Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,462 recruiting studies in this area right now.
By phase
- Not applicable9,797
- Phase 2786
- Phase 1574
- Phase 3538
- Phase 4342
- Phase 1/Phase 2304
- Phase 2/Phase 3121
Top conditions
- Stroke854
- Parkinson Disease424
- Multiple Sclerosis342
- Alzheimer Disease340
- Dementia226
- Ischemic Stroke199
- Epilepsy196
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia152
- Traumatic Brain Injury152
- Sarcopenia148
- Acute Ischemic Stroke141
- Cerebral Palsy130
- Mild Cognitive Impairment129
- Pain Management114
- Migraine113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital134
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing95
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- Cairo University63
Where studies are running
- California675
- Massachusetts301
- New York292
- Florida277
- Texas267
- Maryland244
- Arizona216
- Alabama211
- Illinois193
- Pennsylvania177
Recruiting studies12,460 total
- NCT06559215RecruitingPhase 2
Pain management with Exparel after knee surgery in teens
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Frisco, TexasAges 13–21 - NCT06559241RecruitingPhase 3
Arm or leg cuff treatment for large clot stroke recovery
This trial tests whether a simple, non-invasive treatment (repeated inflation of a blood pressure cuff on your arm or leg) can help people recover better after a stroke caused by a large clot. You must be having a mechanical thrombectomy (clot removal) within 24 hours of your stroke.
Suzhou, AnhuiAges 18 years+ - NCT06559436Recruiting
Extending window for clot-busting drug in medium vessel stroke
This trial tests a clot-dissolving drug called tenecteplase given 4.5 to 24 hours after a stroke caused by a blockage in a medium-sized brain artery. It aims to see if waiting longer than usual still helps reduce disability.
Hefei, AnhuiAges 18 years+ - NCT06559475Recruiting
Testing a new aspiration catheter for large vessel stroke
This trial tests a new catheter (Super-Bore 8/7F) to remove blood clots in people having a major stroke caused by a blocked large artery in the brain. The goal is to see if it is safe and effective at restoring blood flow when used within 24 hours of stroke symptoms starting.
Hefei, AnhuiAges 18 years+ - NCT06559618RecruitingPhase 1
Phage therapy for bladder bacteria in spinal cord injury
This trial tests whether a special virus (bacteriophage) that attacks E. coli bacteria can help control bacteria in the bladder without causing an infection. It's for people with spinal cord injury who use a catheter and have E. coli in their urine but no active infection.
St Louis, MissouriAges 18 years+ - NCT06559956Recruiting
Comparing two ways to adjust Inspire therapy settings
This trial compares two methods of adjusting the Inspire device settings for sleep apnea. One method uses an overnight sleep study, the other a daytime study. The goal is to see if the daytime method works just as well.
Edegem, AntwerpAges 18–99 - NCT06559865Recruiting
Breathing exercises for concussion recovery in kids
This study tests whether slow, paced breathing exercises can help kids recover from a concussion. It looks at how the body's 'automatic' nervous system (which controls heartbeat, sweating, etc.) works after head injury.
Montreal, QuebecAges 9–18 - NCT06559969RecruitingPhase 2/Phase 3
IV vs Epidural Pain Medicine for Open Abdominal Surgery
This trial compares two ways to manage pain after major open abdominal surgery: giving pain medicine through an IV or through an epidural combined with numbing medicine. It aims to find which method works better for patients.
Iowa City, IowaAges 18–85 - NCT06560203Recruiting
Basilar artery stroke trial for later treatment
This trial tests if endovascular therapy (a procedure to remove a clot) can help people who have had a stroke in the back part of the brain (basilar artery) and can be treated within 72 hours, even if they are not eligible for clot-dissolving medicine. The treatment may improve recovery compared to standard care alone.
Beijing, Beijing MunicipalityAges 18–80 - NCT06560372Recruiting
Bleeding after head injury and brain blood vessel narrowing
This study looks at whether moderate to severe traumatic brain injury with bleeding around the brain can lead to a complication called cerebral vasospasm (narrowing of brain blood vessels). It's being done at Martinique University Hospital to understand how often this happens and how it affects recovery.
Fort-de-FranceAges 18 years+ - NCT06560736Recruiting
Anxiety help for teens with PKU
This study tests a brief therapy program designed to help teens with PKU manage anxiety or depression symptoms. It aims to see if this approach can prevent or treat these issues in this group.
Columbia, MissouriAges 10–17 - NCT06560983Recruiting
Blood sugar and stroke outcomes over one year
This study watches how blood sugar levels affect recovery and risks over one year in people who come to the ER with a stroke. It aims to help doctors better manage blood sugar during emergency stroke care.
Kathmandu, BagmatiAges 18 years+ - NCT06561100Recruiting
Optimizing treatment for brain-injured warfighters
This trial tests ways to improve treatment for active-duty service members who have had a mild traumatic brain injury (mTBI) and still have symptoms. It aims to find the best approach to help them recover.
Camp Pendleton, CaliforniaAges 18–55 - NCT06561919Recruiting
Speech and language study during brain stimulation treatment
This is an extra part of the STIMPulseControl study that focuses on speech. It looks at how the brain stimulation treatment affects your ability to speak clearly and communicate.
CologneAges 18–70 - NCT06561867RecruitingPhase 3
Comparing two drugs to prevent another stroke
This trial tests if ticagrelor or cilostazol is better at preventing a second stroke in people who have had their first mild to moderate ischemic stroke. It aims to find which treatment works best within the first 24 hours of symptoms.
Kafr ash ShaykhAges 18–75 - NCT06561906Recruiting
Early Alzheimer's detection using scans, genetics and blood
This study uses brain scans, blood tests, and genetic information to find early signs of Alzheimer's disease before memory problems start. It aims to predict who might develop Alzheimer's in the future.
Nanjing, JiangsuAges 50–79 - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT06562283Recruiting
Reproducibility of a fatigue test for spinal muscular atrophy
This study checks how consistent a fatigue test is for people with spinal muscular atrophy (SMA). It helps doctors better understand fatigue in SMA and may improve future care.
Saint-Etienne, FranceAges 6 years+ - NCT06562413Recruiting
Finding New Biological Clues in Hard-to-Treat Migraine
This study looks for new biological markers in people whose migraines don't respond to standard treatments. It aims to better understand why some migraines are hard to treat and may help guide future therapies.
PaviaAges 18–75 - NCT06562400Recruiting
New treatments for resistant migraine
This trial is testing new approaches for people whose migraines haven't improved with multiple preventive treatments. The goal is to find better options for those with hard-to-treat migraine.
PaviaAges 18–75 - NCT06563206Recruiting
Exergame and robotic therapy for stroke recovery
This study tests whether playing video games that involve movement (exergaming) or using a robotic arm device can help improve arm function and reduce inflammation after a stroke. It may be a good fit if you are ready to start therapy and can sit up and watch a screen.
Makassar, South SulawesiAges Any age - NCT06563414Recruiting
A study tracking eye scrapes in people with DEB
This study follows people with dystrophic epidermolysis bullosa (DEB) who get scrapes on the surface of their eye (corneal abrasions). It collects information to better understand how often and how severely these eye injuries happen.
Pittsburgh, PennsylvaniaAges 6 months+ - NCT06563817RecruitingPhase 2
Testing rapamycin for fluid buildup after a brain bleed
This trial tests whether the drug rapamycin can help people whose brain ventricles stay enlarged after a bleed, causing walking, memory, or bladder issues. If you qualify, you may receive rapamycin to see if it improves your symptoms and reduces fluid buildup.
Beijing, Beijing MunicipalityAges 18–70 - NCT06564662Recruiting
Brain wave test for kids with prolonged seizures
This study uses a quick brain wave test (EEG) to help doctors spot ongoing seizure activity in children who are thought to have status epilepticus, a type of long-lasting seizure. The results may help guide treatment faster.
The Bronx, New YorkAges 2–18
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,462 recruiting neurology studies from the U.S. registry right now, out of 19,649 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.