Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05237505RecruitingPhase 2
Sleep apnea plus COPD study to check heart and breathing effects
This Phase 2 study looks at the cardiovascular (heart/blood vessel) effects of having both sleep apnea and COPD. It may help doctors better understand who is at risk and how to manage these breathing problems together.
La Jolla, CaliforniaAges 40–79 - NCT05237817Recruiting
Links stroke history to accidental adrenal gland findings
This study looks at whether certain accidental adrenal gland growths found on scans are linked to having had a stroke. It may help doctors understand stroke risk factors and how adrenal findings should be interpreted.
BeijingAges 18–100 - NCT05238272Recruiting
tRNS device to improve mirror therapy after stroke
This trial tests a brain-stimulation device (tRNS) paired with precision mirror therapy to improve arm movement after a stroke. It may help people with moderate to mild arm weakness regain more control, but you must meet several safety and health criteria.
TaoyuanAges 35–85 - NCT05240014Recruiting
Powered leg braces to help people move more easily
This study tests modular powered leg braces (orthoses) to improve voluntary movement and walking ability in adult participants. It may help you learn whether the braces are safe and useful for your kind of mobility and daily movement.
Ann Arbor, MichiganAges 18–85 - NCT05239858Recruiting
International registry for people with Wilson’s disease
This trial is a patient registry that collects health information from people with Wilson’s disease, including those without symptoms yet and those taking any type of treatment. It helps researchers understand the disease and how it progresses, which can support future studies and care improvements.
LeuvenAges 12 years+ - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05242393Recruiting
How daily body rhythms relate to recovery after stroke
This observational study looks at how your body’s daily rhythms may affect brain recovery after an ischemic stroke. It may help researchers understand what timing-related factors influence “neuroplasticity,” meaning the brain’s ability to adjust and heal.
Saint PetersburgAges 18–80 - NCT05242419Recruiting
Huperzine A to reduce confusion after non-heart surgery
This trial studies whether a medicine called huperzine A can reduce “postoperative delirium,” which is sudden confusion after surgery, in older adults. It focuses on people having non-heart surgery under general anesthesia for at least two hours.
Wenzhou, ZhejiangAges 75 years+ - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT05245500RecruitingPhase 1
Study drug for solid tumors with MTAP gene deletion
This Phase 1 trial studies MRTX1719, a new medicine, in solid tumors that have a missing MTAP gene (MTAP deletion). It aims to find the safest dose and check how the drug affects the tumor.
Phoenix, ArizonaAges 18 years+ - NCT05247125RecruitingPhase 4
Testing light or melatonin to help brain recovery after stroke
This study looks at whether changing your sleep timing using light therapy or melatonin can improve “brain rewiring” after an ischemic stroke. It mainly focuses on people who arrive very soon after stroke symptoms and who also meet specific safety and sleep/medication requirements.
Saint PetersburgAges 18–80 - NCT05250180Recruiting
Animal-assisted therapy for kids after brain injury
This study looks at whether guided time with therapy animals helps children recover after an acquired brain injury, and what factors affect whether it works. Families may be asked to allow animal sessions and track responses over time.
Cincinnati, OhioAges 4–24 - NCT05250375Recruiting
Study of mitochondrial muscle diseases over time
This natural history study follows children and adults with suspected or confirmed mitochondrial myopathy to better understand symptoms and how the condition changes. It may also include healthy participants to compare test results and improve future treatments.
Philadelphia, PennsylvaniaAges birth–100 years - NCT05250349Recruiting
Ultrasound brain blood flow and thinking in stable heart failure
This trial studies whether a noninvasive ultrasound test of blood flow in the brain, along with memory and thinking questionnaires, can help explain thinking changes in people with stable heart failure. It may help researchers better understand why some people develop cognitive (thinking) difficulties as heart failure progresses.
Krakow, MPAges 18 years+ - NCT05251415Recruiting
Study of rare autoimmune diseases with blood and medical samples
This trial collects clinical and lab information (like blood and medical history) from people with rare autoimmune diseases, especially when symptoms are unusual. It aims to better understand what causes these illnesses and how newer treatments may help.
ToulouseAges 6–99 - NCT05253560Recruiting
Study prodromal Parkinson signs in GBA1 mutation carriers
This study looks at early (before full disease) Parkinson-like symptoms in people who carry a specific genetic change called GBA1. It may help researchers understand who could develop Parkinson’s and how early signs can be tracked.
Jerusalem, Please Select...Ages 40–75 - NCT05254197Recruiting
Brain tumor monitoring study with follow-up brain scans
This study follows people with lower-grade (WHO grade 2 or less) brain tumors using repeat MRI scans over time. It helps doctors understand how these tumors change and which patients may safely delay treatment at first.
SeoulAges 18 years+ - NCT05254730Recruiting
Testing brain-recording sensors to map the seizure source
This study looks at using special tiny filaments during brain monitoring to better identify where seizures start. It’s meant for people with hard-to-control (refractory) epilepsy who are already being considered for a specific brain-monitoring procedure.
Montreal, QuebecAges Any age - NCT05257967Recruiting
Testing spinal fluid in EGFR-mutant lung cancer with brain covering spread
This trial looks at spinal fluid (also called CSF) in adults with EGFR-mutant lung cancer that has spread to the lining around the brain/spinal cord. The goal is to better understand the disease and what the spinal fluid tests may show to guide care.
Vancouver, British ColumbiaAges 18 years+ - NCT05259605Recruiting
Study uses brain tumor tissue and scans to track treatment outcomes
This is an observational study that collects and compares information from patients with primary brain tumors and their treatment results. It uses stored tumor tissue and brain scans to better understand outcomes using updated tumor classification methods.
InnsbruckAges 18 years+ - NCT05260125RecruitingPhase 4
Ultrasound-guided shoulder nerve block for stroke pain
This trial compares two ways to deliver a shoulder nerve block to relieve long-lasting shoulder pain after stroke: one guided by ultrasound and one without. It may help if your stroke-related shoulder pain has lasted at least a few months and you may benefit from a targeted pain-relief injection.
BoluAges 25–75 - NCT05260307Recruiting
Improving hearing of multiple voices and speech understanding
This study tests ways to improve how people perceive space in sound and understand speech when many voices are talking at once. It may help adults with normal hearing or hearing loss better follow conversations in noisy, “overlapping voices” situations.
Boston, MassachusettsAges 18–80 - NCT05260177Recruiting
40 Hz light therapy for mild to moderate Alzheimer’s
This study tests whether a non-invasive 40 Hz light therapy system can help people with early Alzheimer’s. You’ll likely use the device at home and wear a small activity monitor, while doing memory and thinking tests.
RoskildeAges 40 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.