Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,406 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2783
- Phase 1576
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3124
Top conditions
- Stroke841
- Parkinson Disease427
- Alzheimer Disease342
- Multiple Sclerosis341
- Dementia227
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Insomnia154
- Spinal Cord Injuries153
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment130
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida275
- Texas265
- Maryland246
- Arizona212
- Alabama210
- Illinois188
- Pennsylvania177
Recruiting studies12,404 total
- NCT05918679Recruiting
Study of brain activity during learning speech sounds
This study looks at how the brain helps you learn and produce speech, especially the “motor” skills involved in making speech sounds. You may be able to take part if you’re healthy and meet the language, hearing, and medication requirements.
Tempe, ArizonaAges 18 years+ - NCT06967922Recruiting
Cognitive behavior therapy for acute insomnia
This trial tests if a specific type of talking therapy called analytic-integrative cognitive behavioral therapy can help people with new-onset insomnia (trouble sleeping for less than 3 months). It aims to improve sleep quality and reduce stress related to sleep problems.
BeijingAges 18 years+ - NCT07439367Recruiting
Brain stimulation to improve arm movement after stroke
This study tests a new type of non-invasive brain stimulation to help people with arm weakness after a stroke improve their movement and daily function.
Carouge, Canton of GenevaAges 18 years+ - NCT06610682RecruitingEarly Phase 1
Plixorafenib for BRAF-mutated glioma
This study tests a new targeted drug called plixorafenib, either alone or combined with another drug (retifanlimab), for people with a BRAF-mutated brain tumor. The goal is to see if the drug can reach the brain and control the tumor, while checking for side effects.
Baltimore, MarylandAges 18 years+ - NCT06957912Recruiting
Ear nerve stimulation for recovery after major surgery
This trial tests if stimulating a nerve in your ear (vagus nerve) before and after noncardiac surgery can improve your recovery. It's for adults aged 18 to 84 having planned or time-sensitive surgery lasting at least 2 hours.
Beijing, Beijing MunicipalityAges 18–85 - NCT06958289Recruiting
Cold therapy for muscle tightness: long-term effects and brain changes
This study tests if freezing a nerve (cryoneurolysis) can reduce muscle tightness (spasticity) and improve arm movement. It also looks at how the brain may change after treatment. If you have tight muscles that improved with a numbing nerve block, you may be eligible.
London, OntarioAges 18 years+ - NCT03276793Recruiting
Brain connectivity study in people with depression
This study looks at brain “connectivity” (how different brain areas talk to each other) in people with depression. You may be able to join if you are already getting once-daily TMS to a specific brain area at Brigham and Women’s or Massachusetts General, and you can safely complete MRI scans.
Boston, MassachusettsAges 18 years+ - NCT07059286Enrolling by invitation
Pregnancy, Baby Brain Scans, and Child Development Study
This study looks at how a mother's health and experiences during pregnancy may affect her baby's brain growth and early development. You and your baby would have special MRI brain scans, fill out some questionnaires, and then your child's development would be followed until they are 6 years old.
Milan, MIAges 18 years+ - NCT05734625RecruitingPhase 2
Nerve block injections for episodic migraine pain relief
This Phase 2 trial tests whether nerve block injections can reduce pain from episodic migraines. It may help some people who get frequent migraine attacks but are not also using certain migraine preventions or strong pain medicines.
Rochester, MinnesotaAges 18 years+ - NCT07057245Recruiting
Protein supplement and brain function in older adults
This study tests whether taking a daily protein supplement can improve how your brain works. It is for healthy older adults (ages 60–75) who are overweight but do not have diabetes or take certain medications.
Maastricht, LimburgAges 60–75 - NCT07265596RecruitingPhase 2
Brain Scan Study for Early Parkinson's Disease
This trial uses a special brain scan (PET scan) to look at early changes in people who have early signs of Parkinson's disease. The goal is to learn more about how Parkinson's develops over time.
New Haven, ConnecticutAges 18 years+ - NCT06081218Recruiting
Exercise and brain function in cannabis users
This study looks at how a single session of exercise affects brain function and memory in regular cannabis users compared to non-users. You will exercise on a bike or watch a movie, and then do memory tests and a blood draw.
LilleAges 18–35 - NCT07245615Recruiting
Vibration therapy for neck dystonia
This study tests whether a gentle vibration device placed on the neck can improve head posture in people with cervical dystonia (neck muscle spasms). The goal is to find the best vibration strength to help reduce symptoms.
Minneapolis, MinnesotaAges 30 years+ - NCT06948136RecruitingPhase 1
THC effects in older adults trial
This trial studies how a single dose of THC (the active ingredient in cannabis) affects older adults. It aims to understand the effects in this age group, which may help guide safe use.
West Haven, ConnecticutAges 21 years+ - NCT06946407Recruiting
Chemotherapy combination for brain lymphoma
This trial tests a combination of chemotherapy drugs to treat lymphoma that started in your brain. The goal is to see if this treatment helps without having to use whole-brain radiation.
ChangchunAges Up to 60 years - NCT07288840Enrolling by invitation
Exercise plan for heart recovery monitored by heart rate
This study tests a special exercise program for people with heart disease or heart failure. The goal is to see if the exercises can help improve how your heart responds to activity and daily life.
Leiria, Leiria DistrictAges 18 years+ - NCT06739434Enrolling by invitation
Gene therapy for Rett syndrome in girls
This trial tests a new gene therapy called GCB-002 for girls with Rett syndrome caused by a MECP2 gene change. It may help improve symptoms by targeting the root genetic cause.
Shanghai, Shanghai MunicipalityAges 2–10 - NCT06942611Recruiting
Electrical brain stimulation for chronic pain from nerve inflammation
This study tests a noninvasive brain stimulation technique (transcranial electrical stimulation) to see if it can reduce chronic pain in people with conditions like multiple sclerosis or neuromyelitis optica. It aims to offer a new, drug-free option for pain relief without major side effects.
BeijingAges 18–65 - NCT05393622Recruiting
Brain stimulation trial for severe, treatment-resistant depression
This study tests an implanted form of brain stimulation for people with severe depression that has not improved with multiple medication trials. If you qualify, you would have brain scans and surgery planning, then follow a treatment-and-safety plan for several months.
Boston, MassachusettsAges 21–80 - NCT06943742Recruiting
Brain scan without helium for children with brain tumors
This study uses a special type of brain scan (magnetoencephalography, or MEG) that doesn't need helium gas to see brain activity in children with brain tumors. The goal is to see if this scan can help doctors plan surgery or treatment better.
Guangzhou, GuangdongAges 3–18 - NCT06937931RecruitingPhase 2
Study of IPN10200 for neck muscle spasms in adults
This trial tests a new botulinum toxin medication (IPN10200) for adults with cervical dystonia, a condition that causes painful muscle spasms in the neck and shoulders. It aims to see if the treatment is safe and effective in reducing symptoms.
Tucson, ArizonaAges 18–80 - NCT06367608Recruiting
Focused ultrasound for task-specific hand dystonia
This trial tests a new way to treat severe hand cramps that happen only when you do a specific task (like writing or playing an instrument). It uses focused ultrasound to precisely target a small area in the brain to calm the unwanted movements.
Baltimore, MarylandAges 21–75 - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
Birmingham, AlabamaAges 18 years+ - NCT06884553Recruiting
Robotic arm therapy vs. standard therapy for chronic stroke
This study compares two types of arm therapy for people who had a stroke at least 6 months ago: one using a robotic device and the other using standard occupational therapy (exercises with a therapist). The goal is to see which helps more with arm movement and function.
Florence, ItalyAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,406 recruiting neurology studies from the U.S. registry right now, out of 19,323 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.