Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07371793RecruitingPhase 1/Phase 2
Study of BBI-001 for healthy people and those with iron overload
This trial tests an experimental drug called BBI-001. It first looks at safety in healthy volunteers, then tests whether it can help people with hereditary hemochromatosis, a condition where the body stores too much iron.
Sydney, New South WalesAges 18–70 - NCT07372027Recruiting
Single-needle return for long-lasting dialysis access
This study compares a new single-needle return technique for your dialysis access (AVF) to the usual two-needle method. It aims to see if using just one needle on your fistula and getting the blood back through a leg vein can help your fistula last longer.
Suzhou, AnhuiAges 18–100 - NCT07372898Recruiting
Helping parents create a calm home for preterm babies after surgery
This study tests a program called H-HOPE that helps parents create a calm, supportive environment for their baby after major surgery. The goal is to improve the baby's recovery and reduce stress for the whole family.
Chicago, IllinoisAges 1 week–2 months - NCT07373639Recruiting
Long-term follow-up after BEAM-101 treatment
This study is for people who have already received BEAM-101 in a previous study. It simply follows them over time to track their health and any long-term effects.
Birmingham, AlabamaAges 14–37 - NCT07373821Recruiting
Lying face up after cornea transplant surgery
This study tests if lying face up after DMEK surgery (a cornea transplant for Fuchs dystrophy) helps the surgery work better. It may be an option for people with Fuchs dystrophy or bullous keratopathy who can lie flat on their back.
HeidelbergAges Any age - NCT07374263Recruiting
Do heart rhythm drugs pose risks in hospital?
This study looks at whether certain medications that can affect heart rhythm (QT-prolonging drugs) are linked to serious heart problems in adults who were hospitalized. It includes patients admitted to St. Joseph's Healthcare Hamilton or other GEMINI hospitals between 2017 and 2025.
Hamilton, OntarioAges 18 years+ - NCT07374354Recruiting
Pain and anxiety control for kids with MIH
This study tests a pain-relieving medicine given before dental treatment to see if it helps reduce pain and anxiety in children with molar incisor hypomineralization (MIH), a condition that causes weak enamel on molars and front teeth.
GizaAges 6–12 - NCT07375940Recruiting
Understanding Behçet Disease in children and teens
This study looks at the health records and blood tests of children and young adults with Behçet disease to learn more about the condition. It also compares their results with healthy children to find clues that may help doctors better understand and treat Behçet disease.
Florence, FlorenceAges 6 months–70 years - NCT07377162Recruiting
Hyperoxia effects on brain blood flow in ICU patients
This trial studies how giving extra oxygen (hyperoxia) affects blood flow in the brain for patients on a breathing machine in the intensive care unit. The goal is to see if short bursts of higher oxygen levels are safe and how they change brain activity.
BrusselsAges 18 years+ - NCT07378423Recruiting
Survey on signs of cancer at birth
This trial asks newly diagnosed children and young adults with certain types of cancer to fill out a questionnaire about signs of cancer present at birth. The answers may help improve early detection of childhood cancer.
BernAges Up to 21 years - NCT07378553Recruiting
Ultrasound markers for Duchenne and Becker muscular dystrophies
This study uses a new type of ultrasound scan to look at muscle health in people with Duchenne or Becker muscular dystrophy. It aims to find better ways to track the disease over time.
NantesAges 5–60 - NCT07381413Recruiting
Eye tracking study for thyroid eye disease
This study uses eye tracking to compare how people with thyroid eye disease move their eyes and pay attention to visual cues. It may help researchers understand eye movement problems better.
ShanghaiAges 18–70 - NCT07382128Recruiting
Heart MRI to Understand Hypertrophic Cardiomyopathy
This trial uses a special heart MRI to better understand different types of hypertrophic cardiomyopathy (thick heart muscle). It may help doctors tell apart various forms of the condition and guide treatment.
Bologna, BOAges 18 years+ - NCT07385443Recruiting
Spanish registry for myotonic dystrophy type 1
This registry collects information from people with myotonic dystrophy type 1 (DM1) to better understand the condition and improve care. Anyone with a confirmed genetic diagnosis can join.
Multiple Locations, AndalusiaAges Any age - NCT07388966Recruiting
Monitoring limb movement in skeletal dysplasia
This study tracks how people with achondroplasia or hypochondroplasia move their arms and legs over time. It uses a small wearable device to measure movement and may help doctors understand daily mobility better.
ParisAges 3–65 - NCT07389343Recruiting
Semi-rigid foot insole for flat feet without pain
This study tests whether a semi-rigid shoe insert can help young adults with flexible flat feet that are not painful. If you have flat feet but not constant pain, this trial may help improve foot function.
GizaAges 18–35 - NCT07390240Recruiting
Study of ALPL gene variants in hypophosphatasia in Russia
This study looks at how changes in the ALPL gene affect the natural course of hypophosphatasia (HPP). It aims to learn more about the condition in people who have not received enzyme replacement therapy.
MoscowAges Any age - NCT07390318Recruiting
Bowel continence study for people with spina bifida
This study looks at how bowel management enema programs work for people with spina bifida (a type of spinal cord condition). It aims to improve continence and quality of life.
Birmingham, AlabamaAges 5 years+ - NCT07392216Recruiting
Ovarian health in young women with sickle cell disease
This study looks at how sickle cell disease might affect the ovaries (the organs that store eggs) in girls and young women. It compares participants with sickle cell disease to healthy females of similar age and background.
Memphis, TennesseeAges 10–18 - NCT00556530Recruiting
Study genes and severity in 22q11.2 deletion
This study looks at how genetic differences affect how severe 22q11.2 deletion syndrome is for different people. It may help researchers understand what drives symptom severity and guide future care.
New York, New YorkAges Any age - NCT00018889Recruiting
Understanding Movement Disorders Through Genetics and Traits
This research study helps scientists understand how genes and family traits connect to movement disorders like Parkinson's disease or tremor. You may be asked to answer questions about your symptoms, provide family history, and possibly have an MRI scan to help researchers learn more about these conditions.
Bethesda, MarylandAges 2–100 - NCT00792155Recruiting
Register people with diagnosed ADPKD to build a kidney data resource
This trial builds a secure database by collecting information from adults who already have autosomal dominant polycystic kidney disease (ADPKD). Your information can help researchers understand the condition better and improve future care.
New York, New YorkAges 18 years+ - NCT00230620Recruiting
Study of inherited bleeding disorder genes in HHT families
This study looks at DNA (genetic material) in families affected by hereditary hemorrhagic telangiectasia (HHT). It aims to understand the genetic basis of HHT and why it runs in families.
LondonAges Any age - NCT00390104Recruiting
Study uses blood and skin samples to learn muscular disease causes
This study looks at samples from people with muscular dystrophy and from close relatives, to better understand neuromuscular diseases. You may be asked to provide a skin biopsy for research to help with genetic and molecular analysis.
Boston, MassachusettsAges 1 week–100 years
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.