Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2781
- Phase 1578
- Phase 3536
- Phase 4343
- Phase 1/Phase 2306
- Phase 2/Phase 3123
Top conditions
- Stroke841
- Parkinson Disease429
- Multiple Sclerosis345
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries154
- Insomnia152
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke137
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida273
- Texas268
- Maryland246
- Arizona214
- Alabama210
- Illinois189
- Pennsylvania175
Recruiting studies12,405 total
- NCT07781579Recruiting
MRI study to predict bleeding risk in moyamoya disease
This study uses advanced MRI scans to better predict the risk of bleeding in people with moyamoya disease, a rare condition where brain arteries narrow. It aims to improve prevention of bleeding strokes.
Beijing, Beijing MunicipalityAges Any age - NCT06555419RecruitingPhase 1
Nusinersen dosing study via flexible spinal catheter
This trial investigates how the drug nusinersen (Spinraza) enters the body when given through a small, flexible tube placed in the lower back (ThecaFlex DRx system). It aims to learn how the drug is processed in adults and children with spinal muscular atrophy, which could help make dosing more convenient.
Orange, CaliforniaAges 3 years+ - NCT06697808Recruiting
Ultrasound for detecting brain issues in children
This study tests whether a portable ultrasound can safely spot brain problems in children who already need a CT scan or MRI. The goal is to see if ultrasound could be a faster, easier alternative for finding issues in the emergency room or intensive care unit.
Charlotte, North CarolinaAges Up to 18 years - NCT00001465Recruiting
Study of lymphangioleiomyomatosis (LAM) disease process
This study looks at the natural history and disease process of lymphangioleiomyomatosis (LAM), a rare lung disease that mostly affects women. It may help understand how LAM progresses and how it affects daily life, and may include exercise testing and other evaluations.
Bethesda, MarylandAges 16–100 - NCT06509789Recruiting
Brain stimulation intensity for arm recovery after stroke
This trial tests whether a specific type of brain stimulation, called theta burst stimulation, can help improve arm movement in people who have had a stroke. It looks at how different intensities of the stimulation affect recovery.
Hong Kong, Hong KongAges 18–80 - NCT07783074Recruiting
Fatigue study using digital outcomes in multiple sclerosis and long COVID
This study is investigating fatigue using digital outcomes in people with multiple sclerosis, long COVID, and healthy volunteers. Participants must own a smartphone, be fluent in German or English, and be willing to provide informed consent. Exclusion criteria include having taken certain medications recently, being pregnant or lactating, or having additional health conditions that could affect fatigue or the autonomic nervous system.
Basel, BaselAges 18–65 - NCT05434637Recruiting
Somatosensory tinnitus treatment study
This study tests a physical therapy approach for people whose tinnitus (ringing in the ears) can be changed by moving their head, neck, or jaw. It aims to see if this treatment can reduce the bothersome nature of the sound.
Portland, OregonAges 18 years+ - NCT05096481RecruitingPhase 2
Vaccine for brain tumors in children and young adults
This trial tests a vaccine that may help the immune system fight brain tumors (medulloblastoma, high-grade glioma, and DIPG). It is for patients who have already had standard treatment and whose tumors are still present or have returned.
Aurora, ColoradoAges 3–39 - NCT07431749Recruiting
Brain stimulation to measure and improve arm recovery after stroke
This study uses a brain stimulation technique called transcranial magnetic stimulation (TMS) to measure and possibly change the communication between the two sides of the brain in people who have had a stroke. The goal is to understand how this brain imbalance affects arm and hand recovery, and whether TMS can help improve function.
Hong KongAges 18–80 - NCT06974461Recruiting
Blood flow restriction training for stroke-related muscle loss
This study tests whether a special type of strength training (using bands to partially block blood flow) can improve muscle strength and physical function in people who have had a stroke and have muscle loss. It is designed to help improve daily activities and overall mobility.
Hung Hom, KowloonAges 50 years+ - NCT05213572Recruiting
Deep health check study for adults with sickle cell disease
This study looks at how major organs like the brain, kidneys, heart, and liver are affected in adults with sickle cell disease, whether they've had a bone marrow transplant or gene therapy, or are continuing regular treatment. You'll get detailed tests that can help doctors understand the disease better, which may lead to improved care.
Bethesda, MarylandAges 18–100 - NCT07781566Recruiting
Speech therapy intensity for cleft palate speech errors in children
This study looks at how well two different intensities of speech therapy work for children with a cleft palate who have speech sound errors. It aims to find the best way to help your child speak more clearly.
Ghent, East-FlandersAges 4 years+ - NCT07589595RecruitingPhase 2
Donanemab for Early Cognitive Decline with Lewy Bodies
This study tests donanemab, an investigational drug designed to target amyloid proteins in the brain that may contribute to cognitive decline in people with early dementia with Lewy bodies. The trial aims to see if this treatment can slow cognitive decline and help preserve thinking and memory.
Chandler, ArizonaAges 55–85 - NCT06506877Enrolling by invitation
A tool to screen for cognitive risk in primary care
This study is testing a new tool to help primary care providers spot early signs of thinking or memory problems in older adults. If you are a provider who sees patients aged 60 and up and can prescribe medicine, you may be able to join.
Cleveland, OhioAges Any age - NCT07587242RecruitingPhase 3
Testing a New Therapy for DMD with Exon 44 Mutations
This study tests whether a new medicine called AOC 1044 (delpacibart zotadirsen) can help boys with Duchenne muscular dystrophy (DMD) who have a specific genetic mutation. The medicine works by helping the body skip a damaged part of the gene to make a functional protein.
LeuvenAges 7–16 - NCT06994728Recruiting
How DBS affects vision and freezing of gait in Parkinson's
This trial looks at how deep brain stimulation (DBS) affects the way you see and move, and how that relates to freezing of gait (when your feet suddenly feel stuck). If you have Parkinson's disease, already have a DBS device, and experience freezing, this study may help researchers understand your symptoms better.
Charleston, South CarolinaAges 18 years+ - NCT05253131RecruitingPhase 2
Selumetinib plus durvalumab for advanced sarcoma
This Phase 2 study tests whether selumetinib and durvalumab can slow or shrink certain advanced sarcomas. It’s for adults with disease that has come back, progressed, or can’t be safely removed with surgery.
Birmingham, AlabamaAges 18–99 - NCT07002034RecruitingPhase 2
RE104 for adjustment disorder related to cancer or other serious illnesses
This trial is testing a new medication (RE104) for people who have adjustment disorder with depressed mood or anxiety because of a serious medical condition like cancer, ALS, MS, Parkinson's, or lung fibrosis. It's a study to see if the drug is safe and reduces symptoms.
Birmingham, AlabamaAges 18–80 - NCT07137832RecruitingPhase 3
Testing clot-busting drug during stroke treatment for medium vessel blockages
This trial tests whether giving a clot-dissolving medication directly into the brain's blood vessels during a standard procedure (mechanical thrombectomy) can improve outcomes for people with a stroke caused by a blockage in a medium-sized artery. It may be an option for patients who arrive at the hospital within 24 hours of symptom onset and have enough salvageable brain tissue.
Guangzhou, GuangdongAges 18 years+ - NCT05156398RecruitingPhase 3
Rimegepant to prevent migraine attacks in children
This trial studies whether rimegepant can reduce how often migraine attacks happen in children and teens. It also looks at safety and how well the treatment fits day-to-day life and school activities.
Fort Smith, ArkansasAges 6–17 - NCT07571538Recruiting
VisionApp Ghosting Study for People with Mild Nearsightedness
This research study tests an app designed to understand how people with mild nearsightedness experience visual ghosting (blurred or doubled images). Your participation could help improve vision correction technology.
Bloomington, IndianaAges 8 years+ - NCT07430917RecruitingPhase 2
Testing J147 for recent stroke from blocked artery
This trial tests a new drug, J147, for people who recently had a stroke caused by a blocked artery and have already had a procedure to reopen that artery. It aims to see if the drug can improve recovery.
Long Beach, CaliforniaAges 18–90 - NCT07231380Recruiting
Comparing two ways to remove clots in stroke
This study tests two methods of removing a large blood clot from a brain artery during stroke. The goal is to see which method helps restore blood flow faster and more safely.
Nashville, TennesseeAges 18 years+ - NCT06502171RecruitingPhase 1
Cabozantinib and selumetinib for plexiform neurofibromas
This trial tests a combination of two targeted drugs (cabozantinib and selumetinib) for people with NF1 who have plexiform neurofibromas that are growing or causing significant problems. The goal is to see if this combination can shrink or slow the growth of these tumors.
Birmingham, AlabamaAges 16 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,231 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.