Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease84
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California325
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York85
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07470320Recruiting
Placenta study in healthy and complicated pregnancies
This study looks at how the placenta works in healthy pregnancies and in pregnancies with conditions like pre-eclampsia, gestational diabetes, or fetal growth restriction. It may help find new ways to detect or treat these problems.
OxfordAges 18 years+ - NCT07468019Recruiting
New denture for upper jaw with some teeth
This trial tests a new denture design for people who still have some teeth in their upper jaw. It aims to help you eat and speak better.
CairoAges 10–35 - NCT07471516RecruitingPhase 1/Phase 2
Zoledronic acid for congenital dyserythropoietic anemia
This trial tests if a bone-strengthening drug called zoledronic acid can help people with congenital dyserythropoietic anemia (CDA), a rare type of anemia. It's for adults with moderate to severe anemia who may also need blood transfusions.
TianjinAges 18 years+ - NCT07471555Enrolling by invitation
Vascular access and intraosseous study for nursing students
This trial tests a teaching method for inserting a special needle into bone (intraosseous access) and regular IV lines. It is only for 4th year nursing students.
Valencia, ValenciaAges 18 years+ - NCT07470723Recruiting
Early cholesterol check for newborns of parents with lipid disorder
This study tests whether checking a newborn's blood spot for a genetic condition that causes very high cholesterol can help detect it early. It may help families understand their baby's risk and start care sooner if needed.
Madison, WisconsinAges 18 years+ - NCT06793969Recruiting
New method to close PFO hole in heart
This trial is testing a new way to close a small hole in the heart (called a PFO) using a thin tube and a guidewire to make the procedure smoother. It's for people who have had a stroke or mini-stroke and whose PFO is thought to be the cause.
ShanghaiAges 18–65 - NCT06794190Recruiting
Understanding liver health in Turner syndrome
This study aims to understand why some women with Turner syndrome develop liver problems. Researchers will analyze factors that may contribute to liver changes, which could lead to better monitoring and care.
BolognaAges 18 years+ - NCT07455578RecruitingPhase 1
Study of S-4321 for people with autoimmune or immune diseases
This trial tests a new medicine, S-4321, for people with various autoimmune conditions like rheumatoid arthritis, psoriasis, eczema, or lupus. It aims to see if the drug is safe and can help control the overactive immune system.
Charlestown, New South WalesAges 18–75 - NCT02103361Recruiting
Pregnancy registry for Stelara or Tremfya exposure
This study is a pregnancy exposure registry. It collects information to better understand pregnancy outcomes after exposure to Stelara or Tremfya (medicines used for autoimmune diseases).
La Jolla, CaliforniaAges Any age - NCT05938478Recruiting
Pregnancy registry for outcomes after tralokinumab exposure
This study tracks pregnancy and baby outcomes in people who have been pregnant while taking tralokinumab, a medication for eczema. It compares those outcomes to other eczema treatment groups to help doctors understand potential risks or reassuring effects.
La Jolla, CaliforniaAges Any age - NCT07456904Recruiting
Transition to adult care for cancer risk patients
This study looks at how young adults with a genetic risk for cancer (cancer predisposition syndrome) transition from St. Jude children's care to adult healthcare. It aims to understand their health outcomes and help improve future care.
Memphis, TennesseeAges 18 years+ - NCT07459582Recruiting
Home lactate meter and glucose meter accuracy in GSD
This study tests how well a home lactate meter and a standard blood sugar meter work for people with certain types of Glycogen Storage Disease (GSD Ia, Ib, or XI). If you or your child has one of these types, joining could help improve home monitoring.
Hartford, ConnecticutAges Up to 60 years - NCT07461519Recruiting
Study on female puberty in classic galactosemia
This study looks at how classic galactosemia affects puberty and ovary function in girls and women born between 1980 and 2024. It may help us understand and improve care.
Bologna, ItalyAges Up to 45 years - NCT07461896Recruiting
Nerve function study in Charcot-Marie-Tooth and related neuropathies
This study looks at how nerves work and their structure in people with Charcot-Marie-Tooth disease, CIDP, or anti-MAG neuropathy. It may help doctors better understand these conditions.
MilanAges 18 years+ - NCT07454174Recruiting
Study of a dietary program for polycystic kidney disease
This study tests a special medical food (Ren-Nu) to see if it helps with metabolism and kidney health in people with ADPKD. You would follow a dietary program and attend online classes.
Cleveland, OhioAges 18 years+ - NCT06789783RecruitingPhase 2/Phase 3
Lithium treatment for Cornelia de Lange syndrome
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
Milan, MIAges 4 years+ - NCT06796972Recruiting
Emotional impact of fetal surgery for spina bifida
This study looks at how parents make decisions about fetal surgery for spina bifida (myelomeningocele) and how they feel afterward. It aims to understand the emotional and psychological effects to better support families.
Paris, ParisAges 18 years+ - NCT06796920Recruiting
Spinal cord stimulation for leg problems in adrenomyeloneuropathy
This trial tests a small device placed near your spinal cord (called epidural spinal cord stimulation) to see if it can help improve leg movement and stiffness in people with adrenomyeloneuropathy (AMN). If you have AMN and trouble walking due to leg stiffness, this study may explore a new option for you.
Beijing, Beijing MunicipalityAges 22–50 - NCT06132048Recruiting
Testing a smartphone app for cystic fibrosis
This study tests a smartphone app called MuCopilot that helps you track your cystic fibrosis symptoms at home. Researchers want to see if the app is easy to use and can give accurate information about your condition.
RouenAges 18 years+ - NCT04452721Recruiting
Predicting outcomes for a chest brace in pectus carinatum
This study looks at what factors help predict how well a dynamic compression brace works for people with pectus carinatum (a chest wall that sticks out). It uses past patients’ records and later patients to see which early details relate to better or worse results.
Saint-EtienneAges 6–40 - NCT06048380RecruitingPhase 3
Ripasudil drops for FED patients having cataract surgery
This trial tests if ripasudil eye drops can help people with Fuchs' endothelial dystrophy (FED) during and after cataract surgery. It aims to see if the drops protect the eye's inner layer and improve recovery.
Singapore, SingaporeAges 50–100 - NCT06156670Recruiting
A study of closing a PFO to prevent strokes
This trial looks at the safety and results of closing a PFO (a small hole in the heart) in people who have had a stroke or embolism with no other clear cause. If you qualify, doctors will close your PFO using a small tube inserted through a blood vessel and then follow your health over time.
MoscowAges 18–70 - NCT06626672Recruiting
Digital Health Program for Kids with Heart Defects
This study uses digital tools to promote healthy habits in children (ages 8–14) with congenital heart disease. It aims to support both the child and their family in staying active and well.
MünchenAges 8–14 - NCT06799273Recruiting
Exercise capacity and outlook in cardiac amyloidosis
This study looks at how well people with cardiac amyloidosis can exercise and how that might relate to their long-term health. You'll do a supervised bike or treadmill test while your heart and lungs are monitored.
Milan, ItalyAges 18–100
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,456 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.