Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05908214Recruiting
Electrical stimulation for leg stiffness and overactive nerves
This study tests a treatment using high-frequency electrical stimulation to reduce overactive nerve signals that can cause stiff legs, poor ankle control, cramps, or restless legs. It may help improve movement and comfort during walking or at night, depending on the condition.
LausanneAges 18 years+ - NCT05908279Recruiting
Walking and gait study in people with Parkinson’s disease
This trial studies walking patterns and how walking is controlled in people with Parkinson’s disease. It may help researchers understand movement control and improve future therapies by comparing walking ability and patterns.
Louvain-la-NeuveAges 18–99 - NCT05908266Recruiting
Training control for reaching in Parkinson disease
This study tests a way to help people control reaching movements during a task. You may be able to join if you can understand the instructions and successfully perform the reaching task during the experiment.
Louvain-la-NeuveAges 18–99 - NCT05908591Recruiting
Pregnancy sleep study on breathing, blood vessel function, and safety
This study looks at how sleep and breathing changes during pregnancy may affect blood vessel function and pregnancy safety. You may be asked about your sleep and possibly have health checks during the middle of pregnancy.
Edmonton, AlbertaAges 18 years+ - NCT05908760Recruiting
Breathing carbon dioxide may help low blood pressure symptoms
This proof-of-concept pilot study tests whether a controlled breathing test that re-breathes carbon dioxide can improve symptoms or body responses in people with neurogenic orthostatic hypotension (a drop in blood pressure when standing). It may help researchers understand how the nervous system involved in blood pressure control works.
Calgary, AlbertaAges 18–100 - NCT05908812Recruiting
Testing how blood sugar control links to a hormone in type 2 diabetes
This study looks at whether better blood sugar control changes levels of a hormone called irisin in people with type 2 diabetes and obesity, including those with or without age-related muscle loss (sarcopenia). Your results may help researchers understand the body’s response to diabetes and could guide future treatment ideas.
BariAges 60 years+ - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT05909839Recruiting
7-Tesla brain MRI network study for deep brain stimulation tremor
This study looks at detailed brain imaging using a very strong MRI (7-Tesla) to understand brain network changes after deep brain stimulation for essential tremor. It may help improve how DBS works and how tremor can be better treated in the future.
Amsterdam, North HollandAges 18 years+ - NCT05910944Recruiting
Study of early iNPH signs using brain scans
This European study looks at people with early (prodromal) signs of idiopathic normal pressure hydrocephalus (iNPH), a condition that can affect walking and thinking. It uses brain imaging and brief walking/cognitive checks to see who has this early pattern and may benefit from further evaluation.
KuopioAges Any age - NCT05911932Recruiting
Genetic testing in people with memory or nerve diseases
This study looks at genetic (inherited) information using a blood sample from people who come to a memory/cognitive clinic, including some with related family history. Results may help researchers understand who is at risk and how these conditions develop.
London, OntarioAges 18 years+ - NCT05911646Recruiting
Tool to help decisions for mild sleep apnea in kids
This trial looks at OSA-18, a questionnaire that may help families and clinicians make better decisions about treatment for a child’s mild sleep apnea. It specifically focuses on children with enlarged tonsils and mild sleep study results.
Hartford, ConnecticutAges 3–12 - NCT05913167Recruiting
Back and belly nerve blocks during laparoscopic kidney removal
This trial compares two different pain-control techniques (blocks near the back or near the abdominal muscles) during laparoscopic kidney removal surgery. It may help find which method works better for comfort and recovery after surgery.
KocaeliAges 18–65 - NCT05913531Recruiting
Use of past delirium data from adult patients
This trial looks back at information already collected from past patients, focusing on delirium (confusion that can happen during serious illness or after anesthesia). It doesn’t test a new treatment—its goal is to learn patterns from existing records to improve future care.
BerlinAges 18–100 - NCT05915000Recruiting
CSF protein tests to predict shunt response in hydrocephalus
This study looks at fluid-based “CSF” protein markers to predict how well a brain shunt works in adults with chronic hydrocephalus (fluid buildup). If you qualify, your CSF sample may help doctors better estimate your likely response to treatment.
Valencia, ValenciaAges 18 years+ - NCT05914038Recruiting
Personalized brain stimulation to improve arm recovery after stroke
This trial studies whether personalized rTMS (a noninvasive brain stimulation) can help improve arm and hand strength after a recent stroke. It may help people who still have weaker upper-limb movement within the first few months after stroke.
Taipei County, TaipeiAges 20 years+ - NCT05914649Recruiting
Testing long COVID and POTS brain fog symptoms
This study tests how different long-COVID and POTS-related symptoms—especially “brain fog”—show up and improve. It may help researchers better measure symptoms so future treatments can be targeted more effectively.
Calgary, AlbertaAges 18–60 - NCT05915377Recruiting
Screening for hospital confusion in older adults
This trial is testing practical ways to recognize delirium, a sudden type of hospital confusion, in older patients. It may help your care team spot confusion earlier and respond sooner.
Boston, MassachusettsAges 70 years+ - NCT05917119Recruiting
Bright light therapy for obstructive sleep apnea symptoms
This study tests whether a “bright light” treatment can reduce daytime sleepiness in people with obstructive sleep apnea who are already using CPAP or BiPAP. It may help people feel more awake during the day without changing their sleep apnea device use.
Pittsburgh, PennsylvaniaAges 40–65 - NCT05919485Recruiting
Brain stimulation study for mild cognitive problems in Parkinson’s
This trial tests whether a type of noninvasive brain stimulation (tDCS) can improve thinking and memory in people with mild cognitive impairment in Parkinson’s disease. You may be eligible if you have these diagnoses, are on stable medications, and can safely complete brain scan/testing.
Antalya, AlanyaAges 45–80 - NCT05920109Recruiting
Early pain block to help breathing after severe chest trauma
This study tests whether an early pain-numbing injection to the chest wall can reduce how much ventilator support (breathing machine) people need after severe blunt chest injury with multiple rib fractures. If it works, it may help patients breathe more easily and spend less time on ventilation in the ICU.
BordeauxAges 18 years+ - NCT05920174Recruiting
Implant test to help movement in people with severe paralysis
This trial studies whether an implanted device that can record and stimulate brain signals is safe and may improve movement in people with motor disability from certain nerve or brain conditions. It’s for adults with stable, long-lasting paralysis and good brain function who can follow the study plan.
Beijing, Beijing MunicipalityAges 18–80 - NCT05919940Recruiting
Testing a muscle stimulation and extra protein plan in ICU patients
This trial tests whether electrical muscle stimulation plus extra protein (protein substitute) can improve muscle health and metabolism in critically ill adults in the ICU. If you’re newly admitted and expected to stay on a breathing machine for several days, it may help you keep more muscle strength during recovery.
Vienna, State of ViennaAges 18 years+ - NCT05920252Recruiting
Phone-based suicide risk support for teens in DBT
This trial tests whether a smartphone tool can help reduce suicide risk for teens who are already in an intensive therapy program (DBT). It may help you or your family recognize risk earlier and use skills more consistently between sessions.
New York, New YorkAges 13–18 - NCT05921214Recruiting
Testing how extra support helps young children learn words
This study looks at whether “extra support” during word learning helps children learn and use new words. It focuses on very young, English-speaking children who show lower word use for their age.
Tucson, ArizonaAges 2–4
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.