Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,406 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2783
- Phase 1576
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3124
Top conditions
- Stroke841
- Parkinson Disease427
- Alzheimer Disease342
- Multiple Sclerosis341
- Dementia227
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Insomnia154
- Spinal Cord Injuries153
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment130
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida275
- Texas265
- Maryland246
- Arizona212
- Alabama210
- Illinois188
- Pennsylvania177
Recruiting studies12,404 total
- NCT06730542RecruitingPhase 1
Zanubrutinib plus pola-R-CHP and high-dose methotrexate for secondary CNS lymphoma
This trial tests a combination of targeted therapy (zanubrutinib) plus a standard chemo-immunotherapy regimen (pola-R-CHP) and high-dose methotrexate for people whose large B-cell lymphoma has spread to the brain or spinal cord. The goal is to see if this approach can effectively treat lymphoma in both the body and the central nervous system.
Miami, FloridaAges 18 years+ - NCT07263425RecruitingPhase 2
Study of thiotepa and trastuzumab for breast cancer that spread to the lining of the brain and spinal cord
This trial tests a combination of two drugs given through a special port in the head to treat HER2-positive breast cancer that has spread to the layer covering the brain and spinal cord (leptomeningeal metastasis). It aims to see if this treatment is safe and effective.
Nanjing, JiangsuAges 18–75 - NCT06866028Recruiting
Brain training to improve emotion regulation using fNIRS feedback
This trial uses a brain imaging technique called fNIRS (a safe, non-invasive headband) to give you real-time feedback on your brain activity. The goal is to help you learn to improve your emotion regulation. It may be helpful if you have no major mental health conditions and want to try a new way to manage emotions.
Hong KongAges 18–30 - NCT07012668Recruiting
Treatments for heart-brain conditions and post-surgery stroke
This trial is studying different treatments for people who have conditions that affect both the heart and brain, or who have had a stroke or other brain blood vessel problem after heart surgery. The goal is to find out which treatments work best and see what factors affect the results.
BeijingAges 18 years+ - NCT06718933RecruitingPhase 1/Phase 2
Study of a drug combination for breast cancer that spread to the brain
This trial tests whether a combination of three drugs (SHR-A1811, pyrotinib, and bevacizumab) can help people with advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and stop them from growing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07010887Recruiting
Soccer heading and your brain
This study looks at how different intervals of heading a soccer ball affect your brain health. You might be eligible if you're a current soccer player with several years of heading experience and no recent head or eye problems.
Bloomington, IndianaAges 18–35 - NCT06736925Recruiting
Omega-3 fish oil and soccer heading study
This study tests whether taking omega-3 fatty acids (fish oil) can help protect your brain from the effects of repeated, minor head impacts from soccer heading. If you are a soccer player aged 18-30, you may be able to join.
Bloomington, IndianaAges 18–30 - NCT07365553Recruiting
Omega-3 for autism in children and teens
This trial tests whether omega-3 supplements can help children and teens with autism spectrum disorder (ASD). It aims to see if taking omega-3 improves core symptoms like social communication and behavior.
Taichung, TaichungAges 6–17 - NCT06868511RecruitingPhase 3
Minimally invasive clot removal with tenecteplase for deep brain bleed
This trial tests a minimally invasive procedure to remove deep brain bleeds using a special puncture guided by brain imaging, combined with a clot-dissolving drug called tenecteplase. It may help reduce damage from the bleed and improve recovery.
Beijing, ChinaAges 18–80 - NCT07003139RecruitingPhase 1/Phase 2
BNCT for High-Grade Malignant Brain Tumors
This trial tests a special type of radiation therapy called boron neutron capture therapy (BNCT) for people with high-grade malignant brain tumors. It aims to see if BNCT is safe and effective for tumors that have not been treated or have come back after standard treatments.
HsinchuAges 18 years+ - NCT06811675RecruitingPhase 4
Preventing brain damage after carbon monoxide poisoning
This trial tests if combining two common medicines, dexamethasone and N-acetylcysteine, can help prevent long-term brain problems in people who have been poisoned by carbon monoxide.
TaichungAges 18 years+ - NCT06998368Recruiting
Calcium channel, sleep, and 5G brain health study
This study tests whether a common genetic variation in calcium channels affects how 5G mobile signals influence sleep and brain health. It involves taking a medication (nimodipine) and sleeping in a lab.
Zurich, Canton of ZurichAges 20–40 - NCT06997354Recruiting
Parent survey to screen children for vision brain problems
This trial is testing a questionnaire for parents to help spot signs of vision problems in children that come from how the brain processes sight, not from the eyes themselves. It aims to make early detection easier for families and doctors.
Louvain-la-NeuveAges 3 years+ - NCT06715449RecruitingPhase 2/Phase 3
Testing empagliflozin after a stroke with unknown cause
This trial tests if a diabetes drug called empagliflozin can help the heart's left atrium work better in people who have had a stroke with no known cause. You may join if you are getting a heart monitor device implanted to look for hidden irregular heartbeats.
Cambridge, CambridgeshireAges 18 years+ - NCT06996028Recruiting
Lift and pedals for balance and movement in children with CP
This study tests if doing lifting and pedaling exercises helps children with cerebral palsy improve their balance and ability to move around. It may be a good fit if your child can walk without much help and follow simple instructions.
Lahore, Punjab ProvinceAges 6–12 - NCT07202143RecruitingPhase 3
Steroid treatment for severe stroke with low lymphocyte count
This trial tests if the steroid methylprednisolone helps people who have had a major stroke and also have low infection-fighting white blood cells (lymphocytes). It is for patients who are getting a procedure to remove the clot (thrombectomy) within 24 hours of the stroke.
Fuzhou, FujianAges 18 years+ - NCT05824338RecruitingEarly Phase 1
Testing ropivacaine spinal anesthesia for lower back surgery
This early study tests whether using ropivacaine (a local numbing medicine) in spinal anesthesia is safe and workable for certain lower back operations. If you qualify, it may help doctors refine anesthesia choices for your type of surgery.
New Westminster, British ColumbiaAges 19–80 - NCT03988283RecruitingPhase 1
Personalized DNA vaccine for recurrent childhood brain tumors
This trial tests a personalized DNA vaccine made from your tumor’s DNA (neoantigens) to help your immune system fight the cancer. It is designed for children and young adults with certain recurrent or newly diagnosed brain/spine tumors, after they have had other standard treatments and tumor tissue is available for testing.
St Louis, MissouriAges Up to 25 years - NCT07727239Recruiting
Brain stimulation trial for people with narcolepsy type 1
This trial tests a non-invasive brain stimulation method called temporal interference to target the hypothalamus. It aims to help reduce excessive daytime sleepiness in people with narcolepsy type 1.
Xi'an, ShaanxiAges 12–60 - NCT06762249Enrolling by invitation
Combined therapy for arm recovery after stroke
This trial tests combining two rehabilitation methods (CIMT and Brunnstrom therapy) to help people who have had a stroke improve arm and hand function on their affected side.
Multan, Punjab ProvinceAges 40–70 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85 - NCT06970639RecruitingPhase 3
Study comparing new targeted drug plus chemo vs osimertinib for lung cancer with brain tumors
This trial tests a new targeted therapy called furmonertinib combined with chemotherapy against the current standard osimertinib for people with a specific type of non-small cell lung cancer (NSCLC) that has spread to the brain. It aims to find a better treatment option for patients whose cancer cells have a common EGFR mutation.
Guangdong, GuangzhouAges 18 years+ - NCT07690514Recruiting
Ultrasound treatment for cervical dystonia
This study tests a new type of ultrasound treatment for cervical dystonia (neck muscle spasms). It uses focused sound waves to target the brain areas causing the condition, and aims to see if it can reduce symptoms without surgery.
Toronto, OntarioAges 18–90 - NCT06706674RecruitingPhase 3
Testing lumateperone for irritability in teens with autism
This study tests an investigational medication called lumateperone to see if it can reduce irritability in children and teens with autism. It is for teenagers aged 13–17 whose irritability is causing significant problems.
Little Rock, ArkansasAges 5–17
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,406 recruiting neurology studies from the U.S. registry right now, out of 19,323 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.