Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease84
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California325
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York85
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07477197Recruiting
Heart Institute Biobank for Adult Congenital Heart Disease
This study collects blood and tissue samples and health information from adults with or at risk for congenital heart disease or related heart conditions. It aims to help researchers better understand these conditions and improve future treatments.
Cincinnati, OhioAges 16 years+ - NCT07480265Recruiting
Homocysteine and early heart function in new high blood pressure
This study looks at a substance in your blood called homocysteine and how it affects the early filling of your heart's main pumping chamber. It may help doctors understand heart risks in people newly diagnosed with high blood pressure.
Konya, MeramAges 18 years+ - NCT07473739Recruiting
AI ultrasound for predicting pregnancy outcomes in early FGR
This study uses artificial intelligence (AI) to analyze ultrasound images and predict pregnancy outcomes for babies with early-onset fetal growth restriction (FGR) caused by placenta problems. If you are carrying a single baby with this condition and your doctor is continuing to monitor the pregnancy without immediate delivery, this trial may apply to you.
ShanghaiAges 20–43 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07478224Recruiting
Blood flow restriction training for osteogenesis imperfecta type I
This study tests whether a special type of strength training, called blood flow restriction training, can improve muscle, bone, and quality of life in adults with osteogenesis imperfecta type I.
GhentAges 18–65 - NCT07477873Enrolling by invitation
Emotions and jaw surgery recovery study
This study looks at how patients feel emotionally and physically before and after jaw surgery. It uses special software and questionnaires to track emotions, and checks the jaw joint and muscles after surgery. The goal is to see how these relate to recovery in patients having planned jaw surgery.
Kaunas, KaunoAges 18 years+ - NCT06626308Recruiting
Early signs in Huntington’s gene carriers study
This study looks for early changes in the body and brain of people who carry the Huntington’s disease gene but don’t yet have symptoms. It may help find better ways to track the disease early.
GrenobleAges 18–70 - NCT06769191RecruitingEarly Phase 1
CD7 car-t, stem cell transplant, and kidney transplant for SIOD
This trial tests a sequence of treatments for SIOD (a genetic condition causing immune and kidney problems). First, you receive CD7 car-t cells, then a stem cell transplant from a family donor, followed by a kidney transplant from the same donor. The goal is to see if this approach is safe and can help your body accept the new kidney.
Hangzhou, ZhejiangAges Any age - NCT06784440Recruiting
Finding noninvasive markers of graft injury after heart transplant
This study looks for noninvasive markers (like blood or urine tests) that can show if a heart transplant is being injured. It aims to make monitoring safer and easier for children and adults with congenital heart disease who have had a transplant.
BolognaAges Up to 44 years - NCT06785532Recruiting
Brain stimulation for hard-to-treat Tourette's syndrome
This trial tests a brain stimulation device (RNS) for people with Tourette's syndrome whose symptoms haven't improved with standard treatments. It aims to see if this approach can reduce tics and improve quality of life.
BeijingAges 18–65 - NCT07465263RecruitingPhase 3
Study of SYH2053 Injection for High Cholesterol in HeFH
This study tests a new injection called SYH2053 for people with HeFH, a genetic condition that causes very high cholesterol. It looks at whether the injection can safely lower LDL cholesterol when added to standard statin therapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07465718RecruitingPhase 3
Once-daily trientine for first-line Wilson's disease treatment
This trial tests a once-daily trientine pill as the first treatment for Wilson's disease, a condition where copper builds up in the body. It may help if you've never been treated for Wilson's disease or have only had zinc therapy briefly.
Denver, ColoradoAges 8 years+ - NCT07466745Recruiting
New Pulmonary Valve Study for Kids Needing Replacement
This study tests a new type of replacement valve for children who need a new pulmonary valve (the valve between the heart and lungs). Researchers want to see if the valve works safely and well in real-world use.
Los Angeles, CaliforniaAges 1.5 years–16 years - NCT07467564Recruiting
Does Dupilumab help anxiety and depression in eczema?
This study looks at whether Dupilumab (a treatment for moderate-to-severe eczema) can also help improve symptoms of anxiety and depression. It is for people with eczema who also have these mood symptoms and are about to start Dupilumab.
DohaAges 12 years+ - NCT06645899Recruiting
Italian database for parathyroid conditions
This study is creating a database of people with hypoparathyroidism or pseudohypoparathyroidism in Italy. It may help researchers learn more about these conditions and improve future care.
AlessandriaAges Any age - NCT06788470RecruitingPhase 1/Phase 2
Stem cell therapy for severe lung disease in premature babies
This trial tests whether umbilical cord stem cells can help premature babies with severe bronchopulmonary dysplasia (a chronic lung disease) who still need a breathing tube after standard hormone treatment. The goal is to see if it is safe and improves their lung condition.
Hangzhou, ZhejiangAges 8 months+ - NCT03327428Recruiting
Registry study for people with sickle cell disease
This study is a registry that collects information about people living with sickle cell disease. It may help researchers better understand sickle cell types in Germany, Austria, and Switzerland and support future research and care.
Heidelberg, Baden-WurttembergAges birth–100 years - NCT06524635RecruitingPhase 2
Study of lutikizumab for hidradenitis suppurativa or eczema
This study tests an investigational medicine called lutikizumab, given as shots under the skin, for people with moderate-to-severe hidradenitis suppurativa (HS) or atopic dermatitis (eczema). It looks at how the medicine affects skin changes and may help if other treatments haven’t worked.
Sacramento, CaliforniaAges 18–75 - NCT07469657Recruiting
Cost-effectiveness of a non-invasive prenatal test for genetic disorders
This study is testing a non-invasive prenatal blood test (NIPD) that can check for certain serious genetic disorders in your baby, instead of using more invasive methods like amniocentesis. If you are at risk of passing on a severe genetic condition, this test may help you get answers safely.
Paris, Île-de-France RegionAges 18 years+ - NCT07470723Recruiting
Early cholesterol check for newborns of parents with lipid disorder
This study tests whether checking a newborn's blood spot for a genetic condition that causes very high cholesterol can help detect it early. It may help families understand their baby's risk and start care sooner if needed.
Madison, WisconsinAges 18 years+ - NCT07471516RecruitingPhase 1/Phase 2
Zoledronic acid for congenital dyserythropoietic anemia
This trial tests if a bone-strengthening drug called zoledronic acid can help people with congenital dyserythropoietic anemia (CDA), a rare type of anemia. It's for adults with moderate to severe anemia who may also need blood transfusions.
TianjinAges 18 years+ - NCT07468513RecruitingPhase 4
Primaquine for vivax malaria in G6PD-intermediate or deficient adults
This trial tests how well the drug primaquine works for people with vivax malaria who have intermediate or low levels of an enzyme called G6PD. It aims to find safe and effective treatment options for this group.
ManausAges 18 years+ - NCT07464093Recruiting
Pilates for joint hypermobility pain
This trial tests if a special Pilates program can reduce pain in people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. You must have had pain for at least 3 months and be able to get on and off the floor on your own.
Chestnut Hill, MassachusettsAges 18 years+ - NCT07470320Recruiting
Placenta study in healthy and complicated pregnancies
This study looks at how the placenta works in healthy pregnancies and in pregnancies with conditions like pre-eclampsia, gestational diabetes, or fetal growth restriction. It may help find new ways to detect or treat these problems.
OxfordAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,456 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.