Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07346976Recruiting
Jaundice management study using carbon monoxide breath test in newborns
This study uses a simple breath test to measure carbon monoxide levels in newborns, which may help doctors better manage jaundice. It aims to understand how these levels change and how they relate to jaundice treatment.
Yiwu, ZhejiangAges birth–4 weeks - NCT07347743Recruiting
Probiotic supplement for crying and colic in healthy newborns
This trial tests whether a daily probiotic supplement can reduce excessive crying and colic in healthy, full-term newborns. If your baby is healthy and born at UZ Brussel, this study may help find a gentle way to soothe colic.
Jette, Brussels CapitalAges 1 day–2 weeks - NCT07348601RecruitingPhase 2
Study of CSTI-500 for people with Prader-Willi syndrome
This trial tests an investigational drug called CSTI-500 for people with Prader-Willi syndrome who are in the hyperphagia (constant hunger) phase. It aims to see if the drug can improve behavior and reduce overeating. You and your caregiver will need to visit the clinic regularly and answer questions about symptoms.
Nashville, TennesseeAges 13–50 - NCT07349004Recruiting
Migraine with aura and PFO study
This study looks at the link between migraine with aura and a small hole in the heart called PFO. It may help researchers understand what causes migraines in some people.
Bologna, BOAges 18 years+ - NCT07352813Recruiting
Comparing numbing methods for kids with MIH teeth
This study tests two ways to numb teeth—in the bone or in the gum—to see which works better for children with weak enamel on their back teeth and front teeth. It may help find a pain-free way to treat these teeth.
AnkaraAges 6–12 - NCT07354646Recruiting
Understanding heart disease with T1 mapping MRI
This study uses a special type of MRI (T1 mapping) to better understand different heart conditions. It may help doctors improve diagnosis and treatment by looking at detailed images of your heart muscle.
Beijing, Beijing MunicipalityAges Any age - NCT07356050Recruiting
Measles vaccine study for children with sickle cell disease
This study checks if the measles vaccine works well in children with sickle cell disease. It aims to help protect children with this condition from measles.
Cincinnati, OhioAges 6 months–6 years - NCT07356401Recruiting
Cranial helmet treatment: parent expectations and satisfaction
This study looks at how well cranial helmets work for babies with flat head syndrome and how parents feel about the treatment and results.
Ankara, KeçiörenAges 3 months–1.5 years - NCT07356778RecruitingPhase 4
Study of sotatercept for Eisenmenger syndrome patients
This trial tests a new drug called sotatercept for people with Eisenmenger syndrome or a related heart defect that hasn't been repaired. It may help if current treatments aren't working well enough.
Fukuoka, Not Required For This CountryAges 18 years+ - NCT07357558Recruiting
Reproductive health experiences in adults with PCD
This study is a conversation-based research project to understand how reproductive issues affect adults with Primary Ciliary Dyskinesia (PCD), a rare lung condition. By sharing your experiences, you can help doctors and researchers better support patients like you.
SouthamptonAges 18 years+ - NCT07358013Recruiting
Endothelial cells in von Willebrand disease and related conditions
This study looks at special cells from blood vessels (endothelial colony-forming cells) in people with von Willebrand disease (a bleeding disorder) or a related acquired condition. The goal is to better understand these conditions using blood donations.
MilanAges 16 years+ - NCT07358156RecruitingPhase 1
Comparing a new dupilumab medicine to Dupixent in healthy adults
This trial tests a new version of Dupixent® (called CKD-706) to see how it compares to the approved medicine in healthy adults. It's a first step to make sure the new medicine works similarly and is safe.
Berlin, State of BerlinAges 18–55 - NCT07359690Recruiting
Study of Heart Muscle Biopsies
This study collects samples of heart muscle tissue (biopsy) to better understand heart conditions. It is for people who already need this biopsy for their healthcare.
Essen, North Rhine-WestphaliaAges 18 years+ - NCT07361536Recruiting
Heart health in MPS
This study looks at heart structure and function in people with mucopolysaccharidosis (MPS), a rare genetic disorder. It aims to understand how MPS affects the heart over time.
Orange, CaliforniaAges birth–99 years - NCT07362875Recruiting
Muscle imaging study for myotonic dystrophy
This study uses MRI scans to measure muscle changes in people with myotonic dystrophy (DM1 or DM2) and healthy volunteers. The goal is to find better ways to track the disease over time.
Winston-Salem, North CarolinaAges 18–65 - NCT07363304Recruiting
How ETI therapy affects body and gut in cystic fibrosis
This study looks at how the triple combination therapy (elexacaftor/tezacaftor/ivacaftor, or ETI) affects your body's metabolism, epigenetics, and gut bacteria in people with cystic fibrosis. It aims to understand the broader health benefits of this treatment.
Bari, BariAges 2 years+ - NCT07365254Recruiting
Newborn whole genome sequencing for genetic disease risk
This study looks at using whole genome sequencing in newborns and families with ongoing pregnancies, including those conceived naturally or with fertility treatments. It aims to better understand and manage genetic disease risks early.
Hangzhou, ZhejiangAges Any age - NCT07366086RecruitingPhase 3
Long-term safety of romosozumab for osteogenesis imperfecta in children
This study follows children who previously received romosozumab in an earlier trial to check their long-term safety. It helps understand if the treatment's benefits last safely over time.
Indianapolis, IndianaAges 5–19 - NCT07366593Recruiting
Immune & respiratory health in Down syndrome kids with pneumonia
This study looks at how the immune system and breathing are affected in children with Down syndrome who have pneumonia. It aims to find patterns that could lead to better treatments.
CairoAges 1–6 - NCT07367971RecruitingPhase 1
ABP-671 interaction study for gout patients
This study tests how a new drug, ABP-671, interacts with allopurinol (a common gout medicine) in people with gout. It is looking for participants with normal or moderately reduced kidney function.
Cary, North CarolinaAges 18–75 - NCT07369505RecruitingPhase 1
A study of Sapu003 for advanced tumors sensitive to mTOR
This trial tests a new drug, Sapu003, in people with certain advanced cancers that may respond to mTOR-targeted therapy. It is looking at two groups: postmenopausal women with a type of breast cancer (HR+/HER2-), and adults with kidney, liver, neuroendocrine, or TSC-related tumors. The goal is to see if Sapu003 is safe and effective.
AdelaideAges 18 years+ - NCT07370792Recruiting
Genetic mapping for multiple birth defects or intellectual disability
This study uses a new genetic technique to find hidden causes in people with multiple birth defects or intellectual disability who had standard genetic tests come back normal. It might help identify a genetic reason when other tests did not.
Clermont-FerrandAges Any age - NCT07371663RecruitingPhase 1/Phase 2
TCC1727 combination therapy for advanced solid tumors
This trial tests a new drug, TCC1727, combined with other treatments for people with advanced solid tumors that have stopped responding to standard therapy. It aims to see if these combinations can help shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07371767RecruitingEarly Phase 1
Gene editing for high triglycerides in kids with FCS
This trial tests a new gene-editing treatment (CS-121) for children and teens with a rare inherited condition called Familial Chylomicronemia Syndrome (FCS). It aims to lower very high triglyceride levels and reduce the risk of pancreatitis.
Shanghai, Shanghai MunicipalityAges 4–18
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.