Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07131787Recruiting
Blood flow restriction training after Achilles tendon repair
This study tests whether adding blood flow restriction training to standard rehab helps your Achilles tendon and calf muscle heal better after surgery. You would do exercises with a special cuff that gently limits blood flow to your leg.
Ghent, East-FlandersAges 18 years+ - NCT06349629Recruiting
Testing a new dissolving metal implant for joint fractures
This trial tests a new 3D-printed metal implant made of a special magnesium alloy that dissolves over time. It is designed to help mend broken bones near joints, such as wrist, shoulder, or knee fractures, where there is a missing piece of bone.
Beijing, HaidianAges 18–80 - NCT06065449RecruitingPhase 3
Comparing two radiation therapies for painful bone metastases
This trial compares two types of radiation therapy to relieve pain from cancer that has spread to the bones. It aims to see whether a more targeted, high-dose approach (SBRT) works better than standard palliative radiation.
Houston, TexasAges 18 years+ - NCT07128862Recruiting
Strength training with or without blood flow restriction in athletes
This trial compares heavy weightlifting with and without blood flow restriction (using special bands) to see which works better for building strength in active athletes. If you are a sprinter or football player, you may be able to join.
Lahore, Punjab ProvinceAges 18–35 - NCT05927701Recruiting
Long-term outcomes in adolescent scoliosis patients
This study asks people with adolescent idiopathic scoliosis about how they feel today and how they use healthcare services. It compares people who had surgery versus those who were treated without surgery, but only includes those with long follow-up since their teen years.
BrugesAges 18 years+ - NCT07662668Recruiting
NSAID effect on periostin in back pain patients
This trial tests how a common anti-inflammatory drug (NSAID) affects a protein called periostin, which may be linked to spine problems. It could help people with herniated discs or spinal stenosis.
DaeguAges 20–80 - NCT05664815RecruitingPhase 2
Amniotic membrane treatment for advanced jaw bone loss
This Phase 2 trial studies whether a human amniotic membrane dressing can help heal stage II maxillomandibular osteonecrosis of the jaw (MRONJ). It focuses on people who developed MRONJ after certain cancer-related bone treatments and who may need surgery and antibiotics.
BesançonAges 18 years+ - NCT07600632Recruiting
Hip Replacement Surgery Outcomes Using Short Stem
This study reviews results from hip replacement surgery using a special short implant inserted through a small front-of-hip incision. Researchers want to understand how well this approach works and how long the implant lasts.
BolognaAges 18 years+ - NCT07542808RecruitingPhase 2/Phase 3
Stem cell treatment vs. hyaluronic acid for knee arthritis
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Abu DhabiAges 18 years+ - NCT05653687Recruiting
Hip replacement surgery: X-ray guidance versus usual hand placement
This trial compares two ways of guiding hip replacement surgery during the operation. It may help improve how accurately the surgeon places the hip components and how well patients do afterward.
Lugano, Canton TicinoAges 18–90 - NCT06711575Recruiting
Personalized antibiotics for spinal infections
This trial is studying how to personalize the dose of anti-infection drugs for people with spinal infections. The goal is to find the best treatment for each patient to improve outcomes and reduce side effects.
JinanAges Any age - NCT06363942Recruiting
Video exercise program for fall prevention in frail older adults
This trial tests a personalized video-based exercise program to help older adults who are frail or pre-frail prevent falls. It may be a good fit if you are relatively healthy aside from frailty concerns.
Montreal, QuebecAges 70 years+ - NCT06711744Recruiting
Comparing dental implants after tooth extraction
This study compares different types of dental implants placed right after a tooth is removed. It may help people with a failing tooth who have healthy gums and surrounding teeth.
Rome, RMAges 18–99 - NCT05361941Recruiting
Antibiotic graft to help bone regrow in infected knee surgery areas
This trial tests an antibiotic “graft” placed into or near infected bone cavities around a knee replacement (TKA) to help new bone grow. You may be considered if you have an infected knee implant area and can safely take part in follow-up visits and treatment.
Los Angeles, CaliforniaAges 22 years+ - NCT07597538Recruiting
How Hip Replacement Changes Knee Position and Function
This study examines whether getting a hip replacement changes how your knee aligns and functions. Researchers will compare knee imaging before and after your surgery to understand this connection.
Asyut, Asyut GovernorateAges Any age - NCT05898243Recruiting
Study of injuries after shoulder dislocation in adults over 40
This study follows people over age 40 who have their first traumatic “front” shoulder dislocation to learn what injuries happen and how they can be identified. It may help doctors better understand what to check for after this kind of injury.
Sabadell, BarcelonaAges 40 years+ - NCT07113405Recruiting
Tea extract and knee strength after downhill jogging
This study tests whether taking a tea extract can help your knee muscles recover faster after a downhill jog. It compares the tea to a placebo to see if it reduces muscle soreness or weakness.
Fribourg, Canton of FribourgAges 18–40 - NCT07068880Recruiting
New flexor tendon repair technique study for adults
This study tests a new device for fixing certain torn tendons in the hand and arm. It may help if you have an injury in specific areas (zones 2-5) and fit size requirements.
Orlando, FloridaAges 22–88 - NCT07159919Recruiting
Insect vs animal protein for building muscle
This trial compares protein from insects to protein from animals to see which helps build muscle better. If you are a regular weightlifter and open to taking a protein supplement daily for 12 weeks, this study may help you understand more about your muscle health.
Guildford, SurreyAges 18 years+ - NCT06723730Recruiting
Mobilization and core strength for rotator cuff pain
This trial tests if adding a specific type of shoulder movement therapy and upper body core exercises can reduce pain and improve function in people with rotator cuff-related shoulder pain. It may help you if you have had shoulder pain for more than 6 weeks and it started after an injury.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT06677359Recruiting
Creatine and exercise for older adults
This study tests whether a creatine supplement, taken with or without a gentle exercise program, can help older adults stay stronger and more independent. It's designed for people aged 75 and older who can still walk.
Pamplona, NavarreAges 75 years+ - NCT06724679Recruiting
Virtual reality for chronic back pain treatment
This trial tests if using a virtual reality (VR) headset can help people with long-term lower back pain during a spine rehabilitation program. It will see if VR is a practical and helpful addition to the program.
AngersAges 18–65 - NCT07559890Recruiting
Nerve ablation for low back pain with Modic changes
This study tests a procedure that uses heat to stop a nerve in the lower back from sending pain signals. It may help people with long-term central low back pain who have not gotten better with other treatments and have Modic changes on MRI.
PragueAges 18 years+ - NCT07484698Recruiting
Myofascial release with FIFA 11+ for hamstring health
This study tests whether adding a gentle muscle release technique to a proven warm-up program (FIFA 11+) can improve hamstring flexibility and lower your risk of injury. It's for male football players who can commit to a 6-week program.
Chakdara, KPKAges 16–30
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.