tests whether this procedure reduces pain and disability better than medications and physical therapy alone.
Shenandoah, TexasAges 21 years+ - NCT07551323Recruiting
Myofascial Release vs. Pilates for Chronic Low Back Pain
This study compares two hands-on treatment approaches—myofascial release (deep tissue massage) and Pilates exercises—to see which works better for chronic low back pain that isn't caused by nerve damage. If you have persistent lower-back pain, this trial might help you find relief through one of these therapies.
Istanbul, IstanbulAges 18–45 - NCT07040605Recruiting
Neck exercises for chronic pain
This study tests a special set of exercises for your neck muscles to help with chronic neck pain. It focuses on strengthening deep muscles and improving how your body senses neck movement.
Cairo, Giza GovernorateAges 20–40 - NCT05575323Recruiting
Same-day radiation and stabilization for spine metastases
This trial tests whether giving focused radiation (SBRT) on the same day as spine surgery to stabilize the spine helps control symptoms from spinal metastases. It may help reduce pain and improve stability, especially when tumors threaten or affect the spine’s strength.
UtrechtAges 18 years+ - NCT07552298Recruiting
Dextrose Injection for Long-Term Tailbone Pain
This study tests whether injecting dextrose (a sugar solution) into the tailbone area can relieve chronic tailbone pain that hasn't improved with standard treatments like physical therapy or medications. If it works, it could offer patients a minimally invasive option to reduce pain and improve daily function.
IstanbulAges 18–65 - NCT07150637Enrolling by invitation
Predicting muscle weakness in children on a breathing machine
This study aims to predict muscle weakness that can happen to children on breathing machines in the ICU. It could help doctors start treatments earlier to prevent this weakness.
Shanghai, Shanghai MunicipalityAges 1 month–18 years - NCT07043127Recruiting
Strength training after hip replacement with blood flow restriction
This trial tests a new kind of physical therapy after hip replacement. It combines strength exercises with a special technique called blood flow restriction to see if it helps you recover muscle strength faster.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06491030RecruitingPhase 4
Brace use after spinal fusion for adults with spine curves
This trial tests whether wearing a back brace after surgery helps prevent problems at the top of a spinal fusion. It is for adults aged 30-75 having their first spine fusion from near the middle of the back down to the tailbone or pelvis.
Carmel, IndianaAges 30–75 - NCT05708430RecruitingPhase 2
Test stem-cell mixture injection for painful thumb arthritis
This Phase 2 study tests how safe an injection made from your own body fat cells (stroma vascular fraction) is in people with painful arthritis at the base of the thumb. It also looks at whether pain and hand function improve after the injection.
AmiensAges 18 years+ - NCT07147491RecruitingPhase 4
Study of a powered exercise device after hip surgery
This study tests a powered exercise device to help people walk better after hip surgery. It's for adults who are medically stable and can sit and stand with support.
Yongin-si, Gyeonggi-do, South KoreaAges 19 years+ - NCT06267248Enrolling by invitation
3D scanning to guide spine surgery
This trial tests a 3D scanner that maps your spine during surgery to help the surgeon work more accurately. It is for people already planning spine surgery where the back bones are exposed.
Boston, MassachusettsAges 18–80 - NCT06193057Recruiting
Custom vs standard total ankle replacement trial
This study compares a custom-made artificial ankle joint to a standard one for people with arthritis in one ankle. If you are a candidate for a first-time ankle replacement, this trial could help find out which type of implant works best.
Bologna, BOAges 40–75 - NCT05710627Recruiting
Testing TENEX for hip pain from greater trochanteric pain syndrome
This trial studies whether TENEX (a minimally invasive procedure) can reduce hip pain caused by greater trochanteric pain syndrome (GTPS). It is for people who have tried non-surgical treatments for at least 6 months without enough relief, and who have confirmed GTPS on imaging (MRI or CT).
The Bronx, New YorkAges 30–90 - NCT07553611Recruiting
Regional anesthesia and shoulder surgery recovery outcomes
This study compares different numbing techniques used during shoulder arthroscopy (a minimally invasive shoulder surgery) to see which one helps patients recover better, use less pain medication, and experience fewer complications like temporary paralysis of the breathing muscle under the rib cage.
Antalya, MuratpaşaAges 18–65 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT07715201Recruiting
Amino acid drink for strength and recovery in active men
This study tests whether a special amino acid supplement helps trained men get stronger, perform better, and recover faster from workouts. You'll take the supplement daily and follow a 10-week supervised training program.
Toronto, OntarioAges 18–45 - NCT07060781Recruiting
Managing fluid buildup after lower back surgery
This trial tests ways to prevent or reduce seroma (fluid buildup) after elective lower back decompression surgery. It aims to improve recovery and comfort for patients.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT06337123Recruiting
Testing a new knee replacement implant for total knee replacement
This study tests a specific knee replacement implant (the Physica TT Tibial Plate) in people needing a total knee replacement. The goal is to see how well it works and how safe it is.
Forte dei Marmi, LuccaAges 18 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT06527287Recruiting
Ankle training for stability in active adults
This trial tests a new ankle training program for people with chronic ankle instability who are physically active. It aims to improve ankle function and reduce the risk of future injuries.
Lexington, KentuckyAges 18–44 - NCT07493239Recruiting
Testing a supplement for knee pain and mobility
This trial studies whether a dietary supplement called MyCondro™ can improve joint health and movement in people with knee osteoarthritis. You will take the supplement for up to 16 weeks and track your symptoms using a smartphone app.
Los Angeles, CaliforniaAges 45 years+ - NCT07307495Recruiting
Pain relief after back surgery and its effect on recovery
This study tests a new painkiller, oliceridine fumarate, given through a pump after lumbar spine surgery. The goal is to see if it helps the bowels and stomach recover faster compared to standard pain relief.
Xi'an, ShaanxiAges 18–75 - NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT07542470Enrolling by invitationPhase 4
Cold and compression therapy after spinal surgery
This study compares a new cold and compression device (NICE1) to standard care after spinal surgery to see if it reduces pain and swelling. If you're having spine surgery, this trial tests whether keeping the area cold and compressed helps you recover better.
Sarasota, FloridaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.