Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,497 recruiting studies in this area right now.
By phase
- Not applicable9,839
- Phase 2787
- Phase 1573
- Phase 3531
- Phase 4344
- Phase 1/Phase 2304
- Phase 2/Phase 3119
Top conditions
- Stroke856
- Parkinson Disease424
- Alzheimer Disease341
- Multiple Sclerosis341
- Dementia228
- Ischemic Stroke201
- Epilepsy196
- Insomnia156
- Obstructive Sleep Apnea155
- Traumatic Brain Injury154
- Spinal Cord Injuries151
- Sarcopenia149
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital135
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital69
- University of Minnesota63
Where studies are running
- California675
- Massachusetts305
- New York294
- Florida277
- Texas270
- Maryland245
- Alabama213
- Arizona211
- Illinois193
- Pennsylvania177
Recruiting studies12,495 total
- NCT03083405Enrolling by invitation
Study of tooth grinding during sleep
This study is for adults who have been diagnosed with sleep bruxism (tooth grinding during sleep). Researchers want to understand it better using sleep testing, and it may help refine how this condition is evaluated.
WroclawAges 18–70 - NCT02914951Enrolling by invitation
Therapy to reduce irritability in children with autism
This trial studies whether cognitive-behavioral therapy (a structured talk therapy) can reduce irritability and anger outbursts in children with autism. It may help improve day-to-day behavior by teaching coping skills and reducing problem reactions.
New Haven, ConnecticutAges 8–16 - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT02564692Enrolling by invitation
APOE gene testing registry to find Alzheimer’s prevention studies
This program enrolls people to get a gene test (APOE) so researchers can match you to Alzheimer’s prevention studies in the future. If you qualify, you do the test but you would not receive your gene test results.
Phoenix, ArizonaAges 50–90 - NCT02553525Enrolling by invitation
Testing different stimulation patterns in Parkinson’s, tremor, and MS
This study tests whether changing the “stimulation pattern” in a deep brain stimulator can improve how well symptoms are controlled. If you are already getting (or replacing) a deep brain stimulator, this may help fine-tune the settings for you.
Gainesville, FloridaAges 21–80 - NCT02402426Enrolling by invitation
Online brain health registry for adults
This study is building an online registry where adults can share information to help researchers find people for future brain research. Joining may help future studies get the people they need.
San Francisco, CaliforniaAges 18 years+ - NCT02725060Enrolling by invitation
Study of autoimmune changes in postural tachycardia syndrome
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
Oklahoma City, OklahomaAges 18–50 - NCT02422875Enrolling by invitation
Study of immune markers in autoimmune disease and lupus
This study looks at blood and immune cell markers (autoantibodies and immune cell “signatures”) to better understand autoimmune conditions, including lupus. It may help researchers identify which markers are linked to disease and how immune cells respond after vaccination.
Atlanta, GeorgiaAges 18 years+ - NCT02630589Recruiting
Brain implant for severe one-sided ringing that harms daily life
This trial tests an implant that sends sound signals to the brainstem to reduce severe ringing in one ear. It may help people whose one-sided tinnitus has lasted over a year and did not improve with usual treatments like hearing aids and CBT.
GroningenAges 18 years+ - NCT02463708Enrolling by invitation
Caregiver program study for people with memory problems
This study tests a caregiver support program (PACE/PACENET BHL Caregiver Program) and looks at outcomes over several months. It’s for caregivers of adults with clinically significant memory/cognitive problems, using some past clinical information and follow-up reports.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02769416Enrolling by invitation
Testing new treatments for spinal cord and brain injuries
This study looks for ways to test treatments for people with spinal cord injuries and/or brain injuries. It may help researchers better understand which treatment approaches work and for whom.
Houston, TexasAges 18 years+ - NCT02414178Enrolling by invitation
Tau PET brain scan for inherited Alzheimer’s disease
This study uses a special brain scan to measure “tau” buildup in people with an inherited form of Alzheimer’s. It may help researchers better understand disease changes and evaluate whether the scan can track them over time.
St Louis, MissouriAges 18 years+ - NCT02413450Enrolling by invitation
Using patient DNA cells to study inherited heart rhythm risks
This study uses your blood or genetic information to make “iPS cells,” lab-grown cells that can help researchers study inherited heart rhythm problems like LQTS, Brugada syndrome, CPVT, or early repolarization syndrome. It may help improve understanding of why these rhythms happen and guide future treatments.
Baltimore, MarylandAges 18–85 - NCT02621944RecruitingEarly Phase 1
Melatonin for newborns with brain injury after oxygen problems
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
Gainesville, FloridaAges Up to 6 hours - NCT02151175Enrolling by invitation
Focused ultrasound to treat medication-resistant temporal lobe seizures
This trial tests a low-intensity focused ultrasound treatment aimed at reducing seizures caused by problems in one side of the hippocampus (a brain area involved in memory and seizures). It’s for people whose seizures have not responded to several seizure medicines and who have been offered a specific type of surgery.
Los Angeles, CaliforniaAges 18–60 - NCT02260271Enrolling by invitation
Study for newborns with severe oxygen-related brain injury
This trial is for newborn babies who had an oxygen shortage around birth and now have severe brain injury. It aims to test approaches that may help improve outcomes after this kind of early-life brain damage.
Gainesville, FloridaAges 1 day–3 weeks - NCT01902407Enrolling by invitation
Sleep scan study using computer models in people with Down syndrome
This study uses computer simulations to understand breathing airways and lung changes during sleep in people with Down syndrome. It may help researchers better interpret sleep MRI/CT scans and improve how sleep apnea (OSA) is studied in the future.
Cincinnati, OhioAges 1–90 - NCT01803906Enrolling by invitation
Tissue sample study for suspected mitochondrial disorders
This study collects tissue samples to help researchers learn more about mitochondrial disorders—conditions related to how the body makes energy. It may help by improving genetic understanding for families who suspect an inherited cause.
New York, New YorkAges Any age - NCT01759225Enrolling by invitation
Registry study of people with heart and blood vessel disease
This is a registry (a study that collects health information) for people with certain heart and blood vessel conditions. It may help researchers better understand who has these diseases, how they are managed, and outcomes over time.
Tel AvivAges Any age - NCT00870129Recruiting
MRI mapping to plan radiation for certain brain tumors
This study uses MRI scans to find higher-risk areas in certain brain and other solid tumors and help plan radiation treatment. It also looks for changes in tumor “metabolites” (chemicals in the tumor) that may relate to how the tumor behaves.
New York, New YorkAges 18 years+ - NCT00704626Enrolling by invitation
Blood antibody tests in autoimmune brain and nerve diseases
This study looks at blood “auto-antibodies,” which are immune proteins that may attack the body, in people with certain brain and nerve conditions. It may help researchers better understand these diseases and how the immune system is involved.
Sacramento, CaliforniaAges 18 years+ - NCT02051062Enrolling by invitationPhase 4
Blood-plasma study of botulism antitoxin in children
This trial studies how a botulism antitoxin (called BAT, heptavalent) moves through the body in children. It may help doctors better choose doses and timing for pediatric treatment by learning from blood samples after the first dose.
Ages 1 day–11 years - NCT00950430Enrolling by invitationPhase 4
Brain scan study for amyloid plaques in adults
This study uses brain imaging to look for amyloid plaques (abnormal protein deposits) as people age. It may help researchers better understand how these changes develop over time.
Rochester, MinnesotaAges 30–100 - NCT00859794Enrolling by invitation
Study brain and movement functions in people with difficult epilepsy
This study looks at how the brain and body coordination work in people with epilepsy whose seizures do not fully respond to seizure medicines. Some participants may be people who are being evaluated for a possible epilepsy surgery because tests suggest they could benefit.
Great Neck, New YorkAges 5 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,497 recruiting neurology studies from the U.S. registry right now, out of 19,911 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.