Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,420 recruiting studies in this area right now.
By phase
- Not applicable9,752
- Phase 2783
- Phase 1576
- Phase 3536
- Phase 4343
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke844
- Parkinson Disease426
- Alzheimer Disease342
- Multiple Sclerosis341
- Dementia227
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Insomnia155
- Spinal Cord Injuries153
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment130
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California679
- Massachusetts300
- New York292
- Florida275
- Texas266
- Maryland246
- Arizona213
- Alabama210
- Illinois187
- Pennsylvania178
Recruiting studies12,418 total
- NCT07568067Recruiting
Accelerated Brain Stimulation for Parkinson's Disease
This trial tests a new type of brain stimulation (called temporal interference stimulation) targeted at specific brain regions to help improve Parkinson's disease symptoms. Researchers will use MRI imaging and behavioral assessments to see if this approach can reduce movement problems and improve quality of life.
Guangzhou, GuangdongAges Up to 85 years - NCT06096675Recruiting
Physical activity study for cardiac amyloidosis patients
This study tests whether a 12-week supervised exercise program is safe and helpful for people with cardiac amyloidosis and heart failure. It aims to see if regular exercise can improve how you feel and function.
Charlotte, North CarolinaAges 18 years+ - NCT07715006Recruiting
Spinal nerve stimulation for children with cerebral palsy
This study adds a mild electrical stimulation to the spinal nerves during a planned SDR surgery for children with cerebral palsy, to see if it helps improve movement more than the surgery alone.
Pittsburgh, PennsylvaniaAges 3–14 - NCT07282847RecruitingPhase 1/Phase 2
Gene therapy for adults with Pompe disease
This study tests a one-time gene therapy (AB-1009) for adults with late-onset Pompe disease. It aims to see if the treatment is safe and improves muscle and breathing function.
Phoenix, ArizonaAges 18–65 - NCT07715136RecruitingPhase 1
BCMA-CD19 CAR-T for Refractory Inflammatory Myopathy
This trial tests a new type of cell therapy (BCMA-CD19 cCAR-T) for people with inflammatory myopathy that hasn't improved with standard treatments. The goal is to see if this treatment can help control the disease.
Chengdu, SichuanAges 18–60 - NCT07715656Recruiting
Middle-meningeal-artery embolization for chronic subdural hematoma
This trial studies a procedure called middle-meningeal-artery embolization, which blocks the blood supply to a chronic subdural hematoma (a slow-growing blood collection around the brain). It compares outcomes in people with one-sided versus both-sided bleeds, and aims to see if this less invasive treatment can help reduce the need for surgery or improve recovery.
Burlington, MassachusettsAges 18 years+ - NCT07712913RecruitingPhase 3
Pregabalin for nerve pain from diabetes or shingles
This trial tests an extended-release version of pregabalin (a pain medication) for people with long-term nerve pain caused by diabetes or shingles. It aims to see if this once-daily pill can reduce pain with fewer side effects.
Salvador, Estado de BahiaAges 18–75 - NCT06814496RecruitingPhase 1/Phase 2
Radiation and immunotherapy combo for DLL3-positive cancers
This trial combines radiation with an immunotherapy drug called tarlatamab to treat cancers that make a protein called DLL3. The goal is to see if this combination works better than either treatment alone for people with certain types of lung cancer and other tumors that have not responded to prior therapy.
Tucson, ArizonaAges 18–99 - NCT07713537Recruiting
Stroke risk score for AF patients on blood thinners
This study is testing a new scoring system to predict stroke risk in people with atrial fibrillation who are taking DOAC blood thinners. The goal is to help doctors personalize treatment and prevent blood clots.
Barcelona, BarcelonaAges Any age - NCT06322602Recruiting
Brain tumor biopsy with Ommaya reservoir for fluid collection
This study places a small reservoir under your scalp during a brain tumor biopsy to collect fluid samples over time. It may help doctors learn more about your tumor and how it responds to treatment.
Rochester, MinnesotaAges 18 years+ - NCT07714694Recruiting
Testing a new intermittent catheter for men
This study asks men who use a specific type of catheter (hydrophilic, size 14 French, 40 cm long) at least three times a day to try a new catheter and share their experience through online questionnaires. The goal is to see how well the new catheter works for daily use.
Libertyville, IllinoisAges 22 years+ - NCT05278208RecruitingPhase 1/Phase 2
Lutathera for high-grade brain tumors that returned or got worse
This trial tests if Lutathera, a radioactive drug that targets certain tumors, can help children and young adults with high-grade brain tumors or meningiomas that have come back or are growing. It aims to see if the treatment is safe and works.
Aurora, ColoradoAges 4–39 - NCT04714892Recruiting
Taste and smell differences in obesity
This study looks at how taste and smell may differ in people with obesity compared to healthy-weight individuals. It aims to understand why some people perceive flavors differently, which could help develop better treatments for weight management.
Bethesda, MarylandAges 18–65 - NCT07629687Recruiting
Ear Nerve Stimulation for Balance After Stroke
This trial tests a non-invasive device that stimulates a nerve in your ear to help improve balance and body control after stroke. It may help you regain stability and reduce symptoms like muscle tightness.
Islamabad, Punjab ProvinceAges 18–70 - NCT07610369RecruitingPhase 2
Psilocybin therapy for depression in Parkinson's disease
This study tests whether psilocybin (a psychedelic compound) combined with therapy can reduce depression in people with Parkinson's disease. If you have moderate-to-severe depression and Parkinson's, this trial may offer a new treatment option.
New Haven, ConnecticutAges 40–80 - NCT07629791Recruiting
Augmented reality and brain stimulation for balance problems
This study tests whether combining augmented reality (a computer-based visual experience) with a non-invasive brain stimulation technique called tDCS can help improve balance and walking in people with balance impairment. You would receive therapy sessions using both technologies together.
Rawalpindi, Punjab ProvinceAges 18–90 - NCT07713706Enrolling by invitation
Brain activity study for speech production
This study looks at how the brain stops speech, using electrical recordings taken during your already-planned epilepsy monitoring. It may help understand speech control.
Pittsburgh, PennsylvaniaAges 8–26 - NCT07629856Recruiting
Dual-Task Training to Improve Balance After Stroke
This study tests whether doing balance exercises while performing mental tasks together can help stroke survivors improve their stability and walking ability. Many stroke patients struggle with balance, and this training aims to help them regain confidence and reduce fall risk.
Chak One Hundred Fifty-seven, Punjab ProvinceAges 40–75 - NCT06136728RecruitingPhase 3
Dalfampridine and physical therapy for walking problems in MS
This trial tests whether adding dalfampridine to physical therapy helps people with multiple sclerosis walk better. You must not already be taking dalfampridine or getting physical therapy to join.
Boston, MassachusettsAges 25–75 - NCT06143514Recruiting
Study of BRIUMVI in breast milk
This study looks at how much BRIUMVI (ublituximab) gets into breast milk. It helps understand if the drug is safe for breastfed babies whose mothers are already taking it for relapsing multiple sclerosis.
San Francisco, CaliforniaAges 18 years+ - NCT07405762Recruiting
Stroke recovery after blood clot removal: brain blood flow study
This trial looks at how blood flow and brain activity change in the first days after a stroke caused by a large blockage in the front part of the brain. It tests if certain patterns can help predict recovery after a procedure to remove the clot.
Xi'an, Shan'xiAges 18–85 - NCT00869817Recruiting
Study for adults at risk of inherited Alzheimer’s
This study follows people who are at risk for a specific inherited form of Alzheimer’s disease (because a parent has it). It helps researchers learn how the disease starts and changes over time, especially in people who still feel cognitively normal.
Jacksonville, FloridaAges 18 years+ - NCT04437498Recruiting
Vagus nerve stimulation for veterans with mild brain injury and PTSD
This study looks at whether stimulating the vagus nerve can improve symptoms in veterans who have mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). If you qualify, you may be offered a device-based treatment and monitored for safety and symptom changes.
Decatur, GeorgiaAges 18–55 - NCT07088991Recruiting
Study of adults with NF1 and plexiform neurofibromas in Russia
This study is collecting information about adults in Russia with Neurofibromatosis type 1 who have symptomatic plexiform neurofibromas and have not yet been treated with a MEK inhibitor. It aims to better understand the condition and its treatment in real-world settings.
ArkhangelskAges Any age
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,420 recruiting neurology studies from the U.S. registry right now, out of 19,378 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.