Ophthalmology
Eyes & vision clinical trials
Eye disease and conditions that affect sight. We’re tracking 1,760 recruiting studies in this area right now.
By phase
- Not applicable1,199
- Phase 3133
- Phase 2119
- Phase 1117
- Phase 492
- Phase 1/Phase 286
- Phase 2/Phase 314
Top conditions
- Glaucoma107
- Myopia88
- Cataract76
- Diabetic Retinopathy51
- Dry Eye38
- Keratoconus34
- Retinitis Pigmentosa33
- Age-Related Macular Degeneration31
- Amblyopia26
- Eye Diseases24
- Graves Disease24
- Sjogren's Syndrome24
- Dry Eye Disease (DED)23
- Multiple Sclerosis22
- Astigmatism21
- Ocular Hypertension21
- Diabetic Macular Edema20
- Macular Degeneration20
Leading sponsors
- Zhongshan Ophthalmic Center, Sun Yat-sen University25
- Medical University of Vienna20
- Second Affiliated Hospital, Zhejiang University, School of Medicine19
- Fondation Ophtalmologique Adolphe de Rothschild18
- Assistance Publique - Hôpitaux de Paris16
- The Hong Kong Polytechnic University16
- Eye & ENT Hospital of Fudan University15
- National Eye Institute (NEI)15
- National Taiwan University Hospital15
- Shanghai Eye Disease Prevention and Treatment Center15
Where studies are running
- California133
- Arizona69
- Florida43
- Maryland39
- Texas37
- Massachusetts35
- New York35
- Alabama26
- North Carolina20
- Pennsylvania20
Recruiting studies1,760 total
- NCT06047717Recruiting
Virtual reality navigation study for stroke survivors
This study uses virtual reality to understand how vision loss from a stroke affects navigation. You may help researchers learn more by wearing a VR headset and doing simple tasks.
Rochester, New YorkAges 21–75 - NCT03161652RecruitingPhase 2
Levosulpiride for diabetic eye swelling and retinopathy
This Phase 2 study tests whether levosulpiride can improve changes in the retina in people with diabetic retinopathy and diabetic macular edema (eye swelling that can affect vision). It may help by targeting chemicals in the body that could affect eye tissue and inflammation.
Querétaro City, QuerétaroAges 40–69 - NCT04129021Recruiting
Eye imaging test with fast detailed scans
This trial studies whether a new, very high-resolution and high-speed eye scan can be used for people with eye problems or for healthy volunteers. It may help doctors better “see” eye structures more clearly to guide care.
ParisAges 18 years+ - NCT05989620Recruiting
Long-term study of muscular dystrophy functions
This study tracks changes in muscle strength and breathing over time in people with certain types of muscular dystrophy. It helps researchers develop better tests to measure how the disease progresses.
Richmond, VirginiaAges 6–50 - NCT06013462Recruiting
Corneal transplant after earlier eye surgery
This trial tests a type of corneal transplant (DMEK) in people who have had previous eye surgeries, such as vitrectomy or glaucoma surgery. It aims to see if the transplant works well even in these complicated cases.
ParisAges 18 years+ - NCT06023550Recruiting
Complicated Ear, Nose, and Throat Infections Study
This study looks at patients with complicated infections of the ear, nose, throat, or neck that are treated at a specific hospital in Slovenia. The goal is to learn more about these infections and how they are managed.
Ljubljana, LjubljanaAges Any age - NCT06022029RecruitingPhase 1
Study of injected ONM-501 alone or with cemiplimab for advanced cancers
This trial tests an injected study drug (ONM-501) alone or with another drug (cemiplimab) for people with advanced solid tumors or lymphomas that haven't responded to other treatments. It aims to find a safe dose and see if the combination helps shrink or control the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT05986864RecruitingPhase 1/Phase 2
Gene therapy injection for wet AMD
This study tests a new gene therapy injection called SKG0106 for people with wet AMD. The treatment is given as an injection into the eye and aims to reduce the need for frequent anti-VEGF shots.
St. Petersburg, FloridaAges 50 years+ - NCT05982925Recruiting
Brain imaging study in multiple sclerosis
This study uses MRI scans to look at how multiple sclerosis affects the outer layer of the brain over time. It aims to learn more about the disease to help improve future treatments.
New York, New YorkAges 18 years+ - NCT05426044RecruitingPhase 2
Metformin to protect the optic nerve in glaucoma
This study tests whether metformin can slow damage to the optic nerve in people with glaucoma. It uses eye scans and vision tests to look for changes over time, aiming to help preserve sight.
Wong Chuk HangAges 18 years+ - NCT05954403Recruiting
Eye birth defect study from newborns to adults
This is a national study that follows people with certain rare eye birth defects and their families, including pregnant people. It aims to better understand how often related health issues happen and to study inheritance (DNA) in families.
Paris, Île-de-France RegionAges Any age - NCT05954416Recruiting
Study follow-up for rare skin and related genetic conditions
This study (a “cohort”) follows people with certain rare skin conditions over time. It helps doctors better understand these diseases and improve long-term care, and you may be asked to complete surveys.
BobignyAges Any age - NCT05955638Enrolling by invitation
Dual-focus contacts to slow worsening near-sightedness
This study tests whether dual-focus soft contact lenses can help slow how quickly myopia (near-sightedness) gets worse in young university students. You may be assigned either the dual-focus lens or a control lens, and you would need to wear the lenses most days for set hours.
Bradford, West YorkshireAges 18–21 - NCT05959005Recruiting
Tracking early macular atrophy changes in the eye
This study focuses on people age 50+ with early “wasting away” changes in the macula (central retina) called atrophic lesions. It aims to better understand how these early changes progress and how they affect vision testing, which may help improve future treatments.
Salt Lake City, UtahAges 50 years+ - NCT05966467Recruiting
Patient registry for AQP4+ neuromyelitis optica on C5 inhibitors
This registry collects health and relapse information from adults with AQP4-positive NMOSD who are taking C5-blocking medicines to prevent long-term relapses. It helps researchers better understand treatment patterns and outcomes in real-world care.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05955846Recruiting
Testing a new cataract lens with a virtual aperture
This trial tests a specific cataract replacement lens to see how safe it is and how well it improves vision. If you have cataracts in both eyes and are good candidate for cataract surgery, this lens may help you see more clearly after surgery.
CoimbraAges 40–75 - NCT05932069Recruiting
Exercise program for intermediate age-related eye disease
This study tests whether an active (aerobic) exercise program can improve day-to-day function in Veterans with intermediate age-related macular degeneration (AMD). To join, you must have the right type stage of AMD, be able to do the assessments and exercise, and meet health and internet needs.
Decatur, GeorgiaAges 65–89 - NCT05921162Enrolling by invitation
Long-term follow-up after a vision gene eye injection
This study checks how people who previously received a gene therapy eye injection (vMCO-I) are doing over the long term. It may help researchers understand long-lasting effects and safety.
Cuttack, OdishaAges 18 years+ - NCT05924477Recruiting
Compare glaucoma shunt options to prevent cell loss
This study compares a glaucoma drainage device approach to see which one better prevents loss of corneal cells after surgery. You may benefit by receiving close monitoring around the time of glaucoma surgery and helping doctors improve surgical choices.
San Francisco, CaliforniaAges 18 years+ - NCT05913063Recruiting
Testing how the eye responds to tiny quantum states
This study looks at how the human eye detects very small “quantum” information. It compares people with certain vision conditions to people with normal vision to see how the eye’s macula and overall vision are involved.
Hong Kong, GuangdongAges 18 years+ - NCT05940623Recruiting
Home eye pressure monitoring for glaucoma
This study tests whether measuring your eye pressure at home with a special device can help control glaucoma and slow its progression. It may offer a more convenient way to track your condition between doctor visits.
Wong Chuk HangAges 18 years+ - NCT05893654Enrolling by invitationPhase 1/Phase 2
Melphalan treatment to shrink eye melanoma before other therapy
This early-phase study tests whether melphalan can be used to reduce (shrink) a type of eye cancer called choroidal melanoma before additional treatment. It may help by controlling tumor size while doctors closely monitor the eye and outcomes.
Ribeirão Preto, São PauloAges 18 years+ - NCT05878860RecruitingPhase 3
Gene therapy for X-linked retinoschisis
This trial tests a gene therapy called ATSN-201 for people with X-linked retinoschisis (XLRS), a condition that affects the retina and can cause vision loss. The therapy aims to fix the faulty gene that causes the condition, potentially halting vision loss and improving vision. Participants receive a one-time injection into the eye, and the study monitors safety and effectiveness.
Phoenix, ArizonaAges 5 years+ - NCT05885022Recruiting
Testing a glaucoma device during eye surgery planning
This study checks whether the Calibreye System can be used safely and effectively for people with certain types of glaucoma. It may help doctors better assess the eye before treatment, especially for selecting the right surgical approach.
ChennaiAges 18 years+
Common questions
- How many eyes & vision clinical trials are recruiting?
- Clin2 is tracking 1,760 recruiting ophthalmology studies from the U.S. registry right now, out of 2,756 we cover in this area in total.
- What does “Eyes & vision” cover here?
- Eye disease and conditions that affect sight. We group each study into eyes & vision based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a eyes & vision trial near me?
- Use the search to filter eyes & vision studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.